Jab1 antibody, Jab1 [6C3.38] Antibody, Mouse Monoclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Jab1 [6C3.38] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193297

Buy Jab1 antibody -

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Related Product Names:

- Jab1 antibody; Jab1; Jab 1, Jab-1; Jab1 [6C3.38]
- Mouse monoclonal antibody to human Jab1; Jab 1 Jab-1 Jab1 JabI; Jab 1 Jab-1 Jab1 JabI

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Jab1	Gene Name Synonym: Jab 1, Jab-1
Gi #: N/A	NCBI Acc #: NP_006828.2	Swiss Prot Acc #: Q92905
Length (aa): N/A	Mol. Weight (Da): 37579	Chrom Location: N/A

Clone: 6C3.38

Isotype: IgG2a

Light chain: kappa

Immunogen: The full-length mouse JAB-1 gene expressed in E. coli.

Antigen Species: Mouse

Positive Control: 293 cell lysate

Target: Jab1

Localization: Nuclear/Cytoplasmic

Concentration: 1 mg/ml

Purification Note: From hybridoma tissue culture supernatant

Storage Buffer: Phosphate-buffered saline, pH 7.4, containing no preservatives

Application Note: For IP: Use at a concentration of 0.5 - 1 ug/ml. For WB: Use at a concentration of 0.5-1 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Target protein molecular weight: 38

Cellular Localization: Nuclear/Cytoplasmic

Expression system: pGEX

Myeloma: NS1

Source/Host: Mouse

Purity/Purification: Protein G Affinity Purified

Clonality: Monoclonal

Crossreactivity: Human and Mouse - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for JAB1 ANTIBODY:

IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

JAB1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Jab1 antibody: Jab1; Jab 1, Jab-1; Mouse monoclonal antibody to human Jab1; Jab 1 Jab-1 Jab1 JabI; Jab 1 Jab-1 Jab1 JabI

JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts direclty with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.

Cofactor: Divalent metal ions (By similarity).

Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5.

Subcellular Location: Cytoplasm. Nucleus.

Domain: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It may constitute the catalytic center of the complex (By similarity).

Similarity: Belongs to the peptidase M67A family. CSN5 subfamily [view classification].

Similarity: Contains 1 MPN (JAB/Mov34) domain.

Jab1 [6C3.38] reacts with human and mouse - not yet tested in other species .

OMIM: 604850; gene. [NCBI / EBI]

Products similar to Jab1 antibody:

IgG

COPS5 (COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)), IgG

JAB1, IgG

Jab1 [6C3.38], IgG

CSN5, IgG

Jab1 [8H8.5], IgG

PRODUCT INTERACTIONS:

Jab1 [6C3.38] interacts with p27/kip1, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with p27 KIP1 [DCS-72.F6], IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with p27Kip1 (Phospho-Thr187), IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with p27Kip1 (Ab-10) Antibody, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with p27Kip1 (Phospho-Thr187) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with TRX E.Coli, Protein (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with TRX Yeast, Protein (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with Human Thioredoxin (r-ADF (human)), Protein (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with TRX Human, Protein (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with THIOREDOXIN, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PROTEIN GENE PRODUCT 9.5, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP 9.5, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with Goat anti UCH-L1 N-terminal, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5 GST Human, Protein (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5 Human, Protein (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5, Protein (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PROTEIN GENE PRODUCT 9.5, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP 9.5 [13C4], IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5 [10A1] *B1G1, IgG (GenWay Catalog #: 20-272-193297).

Jab1 [6C3.38] interacts with PGP9.5 (ready-to-use), IgG (GenWay Catalog #: 20-272-193297).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Jab1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Jab1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Jab1 antibody, all related information, articles, resources about Jab1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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