CXCR4 antibody, CXCR4 [12G5] Antibody, Mouse Monoclonal Antibody

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CXCR4 [12G5] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193480

Buy CXCR4 antibody -

Volume:

Related Product Names:

- CXCR4 antibody; CXCR4; 7852; CXCR4; 162643; P61073; CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;; CXCR4 [12G5]
- Mouse Monoclonal to CXCR4 / Fusin / LESTR / HUMSTR ; 7852; CXCR4; 162643; P61073; CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;; C-X-C chemokine receptor type 4

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CXCR4	Gene Name Synonym: 7852; CXCR4; 162643; P61073; CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
Gi #: N/A	NCBI Acc #: NP_001008540.1	Swiss Prot Acc #: P61073
Length (aa): N/A	Mol. Weight (Da): 39746	Chrom Location: N/A

Clone: 12G5

Isotype: IgG2a

Positive Control: HeLa Cells

Target: CXCR4

Localization: Cell Membrane

Concentration: 0.2 mg/ml

Storage Buffer: 10mM Phosphate-buffered saline, pH 7.4, containing 0.2% BSA and 0.1% sodium azide

Application Note: Blocks CD4-dependent infection by certain Ttropic strains of HIV-1. Blocks CD4-independent infection by HIV-2. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Cellular Localization: Cell Membrane

Source/Host: Mouse

Purity/Purification: Protein A affinity purified

Clonality: Monoclonal

Crossreactivity: Human, Baboon, Rhesus, and Cynomolgus Monkeys - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CXCR4 ANTIBODY:

FACS: Tested

TESTING: (secondary reagents and protocols )

Not Available

CXCR4 ANTIBODY TARGET DESCRIPTION:

Synonym Names for CXCR4 antibody: CXCR4; 7852; CXCR4; 162643; P61073; CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;; Mouse Monoclonal to CXCR4 / Fusin / LESTR / HUMSTR ; 7852; CXCR4; 162643; P61073; CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;; C-X-C chemokine receptor type 4

CXCR4, also termed Fusin, LESTR, or HUMSTR is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. It is expressed predominantly on naïve T-cells, subsets of peripheral blood, neutrophils, monocytes, and various cell lines.

Function: Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Subunit: Monomer. Can form dimers. Interacts with HIV-1 surface protein gp120 and Tat.

Subcellular Location: Cell membrane; Multi-pass membrane protein.

Tissue Specificity: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Domain: The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.

Ptm: Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.

Ptm: O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.

Disease: Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts, hypogammaglobulinemia, infections, and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.

Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].

CXCR4 [12G5] reacts with human, baboon, rhesus, and cynomolgus monkeys - not yet tested in other species.

OMIM: 162643; gene. [NCBI / EBI]
193670; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Axon guidance 04360
KEGG pathway: Cytokine-cytokine receptor interaction 04060
KEGG pathway: Leukocyte transendothelial migration 04670
Reactome Event:HIV Infection 162906

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Protein

NEUROPEPTIDE Y RECEPTOR 1, Protein

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Precautions: CXCR4 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CXCR4 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CXCR4 antibody, all related information, articles, resources about CXCR4 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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