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| FGFR1 Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-272-195175 |
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| Related Product Names:
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FGFR1 antibody; FGFR1; 2260; FGFR1; 101600; P11362; BFGFR; C-FGR; CEK; FLG; FLT2; H2; H3; H4; H5; KAL2; N-SAM;; FGFR1
- Rabbit polyclonal to FGFR1; 2260; FGFR1; 101600; P11362; BFGFR; C-FGR; CEK; FLG; FLT2; H2; H3; H4; H5; KAL2; N-SAM;; Basic fibroblast growth factor receptor 1 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: FGFR1 |
Gene Name Synonym: 2260; FGFR1; 101600; P11362; BFGFR; C-FGR; CEK; FLG; FLT2; H2; H3; H4; H5; KAL2; N-SAM; |
Gi #:
N/A |
NCBI Acc #:
N/A |
Swiss Prot Acc #:
P11362 |
Length (aa): N/A |
Mol. Weight (Da): 91868 |
Chrom Location: N/A |
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 Isotype: IgG
Immunogen: Synthetic peptide: EALEERPAVMTSPLK conjugated to KLH, corresponding to amino acids 360-373 of Human FGFR1 with a C-terminally added lysine.
Antigen Species: Human
Specificity: No reaction with FGFR-2 and FGFR-3 is detected.
Target: FGFR1
Concentration: 1.5 mg/ml
Purification Note: The product is an affinity-purified antibody prepared from pooled sera.
Storage Buffer: Phosphate-buffered saline, pH 7.4, containing 15 mM sodium azide 1% and BSA
Application Note: For IHC-P (trypsin-digested): Use at a dilution of 1:200. For IP: Use at an assay dependent dilution. For WB: Use at a dilution of 1:400. The epitopes recognized by the antibody are resistant to routine formalin-fixation and paraffin embedding to other fixatives e.g. Methacam, Bouins solution, ethanol, and B5. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Target protein molecular weight: 110-120 kDa
Source/Host: Rabbit
Purity/Purification: Immunogen affinity purified
Clonality: Polyclonal
Crossreactivity: Human - Not yet tested in other species
Format: Liquid
Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for FGFR1 ANTIBODY: |
| IHC-P, IP, WB: Tested |
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| FGFR1 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for FGFR1 antibody: FGFR1; 2260; FGFR1; 101600; P11362; BFGFR; C-FGR; CEK; FLG; FLT2; H2; H3; H4; H5; KAL2; N-SAM;; Rabbit polyclonal to FGFR1; 2260; FGFR1; 101600; P11362; BFGFR; C-FGR; CEK; FLG; FLT2; H2; H3; H4; H5; KAL2; N-SAM;; Basic fibroblast growth factor receptor 1
Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides (17-38 kDa) that are potent physiological regulators of growth and differentiation of a wide variety of cells of mesodermal, ectodermal and endodermal origin. FGFs are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, in hematopoiesis as well as in tissue remodeling and maintenance. They also have been implicated in pathological conditions such as tumorigenesis and metastasis. To date, the FGF family consists of at least 23 members designated FGF1 through FGF23. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR1 [flg-1(fms-like gene 1)]; FGFR2 [bek (bacterial expressed kinase gene product)]; FGFR3 (cek-2), and FGFR4. Multiple additional variants (isoforms) arising by alternative splicing have been reported: soluble, secreted, or possibly cleaved forms of FGFR1 and FGFR2 have also been found in body fluids or were artificially constructed, [e.g. a soluble FGF-binding protein containing the extracellular region of FGFR1 and the secreted form of placental alkaline phosphatase (FRAP1)]. FGFRs are members of the tyrosine kinase family of growth factor receptors. They are glycosylated 110- 150 kDa proteins that are constructed of an extracellular ligand binding region with either two (alpha type) or typically three (alpha type) immunoglbulin (Ig)-like domains and an eight amino acid acidic box, a transmembrane region, and a cytoplasmic split tyrosine kinase domain that is activated following ligand binding and receptor dimerization. The ligand binding site of FGFRs is confined to the extracellular Ig-like domains 2 and 3.FGFRs exhibit overlapping recognition and redundant specificity. One receptor type may bind with a similar affinity several of the FGFs. Also one FGF type may bind similarly to several distinct receptors. This accounts for the rather identical effects of different FGF ligands on common cell types. FGFís binding to cellular FGFRs depend on or is markedly facilitated by the low-affinity interaction of FGF with the polysaccharide component of the cell surface or extracellular matrix heparan sulfate proteoglycans (HSPG). For example, perlecan, a basement membrane HSPG, promotes high affinity binding of FGF2 in vitro and angiogenesis in vivo. Signal transduction by FGFRs requires dimerization or oligomerization and autophosphorylation of the receptors through their tyrosine kinase domain. Subsequent association with cytoplasmic signaling molecules leads to DNA synthesis or differentiation. The signaling and biological responses elicited by distinct FGFRs substantially differ and are dictated by the intracellular domain. At the mRNA level, FGFR1 is highly expressed in developing human tissues including the brain (preferentially in neurons), vascular basement membranes, skin, and bone growth plates. It may be found in most anchorage dependent cells on their membrane and also may be localized around and in nuclei. Pfeiffer syndrome, as well as other disorders of human skeletal development, is the result of a mutation in the extracellular domain of FGFR1.
