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| Gamma-aminobutyric-acid receptor gamma-2 subunit Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-662-20042 |
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| Related Product Names:
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Gabrg2 antibody; Gabrg2; Gamma-aminobutyric-acid receptor gamma-2 subunit
- GABA(A) receptor; Gamma-aminobutyric acid A receptor, gamma 2 [Rattus norvegicus] |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: Gabrg2 |
Gene Name Synonym: N/A |
Gi #:
34328527 |
NCBI Acc #:
NP_899156.1 |
Swiss Prot Acc #:
P18508 |
Length (aa): 466 |
Mol. Weight (Da): 54077 |
Chrom Location: 10q21 |
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 Immunogen: Fusion protein from the Cytosolic Loop of the g2-subunit of rat GABAA Receptor.
Antibody Specificity: Specific for the ~44k to 47k g2-subunit of the GABAA Receptor in Western blots of rat brain extracts. Also recognizes the g2-subunit of the GABAA-R in bovine, human and mouse brain extracts.
Source/Host: Rabbit
Purity/Purification: Affinity Purified
Clonality: Polyclonal
Crossreactivity: Cow, human, mouse
Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.
Stability: 6-12 months at -20 degree C.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for GABRG2 ANTIBODY: |
| WB: Tested |
| ELISA, ICC, IHC: Not Tested |
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| TESTING: (secondary reagents and protocols
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Western Blot: Western Blot of forebrain lysates and the purified GABAA-R. Blots were incubated with anti-GABAA-R, g2-Subunit, C-Terminus diluted 1:1000 overnight at 4°C. The antibody labelled the ~44k to 47k g2-subunit of GABAA -R. ( anti-Gabrg2 )Gabrg2 antibody Western Blot image
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| GABRG2 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for Gabrg2 antibody: Gabrg2; GABA(A) receptor; Gamma-aminobutyric acid A receptor, gamma 2 [Rattus norvegicus]
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular Location: Membrane; multi-pass membrane protein.
Ptm: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity).
Miscellaneous: This subunit carries the benzodiazepine binding site.
Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family [view classification].
Gamma-aminobutyric-acid receptor gamma-2 subunit reacts with cow, human, mouse.
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for GABRG2 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Li,R.W., Yu,W., Christie,S., Miralles,C.P., Bai,J., Loturco,J.J. and De Blas,A.L.
Disruption of postsynaptic GABA receptor clusters leads to decreased GABAergic innervation of pyramidal neurons
[2] Li,X.Q., Dong,L., Liu,Z.H. and Luo,J.Y., et al.
Expression of gamma-aminobutyric acid A receptor subunits alpha1, beta1, gamma2 mRNA in rats with hepatic encephalopathy
[3] Shu,H.J., Eisenman,L.N., Jinadasa,D., Covey,D.F., Zorumski,C.F. and Mennerick,S.
Slow actions of neuroactive steroids at GABAA receptors
[4] Ramakrishnan,L. and Hess,G.P., et al.
On the mechanism of a mutated and abnormally functioning gamma-aminobutyric acid (A) receptor linked to epilepsy
[5] Danglot,L., Triller,A. and Bessis,A., et al.
Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons
[6] , Shivers B.D., Killisch I., Sprengel R., Sontheimer H., Koehler M., Schofield P.R., Seeburg P.H.
Two novel GABAA receptor subunits exist in distinct neuronal subpopulations.
[7] , Malherbe P., Sigel E., Baur R., Persohn E., Richards J.G., Mohler H.
Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: Gabrg2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of Gabrg2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Gabrg2 antibody, all related information, articles, resources about Gabrg2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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