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| ACHE (HRP) Antibody, Goat Polyclonal Antibody |
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| Catalog Number: 18-272-197650 |
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| Related Product Names:
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ACHE antibody; ACHE; 540446; ACHE;; ACHE (HRP)
- Goat polyclonal to Acetylcholinesterase ( HRP ); 540446; ACHE;; Acetylcholinesterase |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: ACHE |
Gene Name Synonym: 540446; ACHE; |
Gi #:
N/A |
NCBI Acc #:
NP_000656.1 |
Swiss Prot Acc #:
P22303 |
Length (aa): N/A |
Mol. Weight (Da): 67796 |
Chrom Location: N/A |
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 Isotype: IgG
Immunogen: Acetyl Cholinesterase [Bovine Erythrocytes]
Antigen Species: Bovine
Target: ACHE
Conjugation: HRP
Conjugation Note: Horseradish Peroxidase (HRP).
Concentration: 10 mg/ml
Purification Note: This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer
Storage Buffer: Stabilizer: 10 mg/ml Bovine Serum Albumin (BSA) IgG and Protease free Preservative: 0.01% (w/v) Gentamicin Sulfate Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Application Note: Suitable for immunoblotting (western or dot blot), ELISA (1:1000), immunoperoxidase electron microscopy and immunohistochemistry as well as other peroxidase-antibody based enzymatic assays.
Source/Host: Goat
Purity/Purification: IgG fraction
Clonality: Polyclonal
Crossreactivity: Cross-reacts with Cow. Not yet tested in other species.
Format: Liquid
Storage: Store at +4C short term. Aliquot and store at -20C or -80C
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for ACHE ANTIBODY: |
| ELISA, IHC-F, IM, WB: Tested |
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| ACHE ANTIBODY TARGET DESCRIPTION: |
Synonym Names for ACHE antibody: ACHE; 540446; ACHE;; Goat polyclonal to Acetylcholinesterase ( HRP ); 540446; ACHE;; Acetylcholinesterase
Cholinergic neurotransmission occurs in motor, autonomic and central nervous synapses and requires very rapid inactivation of its transmitter, acetylcholine (ACh). Acetylcholinesterase (AChE) rapidly hydrolyzes ACh to acetate and choline, thereby inactivating it. AChE is found in the neuromuscular junction anchored to the basal lamina which runs between the nerve terminal and muscle membrane. AChE is also found outside the nervous and neuromuscular system in blood, lymph, germ and liver cells suggesting a role for AChE not related to cholinergic transmission. Another less specific cholinesterase, butyrylcholinesterase (BChE), seems to contribute to the regulation of the ACh concentration in the synaptic cleft.
Function: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Catalytic Activity: Acetylcholine + H2O = choline + acetate.
Subunit: Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.
Subcellular Location: Cell junction, synapse. Secreted (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
Subcellular Location: Isoform T: Nucleus. Note=Only observed in apoptotic nuclei.
Subcellular Location: Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity).
Tissue Specificity: Isoform H is highly expressed in erythrocytes.
Polymorphism: ACHE is responsible for the Yt blood group system. The molecular basis of the Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).
Disease: Behaves as an amyloid-promoting factor to promote the formation of amyloid plaques in Alzheimer disease.
Similarity: Belongs to the type-B carboxylesterase/lipase family.
ACHE (HRP) reacts with cross-reacts with cow. not yet tested in other species..
OMIM: 100740; gene+phenotype. [NCBI / EBI]
112100; phenotype. [NCBI / EBI]
Pathways:
KEGG pathway: Glycerophospholipid metabolism 00564
Products similar to ACHE antibody:
IgG
 TNF alpha [MP6-XT22] (PE), IgG
TNF alpha, IgG
TNF alpha [F6C5 ], IgG
TNF alpha, IgG
TNF alpha [2C8], IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: ACHE antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of ACHE antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ACHE antibody, all related information, articles, resources about ACHE antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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