SRC3 antibody, SRC3 Antibody, Rabbit Polyclonal Antibody

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SRC3 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-272-195029

Buy SRC3 antibody -

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Related Product Names:

- SRC3 antibody; SRC3; 8202; NCOA3; 601937; Q9Y6Q9; ACTR; AIB1; CAGH16; CTG26; RAC3; SRC3; TNRC14; TNRC16; TRAM-1; pCIP;; SRC3
- Rabbit polyclonal to SRC3; 8202; NCOA3; 601937; Q9Y6Q9; ACTR; AIB1; CAGH16; CTG26; RAC3; SRC3; TNRC14; TNRC16; TRAM-1; pCIP;; Nuclear receptor coactivator 3

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: SRC3	Gene Name Synonym: 8202; NCOA3; 601937; Q9Y6Q9; ACTR; AIB1; CAGH16; CTG26; RAC3; SRC3; TNRC14; TNRC16; TRAM-1; pCIP;
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: Q9Y6Q9
Length (aa): N/A	Mol. Weight (Da): 155293	Chrom Location: N/A

Isotype: IgG

Immunogen: Immunogen was a synthetic peptide, which represented a portion of human nuclear receptor coactivator 3 encoded within exon 13 (LocusLink ID 8202).

Antigen Species: Human

Target: SRC3

Localization: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

Concentration: 1 mg/ml

Storage Buffer: Preservative: 0.1% Sodium Azide; Constituents: Tris-citrate/phosphate. pH 7-8

Application Note: IP: Use at a concentration of 20 µg/10mg extract. WB: Use at a dilution of 1/1000 - 1/10000. Detects a band of approximately 170 kDa (predicted molecular weight: 170 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

Source/Host: Rabbit

Purity/Purification: Immunogen affinity purified

Clonality: Polyclonal

Crossreactivity: Human - Not yet tested in other species

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for SRC3 ANTIBODY:

IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

SRC3 ANTIBODY TARGET DESCRIPTION:

Synonym Names for SRC3 antibody: SRC3; 8202; NCOA3; 601937; Q9Y6Q9; ACTR; AIB1; CAGH16; CTG26; RAC3; SRC3; TNRC14; TNRC16; TRAM-1; pCIP;; Rabbit polyclonal to SRC3; 8202; NCOA3; 601937; Q9Y6Q9; ACTR; AIB1; CAGH16; CTG26; RAC3; SRC3; TNRC14; TNRC16; TRAM-1; pCIP;; Nuclear receptor coactivator 3

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate.SRC3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Catalytic Activity: Acetyl-CoA + histone = CoA + acetylhistone.

Enzyme Regulation: Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors.

Subunit: Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol.

Subcellular Location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

Tissue Specificity: Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

Domain: Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).

Ptm: Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.

Ptm: Methylated by CARM1 (By similarity).

Ptm: Phosphorylated by IKK complex. Regulated its function.

Polymorphism: The length of the poly-Gln region is polymorphic in the normal population.

Miscellaneous: NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.

Similarity: Belongs to the SRC/p160 nuclear receptor coactivator family.

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain.

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain.

SRC3 reacts with human - not yet tested in other species.

OMIM: 601937; gene. [NCBI / EBI]

Products similar to SRC3 antibody:

IgG

ARP1 homolog B, IgG

NCOR2 (nuclear receptor co-repressor 2), IgG

Activin receptor type IIA, IgG

SRC3, IgG

AIB1 [AC3], IgG

PRODUCT INTERACTIONS:

SRC3 interacts with Inhibitor of nuclear factor kappa-B kinase alpha subunit, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK alpha [14A231], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK -alpha (Phospho-Thr23), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK -alpha (Ab-23), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK -alpha (Phospho-Thr23) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Rabbit A' IKK-alpha, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK-alpha Control Peptide, Peptide (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Anti-IKK alpha, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Anti-IKK alpha CONTROL PEPTIDE, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK alpha phospho S176, S180, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with p300 [3G230], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with p300, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B401 (AER303)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B402 (AER304)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B403 (AER308)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B404 (AER310)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B405 (AER311)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B406 (AER314)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B407 (AER315)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B408 (AER317)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B409 (AER320)], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [B30.1], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [6F11], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser104), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser106), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser118), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser167), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Ab-104), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Ab-106), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Ab-118), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Ab-167), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser104) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser106) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser118) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor-alpha (Phospho-Ser167) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Estrogen Receptor, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ERa Human, Protein (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ESTROGEN RECEPTOR ALPHA, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha (ready-to-use), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [6F11], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha [1F3], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with ER alpha, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Inhibitor of nuclear factor kappa B kinase subunit beta, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKKb, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK beta [10AG2], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK beta [10A9B6], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Rabbit A' IKK-beta, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK-beta Control Peptide, Peptide (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Anti-IKK beta, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with Anti-IKK beta CONTROL PEPTIDE, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with NF-kappa-B essential modulator, IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK gamma [46B844], IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells. kinase gamma), IgG (GenWay Catalog #: 18-272-195029).

SRC3 interacts with IKK gamma, IgG (GenWay Catalog #: 18-272-195029).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: SRC3 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of SRC3 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SRC3 antibody, all related information, articles, resources about SRC3 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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