Dab1 antibody, Dab1 phospho Y198 Antibody, Rabbit Polyclonal Antibody

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Dab1 phospho Y198 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-272-197449

Buy Dab1 antibody -

Volume:

Related Product Names:

- Dab1 antibody; Dab1; 115209; OMA1; Q96E52; 2010001O09Rik; DAB1; FLJ33782; MPRP-1; YKR087C; ZMPOMA1; 1600; DAB1; 603448; O75553;; Dab1 phospho Y198
- Rabbit polyclonal to Dab1 ( phospho Y198 ); 115209; OMA1; Q96E52; 2010001O09Rik; DAB1; FLJ33782; MPRP-1; YKR087C; ZMPOMA1; 1600; DAB1; 603448; O75553;; Disabled homolog 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Dab1	Gene Name Synonym: 115209; OMA1; Q96E52; 2010001O09Rik; DAB1; FLJ33782; MPRP-1; YKR087C; ZMPOMA1; 1600; DAB1; 603448; O75553;
Gi #: N/A	NCBI Acc #: NP_066566.3	Swiss Prot Acc #: O75553
Length (aa): N/A	Mol. Weight (Da): 63775	Chrom Location: N/A

Isotype: IgG

Immunogen: Synthetic phosphopeptide derived from the region of human Dab1 that contains tyrosine 198.

Antigen Species: Human

Positive Control: Human Embryonic Kidney (HEK293) cells transfected with wild-type mouse Dab1 protein

Target: Dab1

Storage Buffer: Preservative: 0.05% Sodium Azide; Constituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3

Application Note: WB: Use at a dilution of 1/1000. Detects a band of approximately 80 kDa. When examining phosphorylation of endogenous Dab1 protein we recommend that Dab1 protein first be immunoprecipitated. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Source/Host: Rabbit

Purity/Purification: Protein A purified

Clonality: Polyclonal

Crossreactivity: Cross-reacts with Human and Mouse. Expected to cross-react with Chicken (100% identity with immunogen), Rat (100% identity with immunogen) due to sequence homology. Not yet tested in other species.

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for DAB1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

DAB1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Dab1 antibody: Dab1; 115209; OMA1; Q96E52; 2010001O09Rik; DAB1; FLJ33782; MPRP-1; YKR087C; ZMPOMA1; 1600; DAB1; 603448; O75553;; Rabbit polyclonal to Dab1 ( phospho Y198 ); 115209; OMA1; Q96E52; 2010001O09Rik; DAB1; FLJ33782; MPRP-1; YKR087C; ZMPOMA1; 1600; DAB1; 603448; O75553;; Disabled homolog 1

Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled 1 gene locus which is mutated in scrambler and yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects and ataxia, disruption of neuronal migration, and severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases (e.g., Fyn). Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 tyrosine 198 is a major site for reelin-induced Src family kinase-mediated phosphorylation in embryonic neurons.

Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).

Subunit: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.

Domain: The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.

Ptm: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling (By similarity).

Similarity: Contains 1 PID domain.

Dab1 phospho Y198 reacts with cross-reacts with human and mouse. expected to cross-react with chicken (100% identity with immunogen), rat (100% identity with immunogen) due to sequence homology. not yet tested in other species..

OMIM: 603448; gene. [NCBI / EBI]

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Dab1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Dab1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Dab1 antibody, all related information, articles, resources about Dab1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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