PKC zeta antibody, PKC zeta Antibody, Rabbit Polyclonal Antibody

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PKC zeta Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-272-197285

Buy PKC zeta antibody -

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Related Product Names:

- PKC zeta antibody; PKC zeta; PKC2 PRKCZ; PKC zeta
- Rabbit polyclonal to PKC zeta; PKC2 PRKCZ; Protein kinase C zeta type

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: PKC zeta	Gene Name Synonym: PKC2 PRKCZ
Gi #: N/A	NCBI Acc #: NP_001028753.1	Swiss Prot Acc #: Q05513
Length (aa): N/A	Mol. Weight (Da): 67660	Chrom Location: N/A

Isotype: IgG

Immunogen: Synthetic peptide: FEGFEYINPLLLSTEESV, corresponding to amino acids 575-592 of Human PKC zeta.

Antigen Species: Human

Target: PKC zeta

Storage Buffer: Preservative: 0.05% Sodium Azide

Application Note: Western blot: use at a dilution of 1/100 (enhanced chemiluminescence). Predicted molecular weight: 71 kDa. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. If a less sensitive detecting system, such as alkaline phosphatase, is to be employed, the dilution of the antibody should be decreased.

Source/Host: Rabbit

Purity/Purification: Whole antiserum

Clonality: Polyclonal

Crossreactivity: Cross-reacts with Human, Mouse and Rat. Expected to cross-react with all Mammals due to sequence homology. Not yet tested in other species.

Format: Rabbit antiserum containing 0.05% sodium azide.

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for PKC ZETA ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

PKC ZETA ANTIBODY TARGET DESCRIPTION:

Synonym Names for PKC zeta antibody: PKC zeta; PKC2 PRKCZ; Rabbit polyclonal to PKC zeta; PKC2 PRKCZ; Protein kinase C zeta type

Function: This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.

Function: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.

Catalytic Activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme Regulation: Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation.

Subunit: Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB.

Subcellular Location: Cytoplasm. Endosome. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes.

Tissue Specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis.

Domain: The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B.

Domain: The C1 domain does not bind the diacylglycerol (DAG).

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

Similarity: Contains 1 AGC-kinase C-terminal domain.

Similarity: Contains 1 OPR domain.

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger.

Similarity: Contains 1 protein kinase domain.

PKC zeta reacts with cross-reacts with human, mouse and rat. expected to cross-react with all mammals due to sequence homology. not yet tested in other species..

OMIM: 176982; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: Tight junction 04530
KEGG pathway: Type II diabetes mellitus 04930

Products similar to PKC zeta antibody:

IgG

PKC zeta, IgG

PRODUCT INTERACTIONS:

PKC zeta interacts with PKC-t Human, Protein (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC-theta (Phospho-Ser695), IgG (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC-theta (Phospho-Ser676), IgG (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC-theta (Ab-695), IgG (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC-theta (Ab-676), IgG (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC-theta(Phospho-Ser695) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC-theta(Phospho-Ser676) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC theta phospho S676, IgG (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC theta phospho T538, IgG (GenWay Catalog #: 18-272-197285).

PKC zeta interacts with PKC theta phospho S695, IgG (GenWay Catalog #: 18-272-197285).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: PKC zeta antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of PKC zeta antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PKC zeta antibody, all related information, articles, resources about PKC zeta antibody are being stored on our online database. Let us know if you have questions regarding this product.

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