Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
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0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
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ELISA Kits
iNOS Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-272-196371
Buy iNOS antibody -
Volume:
0.5 ml ($360.00)
Related Product Names:
- iNOS antibody; iNOS; Inducible nitric oxide synthase nitric oxide synthase 2 inducible macrophage Nos-2 Nos-II NOS2A; iNOS
- Rabbit polyclonal to iNOS; Inducible nitric oxide synthase nitric oxide synthase 2 inducible macrophage Nos-2 Nos-II NOS2A; Nitric oxide synthase, inducible
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
iNOS
Gene Name Synonym:
Inducible nitric oxide synthase nitric oxide synthase 2 inducible macrophage Nos-2 Nos-II NOS2A
Gi #:
N/A
NCBI Acc #:
NP_000616.3
Swiss Prot Acc #:
P35228
Length (aa):
N/A
Mol. Weight (Da):
131117
Chrom Location:
N/A
Isotype:
IgG
Immunogen:
Synthetic peptide derived from C-terminal of mouse iNOS.
Antigen Species:
Mouse
Positive Control:
Lung
Target:
iNOS
Localization:
Cytoplasmic
Concentration:
0.2 mg/ml
Storage Buffer:
Phosphate-buffered saline, pH 7.4, containing BSA and sodium azide
Application Note:
For IHC-P: Use at a dilution of 1:100 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Source/Host:
Rabbit
Purity/Purification:
Immunogen affinity purified
Clonality:
Polyclonal
Crossreactivity:
Human, Mouse, and Rat - Not yet tested in other species
Format:
Liquid
Storage:
Keep as concentrated solution, aliquot and store at 4C. Do not freeze.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for INOS ANTIBODY:
IHC-P: Tested
TESTING: (
secondary reagents
and
protocols
)
Not Available
INOS ANTIBODY TARGET DESCRIPTION:
Synonym Names for iNOS antibody:
iNOS; Inducible nitric oxide synthase nitric oxide synthase 2 inducible macrophage Nos-2 Nos-II NOS2A; Rabbit polyclonal to iNOS; Inducible nitric oxide synthase nitric oxide synthase 2 inducible macrophage Nos-2 Nos-II NOS2A; Nitric oxide synthase, inducible
NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Notric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti-tumor and anti-pathogenic activities. Inducible NOS (iNOS) or macrophage NOS (mNOS) is a calcium/calmodulin independent and is expressed in activated macrophages and stimulated glial cells.
Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions.
Catalytic Activity:
L-arginine + n NADPH + m O2 = citrulline + nitric oxide + n NADP+.
Cofactor:
Heme group (By similarity).
Cofactor:
Binds 1 FAD (By similarity).
Cofactor:
Binds 1 FMN (By similarity).
Cofactor:
Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme (By similarity).
Enzyme Regulation:
Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity).
Subunit:
Homodimer. Binds SLC9A3R1.
Tissue Specificity:
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
Induction:
By endotoxins and cytokines.
Similarity:
Belongs to the NOS family.
Similarity:
Contains 1 FAD-binding FR-type domain.
Similarity:
Contains 1 flavodoxin-like domain.
iNOS reacts with human, mouse, and rat - not yet tested in other species .
OMIM:
163730; gene. [
NCBI
/
EBI
]
Pathways:
KEGG pathway: Arginine and proline metabolism
00330
KEGG pathway:
Calcium
signaling pathway
04020
KEGG pathway: Long-term depression
04730
KEGG pathway: Small cell lung cancer
05222
Products similar to iNOS antibody:
IgG
p42IP4 [P421], IgG
iNOS (ready-to-use), IgG
ATM [5C2], IgG
ATM [2C1], IgG
PI 3 Kinase p85 alpha [U13], IgG
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
iNOS antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of iNOS antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about iNOS antibody, all related information, articles, resources about iNOS antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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