Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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Y
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Peptides
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Secondary Antibodies
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ELISA Kits
Calcium/calmodulin-dependent protein kinase type II alpha chain Antibody, Rabbit Serum Antibody
Catalog Number: 17-662-20008
Buy Camk2a antibody -
Volume:
0.1 ml ($290.00)
Related Product Names:
- Camk2a antibody; Camk2a; PKCCD; PK2CDD; Calcium/calmodulin-dependent protein kinase type II alpha chain
- EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha; Calcium/calmodulin-dependent protein kinase II alpha subunit [Rattus norvegicus]
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
Camk2a
Gene Name Synonym:
PKCCD; PK2CDD
Gi #:
6978593
NCBI Acc #:
NP_037052.1
Swiss Prot Acc #:
P11275
Length (aa):
478
Mol. Weight (Da):
54115
Chrom Location:
18q11
Immunogen:
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr305 found in rat brain CaM Kinase II. The sequence of the immunogen is identical in bovine, chicken, human, mouse, rat and Xenopus.
Antibody Specificity:
Specific for the ~50k a-CaM Kinase II and the ~60k ß-CaM Kinase II phosphorylated at Thr305 in Western blots of rat brain lysates. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
Source/Host:
Rabbit
Clonality:
Serum
Crossreactivity:
Cow, chicken, human, mouse, rat, xenopus
Storage:
4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.
Stability:
6-12 months at -20 degree C.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for CAMK2A ANTIBODY:
WB: Tested
ELISA, ICC, IHC: Not Tested
TESTING: (
secondary reagents
and
protocols
)
Western Blot:
Western Blot of 10 mg of rat brain lysate showing specific immunolabeling of a- and b-CaM Kinase II phosphorylated at Thr305. The labeling by the antibody to CaM Kinase II Thr305 is specifically blocked by the Thr305 phosphopeptide used as antigen. The corresponding dephosphopeptide did not block the immunolabeling (not shown). ( anti-Camk2a )
Camk2a antibody Western Blot image
CAMK2A ANTIBODY TARGET DESCRIPTION:
Synonym Names for Camk2a antibody:
Camk2a; PKCCD; PK2CDD; EC 2.7.11.17; CaM-kinase II alpha chain; CaM kinase II alpha subunit; CaMK-II subunit alpha; Calcium/calmodulin-dependent protein kinase II alpha subunit [Rattus norvegicus]
Function:
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
Catalytic Activity:
ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:
Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.
Subunit:
CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Binds SYN1. Interacts with SYNGAP1 and MPDZ.
Similarity:
Belongs to the Ser/Thr protein kinase family. CaMK subfamily.
Similarity:
Contains 1 protein kinase domain.
Calcium/calmodulin-dependent protein kinase type II alpha chain reacts with cow, chicken, human, mouse, rat, xenopus.
Pathways:
KEGG pathway:
Calcium
signaling pathway
04020
KEGG pathway: Glioma
05214
KEGG pathway: GnRH signaling pathway
04912
KEGG pathway: Long-term potentiation
04720
KEGG pathway: Olfactory transduction
04740
KEGG pathway: Wnt signaling pathway
04310
Products similar to Camk2a antibody:
IgG
CaMK II, IgG
CaMKII, IgG
Calcium/calmodulin-dependent protein kinase type II alpha chain, IgG
CaMKII alpha phospho T286, IgG
CaMKII (Phospho-Thr286) Antibody Blocking Peptide, Peptide
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for CAMK2A ANTIBODY:
Background references for antibody target are not specific to GenWay products
[1]
Bayer,K.U., LeBel,E., McDonald,G.L., O'Leary,H., Schulman,H. and De Koninck,P.
Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B
[2]
Kamata,A., Takeuchi,Y. and Fukunaga,K., et al.
Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II and expression of brain-derived neurotrophic factor mRNAs in the substantia nigra
[3]
Ahmed,R., Zha,X.M., Green,S.H. and Dailey,M.E., et al.
Synaptic activity and F-actin coordinately regulate CaMKIIalpha localization to dendritic postsynaptic sites in developing hippocampal slices
[4]
Price,T.J., Jeske,N.A., Flores,C.M. and Hargreaves,K.M., et al.
Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons
[5]
Robison,A.J., Bass,M.A., Jiao,Y., MacMillan,L.B., Carmody,L.C., Bartlett,R.K. and Colbran,R.J.
Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
[6]
, Lin C.R., Kapiloff M.S., Durgerian S., Tatemoto K., Russo A.F., Hanson P., Schulman H., Rosenfeld M.G.
Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.
[7]
, Bulleit R.F., Bennett M.K., Molloy S.S., Hurley J.B., Kennedy M.B.
Conserved and variable regions in the subunits of brain type II Ca2+/calmodulin-dependent protein kinase.
[8]
, Hanley R.M., Means A.R., Ono T., Kemp B.E., Burgin K.E., Waxham N., Kelly P.T.
Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II.
[9]
, Sunyer T., Sahyoun N.
Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene.
[10]
, Benfenati F., Valtorta F., Rubenstein J.L., Gorelick F.S., Greengard P., Czernik A.J.
Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
Camk2a antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of Camk2a antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Camk2a antibody, all related information, articles, resources about Camk2a antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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