IKK alpha antibody, IKK alpha phospho S176, S180 Antibody, Rabbit Polyclonal Antibody

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IKK alpha phospho S176, S180 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-272-196653

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Related Product Names:

- IKK alpha antibody; IKK alpha; IKKA; TCF16; IKK alpha phospho S176, S180
- Rabbit polyclonal to IKK alpha (phospho S176 + S180); Inhibitor of nuclear factor kappa-B kinase subunit alpha

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: IKK alpha	Gene Name Synonym: IKKA; TCF16
Gi #: N/A	NCBI Acc #: NP_001269.3	Swiss Prot Acc #: O15111
Length (aa): N/A	Mol. Weight (Da): 84654	Chrom Location: N/A

Isotype: IgG

Immunogen: Synthetic phosphopeptide derived from the region of human IKK alpha that contains serine 176 and 180.

Antigen Species: Human

Target: IKK alpha

Concentration: 0.75 mg/ml

Storage Buffer: Preservative: 0.05% Sodium Azide. Constituents: PBS (without Mg2+ and Ca2+), 1mg/ml BSA. pH 7.3

Application Note: WB: Use at a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 85 kDa. When looking at the phosphorylation of endogenous proteins, we recommend that IKKalpha first be immunoprecipitated. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Source/Host: Rabbit

Purity/Purification: Immunogen affinity purified

Clonality: Polyclonal

Crossreactivity: Cross-reacts with Human. Expected to cross-react with Mouse due to sequence homology.IKKbeta has not been tested but may cross react (93% homologous) in a system expressing high levels of this protein. Not yet tested in other species.

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for IKK ALPHA ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

IKK ALPHA ANTIBODY TARGET DESCRIPTION:

Synonym Names for IKK alpha antibody: IKK alpha; IKKA; TCF16; Rabbit polyclonal to IKK alpha (phospho S176 + S180); Inhibitor of nuclear factor kappa-B kinase subunit alpha

Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNFa, and bacteria product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for the NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Catalytic Activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].

Enzyme Regulation: Activated when phosphorylated and inactivated when dephosphorylated.

Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Directly interacts with IKK-gamma/NEMO and TRPC4AP (By similarity). May interact with TRAF2. Interacts with NALP2. May interact with MAVS/IPS1.

Subcellular Location: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.

Tissue Specificity: Widely expressed.

Ptm: Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

Similarity: Contains 1 protein kinase domain.

IKK alpha phospho S176, S180 reacts with cross-reacts with human. expected to cross-react with mouse due to sequence homology.ikkbeta has not been tested but may cross react (93% homologous) in a system expressing high levels of this protein. not yet tested in other species..

OMIM: 600664; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Adipocytokine signaling pathway 04920
KEGG pathway: Apoptosis 04210
KEGG pathway: B cell receptor signaling pathway 04662
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: Epithelial cell signaling in Helicobacter pylori infection 05120
KEGG pathway: MAPK signaling pathway 04010
KEGG pathway: Pancreatic cancer 05212
KEGG pathway: Prostate cancer 05215
KEGG pathway: Small cell lung cancer 05222
KEGG pathway: T cell receptor signaling pathway 04660
KEGG pathway: Toll-like receptor signaling pathway 04620
Reactome Event:Signaling in Immune system 168256
Reactome Event:Signalling by NGF 166520

Products similar to IKK alpha antibody:

IgG

IKK alpha [14A231], IgG

IKK, IgG

Inhibitor of nuclear factor kappa-B kinase alpha subunit, IgG

IKK -alpha (Ab-23), IgG

IKK, IgG

Peptide

IKK -alpha (Phospho-Thr23) Antibody Blocking Peptide, Peptide

IKK-alpha Control Peptide, Peptide

PRODUCT INTERACTIONS:

IKK alpha phospho S176, S180 interacts with Inhibitor of nuclear factor kappa B kinase subunit beta, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKK, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKKb, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKK beta [10AG2], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKK beta [10A9B6], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Rabbit A' IKK-beta, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKK-beta Control Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-IKK beta, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-IKK beta CONTROL PEPTIDE, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappa-B essential modulator, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKK gamma [46B844], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells. kinase gamma), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKK gamma, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Rabbit anti VISA, N-term, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Rabbit anti VISA (Middle), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with SRC3, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NCOA3 [AX 15], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NCOA3 [0.T.198], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with SRC3, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF KAPPA B INHIBITOR ALPHA, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF KAPPA B INHIBITOR, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKB alpha [6A920], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKB alpha phospho S32, S36 [39A1431], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKB alpha cleaved, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with I-kappaB-alpha (Phospho-Tyr42), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with I-kappaB-alpha (Ab-42), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with I-kappaB-alpha (Ab-32/36), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IkappaB-alpha (Phospho-Ser32/Ser36) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IkappaB-alpha (Phospho-Tyr42) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFKBIA, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Rabbit anti IkB-alpha (C-terminal), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IkB-alpha (C-terminal) Control Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-IKB alpha (Human MOUSE Rat Specific) C-terminal, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKB alpha, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with IKB alpha phospho S32, S36, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with RELA, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkB p65, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Phospho-Ser529), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Ab-529), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 ( (phospho-Ser311), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Ab-311), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Phospho-Thr254), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Phospho-Ser276), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Phospho-Thr435), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Phospho-Ser468), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Phospho-Ser536), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Ab-254), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Ab-276), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB -p65 (Ab-435), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Ab-468), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NF-kappaB-p65 (Ab-536), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkappaB-p65 (Phospho-Thr254) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkappaB-p65 (Phospho-Ser276) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkappaB-p65 (Phospho-Thr435) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkappaB-p65 (Phospho-Ser468) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkappaB-p65 (Phospho-Ser536) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkappaB-p65 (Phospho-Ser529) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkappaB-p65 (phospho-Ser311) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Rabbit anti p65 (RelA) N-terminal, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Rabbit anti p65 (RelA) C-terminal, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-NFKB p65 (Rel A) phospho specific pS276, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-NFKB p65 (Rel A) phospho specific pS529, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-NFKB p65 (Rel A), IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-NFKB p65 (Rel A) N-TERMINAL SPECIFIC, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-NFKB p65 (Rel A) phospho specific pS536, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with Anti-NFKB p65 NLS specific, IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkB p65 [NF-12], IgG (GenWay Catalog #: 18-272-196653).

IKK alpha phospho S176, S180 interacts with NFkB p65, IgG (GenWay Catalog #: 18-272-196653).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: IKK alpha antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of IKK alpha antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

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