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| NMDA receptor 2B Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-272-196191 |
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| Related Product Names:
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NMDA receptor 2B antibody; NMDA receptor 2B; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B Glutamate receptor ionotropic NMDA2B GRIN2B hNR3 N METHYL D ASPARTATE RECE; NMDA receptor 2B
- Rabbit polyclonal to NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: NMDA receptor 2B |
Gene Name Synonym: Glutamate Receptor Ionotropic N Methyl D Aspartate 2B Glutamate receptor ionotropic NMDA2B GRIN2B hNR3 N METHYL D ASPARTATE RECE |
Gi #:
N/A |
NCBI Acc #:
NP_000825.2 |
Swiss Prot Acc #:
Q13224 |
Length (aa): N/A |
Mol. Weight (Da): 166367 |
Chrom Location: N/A |
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 Isotype: IgG
Immunogen: Amino acids 1437-1456 of mature mouse NR2B or 1463-1482 of NR2B precursor; signal is amino acid residues 1-26 [KFNGSSNGHV-YEKLSSIESDV].
Antigen Species: Mouse
Positive Control: Rat brain microsomal protein preparation
Target: NMDA receptor 2B
Storage Buffer: Phosphate-buffered saline, pH 7.6, containing 0.1% sodium azide
Application Note: For WB: Use at a concentration of 0.5-2.0 µg/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Source/Host: Rabbit
Purity/Purification: Protein A purified
Clonality: Polyclonal
Crossreactivity: Mouse - Expected to cross-react with Rat and Human - Not yet tested in other species
Format: Liquid
Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for NMDA RECEPTOR 2B ANTIBODY: |
| WB: Tested |
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| NMDA RECEPTOR 2B ANTIBODY TARGET DESCRIPTION: |
Synonym Names for NMDA receptor 2B antibody: NMDA receptor 2B; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B Glutamate receptor ionotropic NMDA2B GRIN2B hNR3 N METHYL D ASPARTATE RECE; Rabbit polyclonal to NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2
NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA).
Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity). Interacts with MAGI3.
Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue Specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family [view classification].
NMDA receptor 2B reacts with mouse - expected to cross-react with rat and human - not yet tested in other species .
OMIM: 138252; gene. [NCBI / EBI]
Pathways:
KEGG pathway: Long-term potentiation 04720
KEGG pathway: Neuroactive ligand-receptor interaction 04080
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: NMDA receptor 2B antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of NMDA receptor 2B antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NMDA receptor 2B antibody, all related information, articles, resources about NMDA receptor 2B antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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