Activin receptor type IIB antibody, Activin receptor type IIB Antibody, Goat Polyclonal Antibody

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Activin receptor type IIB Antibody, Goat Polyclonal Antibody

Catalog Number: 18-272-195153

Buy Activin receptor type IIB antibody -

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Related Product Names:

- Activin receptor type IIB antibody; Activin receptor type IIB; 93; ACVR2B; 602730; Q13705; ActR-IIB; MGC116908;; Activin receptor type IIB
- Goat polyclonal to Activin Receptor Type IIB; 93; ACVR2B; 602730; Q13705; ActR-IIB; MGC116908;; Activin receptor type-2B

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Activin receptor type IIB	Gene Name Synonym: 93; ACVR2B; 602730; Q13705; ActR-IIB; MGC116908;
Gi #: N/A	NCBI Acc #: NP_001097.2	Swiss Prot Acc #: Q13705
Length (aa): N/A	Mol. Weight (Da): 57724	Chrom Location: N/A

Isotype: IgG

Immunogen: Recombinant human activin receptor IIB extracellular domain

Antigen Species: Human

Specificity: Based on ELISA, this antibody exhibits approximately 15 % cross-reactivity with recombinant human activin receptor IA. In immunoblotting, this antibody shows no cross-reactivity with recombinant human activin receptor IIA.

Target: Activin receptor type IIB

Concentration: Lot specific

Purification Note: From polyclonal serum

Storage Buffer: Phosphate-buffered saline, pH 7.2, containing 5% trehaiose

Application Note: For ELISA: Use at a concentration of 0.5-1.0 ug/ml. For Neut: Used at a concentration of 1-3 ug/ml this antibody will block 50 % of the binding of 30 ng/ml recombinant human activin A to immobilized recombinant human activin receptor IIB/Fc chimera (100 ul of a 0.5 ug/ml solution coating each well) in an ELISA assay. For WB: Used at a concentration of 0.1 ug/ml to 0.2 ug/ml this antibody detects human activin receptor IIB at approximately 20 ng/lane under reducing and non-reducing conditions.. Predicted molecular weight: 58 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Plasma membrane

Source/Host: Goat

Purity/Purification: Affinity purified with antigen

Clonality: Polyclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ACTIVIN RECEPTOR TYPE IIB ANTIBODY:

ELISA, Neut, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

ACTIVIN RECEPTOR TYPE IIB ANTIBODY TARGET DESCRIPTION:

Synonym Names for Activin receptor type IIB antibody: Activin receptor type IIB; 93; ACVR2B; 602730; Q13705; ActR-IIB; MGC116908;; Goat polyclonal to Activin Receptor Type IIB; 93; ACVR2B; 602730; Q13705; ActR-IIB; MGC116908;; Activin receptor type-2B

Activin, a disulfide-linked homodimeric protein is secreted by Sertolicells in the testis and granulosa cells in the ovary. In early studies, this peptide was thought to be an inhibin and not recognized as a unique compound. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits have been cloned (mammalian beta A, beta B, beta C, beta E, and Xenopus beta D). The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (beta A-beta A), activin B (beta B-beta B), activin AB (beta B-beta A), inhibin A (alpha-beta A) abd inhibin B (alpha-beta B). Activins have a wide range of biological activities including mesoderm induction neural cell differentiation, bone remodeling, hematopoiesis, and reproductive physiology. Activins are also involved in growth and differentiation of several tissues from different species. This protein also plays a key role in the production and regulation of hormones such as FSH, LH, GnRH, and ACTH. Activin influences erythropoiesis and the potentiation of erythroid colony formation, oxytocin secretion, paracrine, and autocrine regulation. Similar to other TGF-beta family members, activins exert their biological activities through the effects of the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated type I and type II receptors. Activin type I and type II receptors are distinguished by the level of sequence homology of their kinase domains and other structural and functional features. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported. Type I activin receptors do not bind directly to activin but will associate with the type II receptor-activin complex and initiate signal transduction. Recombinant soluble activin type II receptors bind activin with high affinity and are potent activin antagonists. Activin type II receptors are highly conserved and will also bind inhibin, BMP2, and BMP7 with lower affinities. Human, mouse, and rat type II activin receptors share 98 % homology.

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic Activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor: Magnesium or manganese (By similarity).

Subcellular Location: Membrane; Single-pass type I membrane protein.

Disease: Defects in ACVR2B are a cause of left-right axis malformations [MIM:602730]. Th effect is due to the loss of normal left-right asymmetry. Complete left-right asymmetry reversal imparts no deleterious consequences to the affected individual whereas randomization typically results in complex, often lethal heart malformations as well as abdominal abnormalities.

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Similarity: Contains 1 protein kinase domain.

Activin receptor type IIB reacts with human - not yet tested in other species.

OMIM: 602730; gene+phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Cytokine-cytokine receptor interaction 04060
KEGG pathway: TGF-beta signaling pathway 04350
Reactome Event:Signaling by BMP 201451

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Precautions: Activin receptor type IIB antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Activin receptor type IIB antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

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