Function: Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF).
Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Interacts with SHB. Interacts with KLB (By similarity).
Subcellular Location: Membrane; Single-pass type I membrane protein.
Ptm: Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.
Disease: Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.
Disease: Defects in FGFR1 are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadism is a condition characterized by abnormally decreased gonadal function, with retardation of growth and sexual development. Hypogonadotropic hypogonadism is due to inadequate secretion of gonadotropins. It results from failure to release sufficient gonadotropin-releasing hormone.
Disease: Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous.
Disease: Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant.
Disease: Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome.
Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.
Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity: Contains 1 protein kinase domain.
FGFR1 reacts with human - not yet tested in other species .
OMIM: 101600; phenotype. [NCBI / EBI]
136350; gene. [NCBI / EBI]
146110; phenotype. [NCBI / EBI]
147950; phenotype. [NCBI / EBI]
166250; phenotype. [NCBI / EBI]
190440; phenotype. [NCBI / EBI]
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| PRODUCT INTERACTIONS: |
FGFR1 interacts with E-cadherin, Reagents (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with E Cadherin [67A4], IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with pan Cadherin [CH-19], IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Human E-cadherin EIA Kit, ELISA_Kits (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with E-Cadherin, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Cadherin-E Human, Protein (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with E Cadherin [DECMA-1], IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with pan Cadherin [CH-19] (FITC), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with pan Cadherin (ready-to-use), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with pan Cadherin, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with E Cadherin (ready-to-use), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with E Cadherin, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with CD324, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with E-Cadherin, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with E-Cadherin Phospho (pS838/840), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with CTNNB1, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with CATENIN, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with b-Catenin (CTNNB1) Dephospho, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with b-Catenin (CTNNB1), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with BETA-CATENIN, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta Catenin [6F9], IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta Catenin [15B8], IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta-Catenin (Phospho-Thr41/Ser45), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with b-Catenin (Ab-41/45), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta-Catenin (Phospho-Ser33), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta-Catenin (Phospho-Ser37), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin (Ab-33), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin (Ab-37), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta-Catenin (Phospho-Thr41/Ser45) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta-Catenin (Phospho-Ser33) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta-Catenin (Phospho-Ser37) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin beta, C-terminal (exon 14), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin beta, N-terminal (exon 2), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin, beta, Core, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin beta, C-terminal (a.a. 769-781), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin, beta, dephosphorylated (35-50), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin beta, pTyr 86, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin beta, pTyr 654, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Catenin beta,(exon 3), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta Catenin phospho S33, S37 [BC-22], IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta Catenin [15B8] (Cy3), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta Catenin (ready-to-use), IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta Catenin, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta Catenin phospho S33 [BC-76], IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with beta-catenin, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Beta-Catenin, IgG (GenWay Catalog #: 18-272-195175).
FGFR1 interacts with Beta-Catenin Phospho (pT41/pT45), IgG (GenWay Catalog #: 18-272-195175).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: FGFR1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of FGFR1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FGFR1 antibody, all related information, articles, resources about FGFR1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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