SMRT antibody, SMRT [1542] Antibody, Mouse Monoclonal Antibody

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SMRT [1542] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193334

Buy SMRT antibody -

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Related Product Names:

- SMRT antibody; SMRT; Silencing Mediator for Retinoid and Thyroid receptor; SMRT [1542]
- Mouse monoclonal antibody to human SMRT; 9612; NCOR2; 600848; Q9Y618; CTG26; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC-1; TRAC1;; 9612; NCOR2; 600848; Q9Y618; CTG26; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC-1; TRAC1;

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: SMRT	Gene Name Synonym: Silencing Mediator for Retinoid and Thyroid receptor
Gi #: N/A	NCBI Acc #: NP_001070729.1	Swiss Prot Acc #: Q9Y618
Length (aa): N/A	Mol. Weight (Da): 274034	Chrom Location: N/A

Clone: 1542

Isotype: IgG1

Light chain: kappa

Immunogen: A synthetic peptide from the human SMRT protein corresponding to amino acids 994-1005 (ASASDPHREKTQ) coupled to KLH.

Antigen Species: Human

Positive Control: HBL100

Target: SMRT

Concentration: 1 mg/ml

Purification Note: From hybridoma tissue culture supernatant

Storage Buffer: Phosphate-buffered saline, pH 7.4, containing no preservatives

Application Note: For IP: Use at an assay dependant concentration. For WB: Use at an assay dependant dilution. Predicted molecular weight: 274 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Target protein molecular weight: 168

Myeloma: Fox NY

Source/Host: Mouse

Purity/Purification: Protein G Affinity Purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for SMRT ANTIBODY:

IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

SMRT ANTIBODY TARGET DESCRIPTION:

Synonym Names for SMRT antibody: SMRT; Silencing Mediator for Retinoid and Thyroid receptor; Mouse monoclonal antibody to human SMRT; 9612; NCOR2; 600848; Q9Y618; CTG26; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC-1; TRAC1;; 9612; NCOR2; 600848; Q9Y618; CTG26; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC-1; TRAC1;

SMRT-1542 recognizes the Silencing Mediator for Retinoid and Thyroid receptors (SMRT) gene product, a 168 kDa nuclear protein. Nuclear hormone receptors are transcription factors regulated by ligand binding. In the absence of ligand there is a physical interaction between the nuclear receptors that do not interact with Hsp90 and a family of corepressors which includes SMRT. SMRT helps target histone deacetylases and other components of a multiprotein repressor complex to the specific target promoter to silence gene transcription

Function: Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.

Subunit: Interacts with HDAC7 (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. The SRMT isoform interacts with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3. Interacts with C1D (By similarity). Interacts with ATXN1L.

Subcellular Location: Nucleus.

Tissue Specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Induction: Regulated during cell cycle progression.

Domain: The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).

Domain: The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

Similarity: Belongs to the N-CoR nuclear receptor corepressors family.

Similarity: Contains 2 SANT domains.

SMRT [1542] reacts with human - not yet tested in other species .

OMIM: 600848; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Notch signaling pathway 04330

Products similar to SMRT antibody:

IgG

NCOR2 (nuclear receptor co-repressor 2), IgG

SMRT [1212], IgG

NCOR2 (nuclear receptor co-repressor 2), IgG

SMRT, IgG

SMRT [1542], IgG

PRODUCT INTERACTIONS:

SMRT [1542] interacts with AHR, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with AHR (aryl hydrocarbon receptor), IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with HDAC1 (histone deacetylase 1), IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with HDAC1 [HDAC1-21], IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Anti-HDAC-1, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with HDAC1, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with HDAC1 (ready-to-use), IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with HDAC1, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with HDAC 10, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor [4D8], IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor [SPM211] (ready-to-use), IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor [4D8], IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor [PR-AT 4.14], IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone Receptor (Phospho-Ser190), IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone Receptor (Phospho- Ser190) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone Receptor, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with PGR Human, Protein (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor phospho S190, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor phospho S294, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with PROGESTERONE RECEPTOR, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor [1A6], IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with PgR [4D8], IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor [PGR-1A6] antibody, IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor (ready-to-use), IgG (GenWay Catalog #: 20-272-193334).

SMRT [1542] interacts with Progesterone receptor [hpra 2 + hpra 3], IgG (GenWay Catalog #: 20-272-193334).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: SMRT antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of SMRT antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SMRT antibody, all related information, articles, resources about SMRT antibody are being stored on our online database. Let us know if you have questions regarding this product.

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