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| p107 Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-272-198253 |
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| Related Product Names:
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p107 antibody; p107; 107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107); p107
- Rabbit Polyclonal to p107; 107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107); 107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107) |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: p107 |
Gene Name Synonym: 107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107) |
Gi #:
N/A |
NCBI Acc #:
NP_002886.2 |
Swiss Prot Acc #:
P28749 |
Length (aa): N/A |
Mol. Weight (Da): 120847 |
Chrom Location: N/A |
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 Immunogen: Synthetic peptide corresponding to C-terminus of human p107 protein
Antigen Species: Human
Positive Control: NIH3T3, SK-BR-3, MCF-7 cells
Target: p107
Localization: Nuclear
Concentration: 1 mg/ml
Storage Buffer: 10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide
Application Note: For WB: Use at a dilution of 1:1,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Cellular Localization: Nuclear
Source/Host: Rabbit
Purity/Purification: Protein A affinity purified
Clonality: Polyclonal
Crossreactivity: Human, Mouse, and Rat - Not yet tested in other species
Format: Liquid
Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for P107 ANTIBODY: |
| WB: Tested |
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| P107 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for p107 antibody: p107; 107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107); Rabbit Polyclonal to p107; 107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107); 107 retinoblastoma -associated protein CP107 MGC40006 p107 P107 PRB1 retinoblastoma-like 1 (p107)
The pocket protein family consists of three structurally and functionally related proteins, Rb (retinoblastoma), p107, and p130. This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family. The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression. Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation . While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F. Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb. Rb, p107, and p130 each contain a conserved 'A/B pocket', which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A.
Function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Subunit: Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with JARID1A.
Subcellular Location: Nucleus (Potential).
Ptm: Exists in both phosphorylated and unphosphorylated forms, and T, but not E1A, binds only to the unphosphorylated form. Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.
Similarity: Belongs to the retinoblastoma protein (RB) family.
p107 reacts with human, mouse, and rat - not yet tested in other species .
OMIM: 116957; gene. [NCBI / EBI]
Pathways:
KEGG pathway: Cell cycle 04110
KEGG pathway: TGF-beta signaling pathway 04350
Products similar to p107 antibody:
IgG
 E2F4 [TFE42], IgG
c-Kit [104D2], IgG
c-Kit phospho Y730, IgG
c-Kit (ready-to-use), IgG
CD28 [CD28.2], IgG
Protein
P40, Protein
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| PRODUCT INTERACTIONS: |
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: p107 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of p107 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about p107 antibody, all related information, articles, resources about p107 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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