Rad51 antibody, Rad51 [13E4] Antibody, Mouse Monoclonal Antibody

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Rad51 [13E4] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193366

Buy Rad51 antibody -

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Related Product Names:

- Rad51 antibody; Rad51; Rad 51, hRad51, RecA, hRecA HsRad51 HsT16930 RAD51A E coli RecA homolog RecA-like recombination protein A; Rad51 [13E4]
- Mouse monoclonal antibody to human Rad51; 5888; RAD51; 114480; Q06609; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA;; 5888; RAD51; 114480; Q06609; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA;

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Rad51	Gene Name Synonym: Rad 51, hRad51, RecA, hRecA HsRad51 HsT16930 RAD51A E coli RecA homolog RecA-like recombination protein A
Gi #: N/A	NCBI Acc #: NP_002866.2	Swiss Prot Acc #: Q06609
Length (aa): N/A	Mol. Weight (Da): 36966	Chrom Location: N/A

Clone: 13E4

Isotype: IgG1

Light chain: kappa

Immunogen: Recombinant human Rad51 protein.

Antigen Species: Human

Positive Control: HeLa whole cell extract, recombinant human Rad51 protein

Target: Rad51

Concentration: 1 mg/ml

Purification Note: From mouse ascitic fluid.

Storage Buffer: Phosphate-buffered saline, pH 7.2, containing no preservatives

Application Note: For WB: Use at a dilution of 1:500 - 1:1,000. Predicted molecular weight: 37 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Target protein molecular weight: 37

Myeloma: NS1

Source/Host: Mouse

Purity/Purification: Protein G affinity purified.

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for RAD51 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

RAD51 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Rad51 antibody: Rad51; Rad 51, hRad51, RecA, hRecA HsRad51 HsT16930 RAD51A E coli RecA homolog RecA-like recombination protein A; Mouse monoclonal antibody to human Rad51; 5888; RAD51; 114480; Q06609; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA;; 5888; RAD51; 114480; Q06609; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA;

Rad51, a 37 kDa protein, is the human homologue of E. coli RecA protein and a member of the RAD52 epistasis group in S. cerevisiae. In recent studies it has been reported that BRCA1 interacts with Rad51 and disease-causing mutations have been found in the BRCA1 region necessary for BRCA1/Rad51 interaction, implying that this interaction is important for tumor suppression. BRCA2 and Rad51 have also been shown to interact by direct binding of the BRC repeats located within exon 11 of BRCA2. When these repeats are deleted, the interaction is lost and cells become hypersensitive to the DNA damage caused by methyl methanesulfonate (MMS).

Function: May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments.

Subunit: Interacts with BRCA1, BRCA2 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Part of a complex with RAD51C and RAD51B. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1/CHK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer (By similarity). Interacts with OBFC2B.

Subcellular Location: Nucleus. Note=Colocalizes with RAD51AP1 to multiple nuclear foci upon induction of DNA damage.

Tissue Specificity: Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.

Ptm: Phosphorylated. Phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination.

Disease: Defects in RAD51 are associated with breast cancer (BC) [MIM:114480].

Similarity: Belongs to the recA family. RAD51 subfamily.

Similarity: Contains 1 HhH domain.

Rad51 [13E4] reacts with human - not yet tested in other species .

OMIM: 114480; phenotype. [NCBI / EBI]
179617; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Pancreatic cancer 05212
Reactome Event:DNA Repair 73894

Products similar to Rad51 antibody:

IgG

RAD51D / RAD51L3, IgG

RAD51C, IgG

Rad51 [14B4], IgG

Rad51B [Rad51B 1H3/13], IgG

PIR51 / RAD51AP1, IgG

PRODUCT INTERACTIONS:

Rad51 [13E4] interacts with BRCA2, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with BRCA2 [5F6], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with BRCA2 [3E6], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with BRCA2 [9D3], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with Cellular tumor antigen p53, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 Human, Protein (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53M Human, Protein (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [SP5], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 phospho S15, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [DO-13], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [DO-7], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [Pab240], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [D01], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [3F301], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [DO-7] (ready-to-use), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [BP53-12], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with I-kappaB-alpha (Phospho-Ser32/Ser36), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Phospho-Ser15), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Phospho-Ser46), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Phospho-Ser315), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Ab-15), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Ab-46), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Ab-315), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Phospho-Ser15) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Phospho-Ser46) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (Phospho-Ser315) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with TP53 (tumor protein p53 (Li-Fraumeni syndrome)), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (a.a. 32-79), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (a.a. 88-109), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 (a.a. 306-393), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with Mouse p53, Wild Type, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with Human p53 Oncogene, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [B20.1 (BP 53.122)] antibody (ready-to-use), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 AIP1, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [BP53-12] (FITC), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [DO-2], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [DO-1], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with P53, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [B20.1 (BP 53.122)] antibody (FITC), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53, IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with P53 [SP5] (ready-to-use), IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [DO-1], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [B449], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [Pab240], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [Pab1801], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [D01], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53 [DO-2], IgG (GenWay Catalog #: 20-272-193366).

Rad51 [13E4] interacts with p53, IgG (GenWay Catalog #: 20-272-193366).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

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Precautions: Rad51 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Rad51 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Rad51 antibody, all related information, articles, resources about Rad51 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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