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| Cullin 3 Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-272-198276 |
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| Related Product Names:
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Cullin 3 antibody; Cullin 3; 8452; CUL3; 603136; Q13618;; Cullin 3
- Rabbit Polyclonal to Cullin - 3 ( CUL - 3 ); 8452; CUL3; 603136; Q13618;; Cullin-3 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: Cullin 3 |
Gene Name Synonym: 8452; CUL3; 603136; Q13618; |
Gi #:
N/A |
NCBI Acc #:
NP_003581.1 |
Swiss Prot Acc #:
Q13618 |
Length (aa): N/A |
Mol. Weight (Da): 88930 |
Chrom Location: N/A |
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 Immunogen: A synthetic peptide from the N-terminus of human Cullin-3 protein.
Antigen Species: Human
Positive Control: Tonsil
Target: Cullin 3
Localization: Nuclear
Concentration: 1 mg/ml
Storage Buffer: 10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide
Application Note: For IHC-P: Use at a dilution of 1:400. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Cellular Localization: Nuclear
Source/Host: Rabbit
Purity/Purification: Protein A affinity purified
Clonality: Polyclonal
Crossreactivity: Human and Mouse - Not yet tested in other species
Format: Liquid
Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for CULLIN 3 ANTIBODY: |
| IHC-P: Tested |
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| CULLIN 3 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for Cullin 3 antibody: Cullin 3; 8452; CUL3; 603136; Q13618;; Rabbit Polyclonal to Cullin - 3 ( CUL - 3 ); 8452; CUL3; 603136; Q13618;; Cullin-3
CUL-3 is a member of the family of human cullin genes (CUL-1, -2, -3, -4a,-4b, and -5), homologous to the S. cerevisiae cdc53 gene. Cullin-3 is proposed to be a part of E3 protein-ubiqutin ligase.
Function: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the susbstrate recognition component. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, H2AFY and DAXX, and probably GLI2 or GLI3. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition.
Pathway: Protein modification; protein ubiquitination.
Subunit: Forms neddylation-dependent homodimers. Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein acting as both, adapter to cullin and substrate recognition subunit. The BCR complex may be active as a heterodimeric complex, in which NEDD8, covalently attached to one CUL3 molecule, binds to the C-terminus of a second CUL3 molecule. Interacts with RBX1, RNF7, CYCE and TIP120A/CAND1. Part of the BCR(SPOP) containing SPOP. Part of the probable BCR(KLHL9-KLHL13) complex with BTB domain proteins KLHL9 and KLHL13. Part of the BCR(KBTBD10) complex containing KBTBD10. Part of the BCR(ENC1) complex containing ENC1. Part of a complex consisting of BMI1/PCGF4, CUL3 and SPOP. Part of a complex consisting of H2AFY, CUL3 and SPOP. Interacts with KLHL9, KLHL13, GAN, ZBTB16, KLHL21, KLHL3, KLHL15, KLHL20, C16orf44, GMCL1L, BTBD1. Part of a complex that contains CUL3, RBX1 and GAN.
Subcellular Location: Nucleus. Golgi apparatus.
Tissue Specificity: Widely expressed.
Ptm: Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin-protein ligase activity of the BCR complex. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
Similarity: Belongs to the cullin family.
Cullin 3 reacts with human and mouse - not yet tested in other species .
OMIM: 603136; gene. [NCBI / EBI]
Pathways:
KEGG pathway: Ubiquitin mediated proteolysis 04120
Products similar to Cullin 3 antibody:
IgG
 cullin 3 (CUL3), IgG
Rabbit anti Cul3 (a.a. 1-12), IgG
Anti-Human Cul3 (N-terminal specific), IgG
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| PRODUCT INTERACTIONS: |
Cullin 3 interacts with TIP120A, IgG (GenWay Catalog #: 18-272-198276).
Cullin 3 interacts with Rabbit anti CAND1, N-terminal, IgG (GenWay Catalog #: 18-272-198276).
Cullin 3 interacts with Anti-Human CAND1 (N-terminal specific), IgG (GenWay Catalog #: 18-272-198276).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: Cullin 3 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of Cullin 3 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Cullin 3 antibody, all related information, articles, resources about Cullin 3 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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