APE antibody, APE Antibody, Rabbit Polyclonal Antibody

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APE Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-272-196003

Buy APE antibody -

Size:

Related Product Names:

- APE antibody; APE; 328; APEX1; 107748; P27695; APE; APE1; APEN; APEX; APX; HAP1; REF-1; REF1;; APE
- Rabbit polyclonal to APE; 328; APEX1; 107748; P27695; APE; APE1; APEN; APEX; APX; HAP1; REF-1; REF1;; DNA-(apurinic or apyrimidinic site) lyase

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: APE	Gene Name Synonym: 328; APEX1; 107748; P27695; APE; APE1; APEN; APEX; APX; HAP1; REF-1; REF1;
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: P27695
Length (aa): N/A	Mol. Weight (Da): 35555	Chrom Location: N/A

Isotype: IgG

Immunogen: KLH conjugated synthetic peptides corresponding to amino acids 36-52 and 216-232 of human APE.

Antigen Species: Human

Positive Control: HeLa cell lysates.

Target: APE

Localization: Nuclear

Concentration: 0.5 mg/ml

Storage Buffer: Preservative: 0.02% Sodium Azide; Constituents: PBS

Application Note: WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 35 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Nuclear

Source/Host: Rabbit

Purity/Purification: Protein G purified

Clonality: Polyclonal

Crossreactivity: Human - Not yet tested in other species

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for APE ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

APE ANTIBODY TARGET DESCRIPTION:

Synonym Names for APE antibody: APE; 328; APEX1; 107748; P27695; APE; APE1; APEN; APEX; APX; HAP1; REF-1; REF1;; Rabbit polyclonal to APE; 328; APEX1; 107748; P27695; APE; APE1; APEN; APEX; APX; HAP1; REF-1; REF1;; DNA-(apurinic or apyrimidinic site) lyase

Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NFkB, Myb, HIF1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. Altered levels of APE have also been found in some cancers. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases.

Function: Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin.

Catalytic Activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Subunit: Monomer. Component of the SET complex, which also contains SET, ANP32A, HMGB2 and NME1.

Subcellular Location: Nucleus.

Similarity: Belongs to the DNA repair enzymes AP/exoA family.

APE reacts with human - not yet tested in other species.

OMIM: 107748; gene. [NCBI / EBI]

Products similar to APE antibody:

IgG

ALMS1, IgG

AIRE (isoform 1), IgG

THO complex subunit 4, IgG

ALMS1, IgG

CDw328, IgG

Protein

RPP0 Human, Protein

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: APE antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of APE antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about APE antibody, all related information, articles, resources about APE antibody are being stored on our online database. Let us know if you have questions regarding this product.

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