Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
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ELISA Kits
alpha 1 Antitrypsin Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-272-197738
Buy alpha 1 Antitrypsin antibody -
Volume:
0.5 ml ($320.00)
Related Product Names:
- alpha 1 Antitrypsin antibody; alpha 1 Antitrypsin; 5265; SERPINA1; 107400; P01009; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275;; alpha 1 Antitrypsin
- Rabbit polyclonal to alpha 1 Antitrypsin; 5265; SERPINA1; 107400; P01009; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275;; Alpha-1-antitrypsin
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
alpha 1 Antitrypsin
Gene Name Synonym:
5265; SERPINA1; 107400; P01009; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275;
Gi #:
N/A
NCBI Acc #:
NP_000286.3
Swiss Prot Acc #:
P01009
Length (aa):
N/A
Mol. Weight (Da):
46737
Chrom Location:
N/A
Isotype:
Unknown
Immunogen:
Alpha-1-antitrypsin isolated from human serum.
Antigen Species:
Human
Specificity:
The antibody is specific against human alpha-1-antitrypsin. This antibody stains macrophages in human tissues and does not stain any other cell type.
Positive Control:
Tonsil
Target:
alpha 1 Antitrypsin
Localization:
Cytoplasmic
Storage Buffer:
PBS, ph7.2 containing 0.05% sodium azide
Application Note:
For IHC-P: Use at a dilution of 1:25-1:50 in an ABC method. An incubation of 30 minutes at RT is recommended. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Cellular Localization:
Secreted
Source/Host:
Rabbit
Purity/Purification:
Protein A purified
Clonality:
Polyclonal
Crossreactivity:
Human - Cross-reacts with a wide range of mammalian species - Not tested in other species
Format:
Liquid
Storage:
Keep as concentrated solution, aliquot and store at 4C.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for ALPHA 1 ANTITRYPSIN ANTIBODY:
IHC-P: Tested
TESTING: (
secondary reagents
and
protocols
)
Not Available
ALPHA 1 ANTITRYPSIN ANTIBODY TARGET DESCRIPTION:
Synonym Names for alpha 1 Antitrypsin antibody:
alpha 1 Antitrypsin; 5265; SERPINA1; 107400; P01009; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275;; Rabbit polyclonal to alpha 1 Antitrypsin; 5265; SERPINA1; 107400; P01009; A1A; A1AT; AAT; MGC23330; MGC9222; PI; PI1; PRO2275;; Alpha-1-antitrypsin
alpha 1 Antitrypsin is a plasma protein synthesised in the liver. It consists of a single polypeptide chain and has a molecular weight of 52 kDa. A serine protease inhibitor, its primary function is the protection of lung tissue from the action of neutrophil elastase. The average level of alpha 1 Antitrypsin in plasma is 1.3 g/l.
Function:
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Subcellular Location:
Secreted.
Tissue Specificity:
Plasma.
Domain:
The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Ptm:
Several isomers are observed, resulting from the combination of different N-linked glycan structures and mature N-terminus. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary whereas glycan at Asn-70 is di-antennary with trace amounts of tri-antennary, and glycan at Asn-271 is exclusively di-antennary. The structure of the antennas is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennas are fucosylated, which forms a Lewis-X determinant.
Ptm:
Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418.
Polymorphism:
The sequence shown is that of the M1V allele which is the most common form of PI (44 to 49%). Other frequent alleles are: M1A 20 to 23%; M2 10 to 11%; M3 14 to 19%.
Disease:
The major physiological function of AAT is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). A hereditary deficiency of AAT, is associated with a 20-30 fold increased risk of developing chronic obstructive pulmonary disease.
Disease:
Deficiency of the normal inhibitor in individuals homozygous for allele Z or M-Malton can result in the development of chronic emphysema or infantile liver cirrhosis.
Disease:
Variant Pittsburgh is the cause of bleeding diathesis.
Miscellaneous:
The aberrant form is found in the plasma of chronic smokers, and persists after smoking is ceased. It can still be found ten years after smoking has ceased.
Similarity:
Belongs to the serpin family.
alpha 1 Antitrypsin reacts with human - cross-reacts with a wide range of mammalian species - not tested in other species .
OMIM:
107400; gene+phenotype. [
NCBI
/
EBI
]
Pathways:
KEGG pathway: Complement and coagulation cascades
04610
Reactome Event:Hemostasis
109582
Products similar to alpha 1 Antitrypsin antibody:
Amino_Acids
Angiotensin Acetate, Amino_Acids
Human alpha 1-Antitrypsin, ELISA_Kits
Rat Antithrombin III, ELISA_Kits
Mouse Alpha 1-Antitrypsin, ELISA_Kits
CG beta [HCG-60], IgG
PRODUCT INTERACTIONS:
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
alpha 1 Antitrypsin antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of alpha 1 Antitrypsin antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about alpha 1 Antitrypsin antibody, all related information, articles, resources about alpha 1 Antitrypsin antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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