Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
|
ELISA Kits
TNF receptor II Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-272-197676
Buy TNF receptor II antibody -
Volume:
0.5 ml ($460.00)
Related Product Names:
- TNF receptor II antibody; TNF receptor II; CD120b,; TNF receptor II
- Rabbit polyclonal to TNF Receptor II; 7133; TNFRSF1B; 191191; P20333; CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR2; TNFR80; p75; p75TNFR; CD 120b antibody CD120b antibody CD120b antigen antibody Etanercept antibody p75 antibody p75TNFR antibody p80 TNF alpha receptor antibody TBP2 antibody
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
TNF receptor II
Gene Name Synonym:
CD120b,
Gi #:
N/A
NCBI Acc #:
NP_001057.1
Swiss Prot Acc #:
P20333
Length (aa):
N/A
Mol. Weight (Da):
48291
Chrom Location:
N/A
Isotype:
IgG
Specificity:
The antibody reacts with the extra-cellular part of the TNF-R II and with the soluble receptor. TNF-R II is present on most cell types and is considered to play a role in cell stimulation by TNF-alpha. TNF-R II molecule is shown to be responsible for stimulation of activated T-lymphocytes by TNF-alpha.
Target:
TNF receptor II
Localization:
Type I membrane protein and secreted
Concentration:
Lot specific and is stated on the vial.
Storage Buffer:
Phosphate buffered saline containing 0.02% sodium azide and 0.1% BSA
Application Note:
The antibody is an agonistic antibody useful for detection of TNF-R II. It can be used for immunoassays, Western blotting, flow cytometry and immunoprecipitation. The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of TNF-a. Minimal crossreactivity is present with human TNF-a. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Cellular Localization:
Type I membrane protein and secreted
Source/Host:
Rabbit
Purity/Purification:
IgG fraction
Clonality:
Polyclonal
Crossreactivity:
Human - Not yet tested in other species
Format:
Liquid
Storage:
Keep as concentrated solution, aliquot and store at 4C.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for TNF RECEPTOR II ANTIBODY:
FACS, IA, IP, WB: Tested
TESTING: (
secondary reagents
and
protocols
)
Not Available
TNF RECEPTOR II ANTIBODY TARGET DESCRIPTION:
Synonym Names for TNF receptor II antibody:
TNF receptor II; CD120b,; Rabbit polyclonal to TNF Receptor II; 7133; TNFRSF1B; 191191; P20333; CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR2; TNFR80; p75; p75TNFR; CD 120b antibody CD120b antibody CD120b antigen antibody Etanercept antibody p75 antibody p75TNFR antibody p80 TNF alpha receptor antibody TBP2 antibody
TNF-R II is present on most cell types and is considered to play a role in cell stimulation by TNF-a. TNF-R II molecule is shown to be responsible for stimulation of activated T-lymphocytes by TNF-a.
Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subunit:
Binds to TRAF2.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform 2: Secreted.
Subcellular Location:
Tumor necrosis factor-binding protein 2: Secreted.
Ptm:
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
Ptm:
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
Pharmaceutical:
Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.
Similarity:
Contains 4 TNFR-Cys repeats.
TNF receptor II reacts with human - not yet tested in other species.
OMIM:
191191; gene. [
NCBI
/
EBI
]
Products similar to TNF receptor II antibody:
IgG
TNF receptor II, IgG
TNF receptor II [HM102], IgG
TNF receptor II (ready-to-use), IgG
PRODUCT INTERACTIONS:
TNF receptor II
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 18-272-197676)
.
TNF receptor II
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 18-272-197676)
.
TNF receptor II
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 18-272-197676)
.
TNF receptor II
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 18-272-197676)
.
TNF receptor II
interacts
with
TRAF2 [33A1293], IgG
(GenWay Catalog #: 18-272-197676)
.
TNF receptor II
interacts
with
Rabbit anti TRAF-2, IgG
(GenWay Catalog #: 18-272-197676)
.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
TNF receptor II antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of TNF receptor II antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TNF receptor II antibody, all related information, articles, resources about TNF receptor II antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.
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