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ER alpha Antibody, Mouse Polyclonal Antibody Printer Friendly Datasheet
Catalog Number: 18-272-198041
Buy ER alpha antibody - Volume:   
  Related Product Names:
- ER alpha antibody; ER alpha; ERalpha, estroegen receptor a, oestrogen receptor, era, er; ER alpha
- Mouse polyclonal antiserum to estrogen receptor alpha; 2099; ESR1; 133430; P03372; DKFZp686N23123; ER; ESR; ESRA; Era; NR3A1; major ORF; DKFZp686N23123 antibody ER alpha antibody ER antibody Era antibody ESR 1 antibody ESR antibody ESR1 antibody ESRA antibody Estradiol receptor antibody Estrogen receptor 1 a
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
 Gene Name: ER alpha  Gene Name Synonym: ERalpha, estroegen receptor a, oestrogen receptor, era, er

 Gi #: N/A
 NCBI Acc #: NP_000116.2
 Swiss Prot Acc #: P03372

 Length (aa): N/A
 Mol. Weight (Da): 66216
 Chrom Location: N/A
 Isotype: IgG

 Immunogen: The region encoding amino acids 1-190 expressed in E. coli.

 Specificity: Eralpha1 is specific for human ER-alpha, a 65 kDa protein and a member of the steroid family of nuclear receptors. ER is a ligand activated transcription factor.

 Positive Control: MCF7

 Target: ER alpha

 Localization: Nuclear

 Purification Note: Antiserum

 Storage Buffer: N/A

 Application Note: For IP: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Predicted molecular weight: 68 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

 Target protein molecular weight: 65

 Expression system: pQE

 Source/Host: Mouse

 Purity/Purification: Unpurified

 Clonality: Polyclonal

 Crossreactivity: Human - Not yet tested in other species

 Format: Liquid

 Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

 Shipping: Products may be shipped on ice pack or dry ice.
 APPLICATIONS for ER ALPHA ANTIBODY:
 IP, WB: Tested
 TESTING: (secondary reagents and protocols )
 Not Available
 ER ALPHA ANTIBODY TARGET DESCRIPTION:
Synonym Names for ER alpha antibody: ER alpha; ERalpha, estroegen receptor a, oestrogen receptor, era, er; Mouse polyclonal antiserum to estrogen receptor alpha; 2099; ESR1; 133430; P03372; DKFZp686N23123; ER; ESR; ESRA; Era; NR3A1; major ORF; DKFZp686N23123 antibody ER alpha antibody ER antibody Era antibody ESR 1 antibody ESR antibody ESR1 antibody ESRA antibody Estradiol receptor antibody Estrogen receptor 1 a

The estrogen receptor (ER) is a 65a protein and is a member of the steroid family of nuclear receptors. ER is a ligand activated transcription factor and, when bound to the estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) sequences. When bound to DNA, ER can positively or negatively regulate gene transcription through the recruitment of coactivator (e.g. SRC-1) or corepressor (e.g. NCoR) proteins.

Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Subunit: Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2 and FAM120B. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.

Subcellular Location: Nucleus.

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.

Ptm: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.

Ptm: Glycosylated; contains N-acetylglucosamine, probably O-linked.

Polymorphism: Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily.

Similarity: Contains 1 nuclear receptor DNA-binding domain.

ER alpha reacts with human - not yet tested in other species .

OMIM: 133430; gene. [NCBI / EBI]

Products similar to ER alpha antibody:
 IgG
    ER alpha (ready-to-use), IgG
    ER alpha [1F3], IgG
    ER alpha [B409 (AER320)], IgG
    ER alpha [B406 (AER314)], IgG
    ER alpha [B403 (AER308)], IgG
 PRODUCT INTERACTIONS:
 ER alpha interacts with BRCA1 phospho S1387, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 phospho S1524, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [9F12], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [MS110], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [MS13], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [17F8], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [17F8], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [8F7], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [8F7], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [6B4], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [6B4], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 (Phospho-Ser1524), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 (Phospho-Ser1423), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 (Ab-1423), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 (Phospho-Ser1524) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 (Phospho-Ser1423) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [9F12], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1 [GLK-2], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with BRCA1, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FOXO1A (forkhead box O1A), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [7H11], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [7H11], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [4E7], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [14E4], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR (Phospho-Ser256), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR (Phospho-Ser319), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR (Ab-256), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR (Ab-319), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR (Phospho-Ser256) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR (Phospho-Ser319) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [7H3], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [7H3], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [4E7], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FKHR [14E4], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with FOXO1A, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with MDM2 [2A10], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with MDM2 [SMP14], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with MDM2 [SMP14], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with Rabbit anti Mouse MDM2 pS185, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with MDM2 [HDM2-323], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with MDM2 [MD-219], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with MDM2 (ready-to-use), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with SRC3, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with NCOA3 [AX 15], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with NCOA3 [0.T.198], IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with SRC3, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with SRC3, IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, Protein (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with PRMT2 (protein arginine methyltransferase 2), IgG (GenWay Catalog #: 18-272-198041).
 ER alpha interacts with VAV3 phospho Y173, IgG (GenWay Catalog #: 18-272-198041).
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ER alpha antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ER alpha antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ER alpha antibody, all related information, articles, resources about ER alpha antibody are being stored on our online database. Let us know if you have questions regarding this product.

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