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| Blood Group antigen B [3E7] antibody (ready-to-use) Antibody, Mouse Monoclonal Antibody |
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| Catalog Number: 20-272-193564 |
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| Related Product Names:
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Blood Group antigen B antibody; Blood Group antigen B; Blood Group antigen B [3E7] antibody (ready-to-use)
- Mouse Monoclonal [3E7] to Blood Group B Antigen; NAGAT; Histo-blood group ABO system transferase |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: Blood Group antigen B |
Gene Name Synonym: N/A |
Gi #:
N/A |
NCBI Acc #:
NP_065202.2 |
Swiss Prot Acc #:
P16442 |
Length (aa): N/A |
Mol. Weight (Da): 40934 |
Chrom Location: N/A |
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 Source/Host: Mouse
Clonality: Monoclonal
Format: Prediluted
Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for BLOOD GROUP ANTIGEN B ANTIBODY: |
| IHC-Fr, IHC-P: Tested |
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| BLOOD GROUP ANTIGEN B ANTIBODY TARGET DESCRIPTION: |
Synonym Names for Blood Group antigen B antibody: Blood Group antigen B; Mouse Monoclonal [3E7] to Blood Group B Antigen; NAGAT; Histo-blood group ABO system transferase
Monoclonal Mouse Anti-Human Blood Group B
Function: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal) whereas O individuals lack such activity.
Catalytic Activity: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactose.
Catalytic Activity: UDP-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.
Cofactor: Binds 1 manganese ion per subunit.
Pathway: Protein modification; protein glycosylation.
Subcellular Location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Domain: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
Ptm: The soluble form derives from the membrane form by proteolytic processing.
Polymorphism: The sequence shown is that of the A transferase. The B form differs by a few residues substitutions. The O phenotype results from a single base frameshift in the N-terminal extremity of the gene, resulting in a severly truncated protein without catalytic activity.
Similarity: Belongs to the glycosyltransferase 6 family.
OMIM: 110300; gene+phenotype. [NCBI / EBI]
Pathways:
KEGG pathway: Glycan structures - biosynthesis 2 01031
KEGG pathway: Glycosphingolipid biosynthesis - lactoseries 00601
KEGG pathway: Glycosphingolipid biosynthesis - neo-lactoseries 00602
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: Blood Group antigen B antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of Blood Group antigen B antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Blood Group antigen B antibody, all related information, articles, resources about Blood Group antigen B antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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