Neutrophil elastase antibody, Neutrophil elastase Antibody, Rabbit Polyclonal Antibody

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Neutrophil elastase Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-272-197794

Buy Neutrophil elastase antibody -

Volume:

Related Product Names:

- Neutrophil elastase antibody; Neutrophil elastase; Bone Marrow Serine Protease; ELA2; Elastase 2 neutrophil; HLE; HNE; Leukocyte Elastase Precursor; Medullasin; PMN Elastase; Poly; Neutrophil elastase
- Rabbit polyclonal to Neutrophil Elastase; Leukocyte elastase

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Neutrophil elastase	Gene Name Synonym: Bone Marrow Serine Protease; ELA2; Elastase 2 neutrophil; HLE; HNE; Leukocyte Elastase Precursor; Medullasin; PMN Elastase; Poly
Gi #: N/A	NCBI Acc #: NP_001963.1	Swiss Prot Acc #: P08246
Length (aa): N/A	Mol. Weight (Da): 28518	Chrom Location: N/A

Isotype: IgG

Immunogen: Elastase (Human Neutrophil).

Antigen Species: Human

Target: Neutrophil elastase

Localization: Cytoplasmic and Secreted

Concentration: 11.45 mg/ml

Purification Note: Ammonium sulfate precipitation. Single arc on IEP of neutrophil granule extract and human neutrophil elastase.

Storage Buffer: Preservative: 0.1% Sodium Azide. Constituents: PBS. pH 7.5

Application Note: I-ELISA: >1/1000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Cytoplasmic and Secreted

Source/Host: Rabbit

Purity/Purification: Protein A purified

Clonality: Polyclonal

Crossreactivity: Human - Not yet tested in other species

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for NEUTROPHIL ELASTASE ANTIBODY:

I-ELISA: Tested

TESTING: (secondary reagents and protocols )

Not Available

NEUTROPHIL ELASTASE ANTIBODY TARGET DESCRIPTION:

Synonym Names for Neutrophil elastase antibody: Neutrophil elastase; Bone Marrow Serine Protease; ELA2; Elastase 2 neutrophil; HLE; HNE; Leukocyte Elastase Precursor; Medullasin; PMN Elastase; Poly; Rabbit polyclonal to Neutrophil Elastase; Leukocyte elastase

Elastases form a subfamily of serine proteases that hydrolyse many proteins in addition to elastin. Neutrophil elastase (elastase 2) hydrolyses proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Function: Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.

Catalytic Activity: Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.

Subunit: Interacts with NOTCH2NL.

Tissue Specificity: Bone marrow cells.

Disease: Defects in ELA2 are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.

Disease: Defects in ELA2 are the cause of autosomal dominant severe congenital neutropenia type 1 (SCN1) [MIM:202700]. Severe congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.

Similarity: Belongs to the peptidase S1 family. Elastase subfamily [view classification].

Similarity: Contains 1 peptidase S1 domain [view classification].

Neutrophil elastase reacts with human - not yet tested in other species.

OMIM: 130130; gene. [NCBI / EBI]
162800; phenotype. [NCBI / EBI]
202700; phenotype. [NCBI / EBI]

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Precautions: Neutrophil elastase antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Neutrophil elastase antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Neutrophil elastase antibody, all related information, articles, resources about Neutrophil elastase antibody are being stored on our online database. Let us know if you have questions regarding this product.

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