Alphabetical Listing of Primary Antibodies:
f
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
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0-4
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5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
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ELISA Kits
Thyroid hormone receptor alpha Antibody, Mouse Monoclonal Antibody
Catalog Number: 20-662-20100
Buy THRA antibody -
Volume:
0.1 ml ($330.00)
Related Product Names:
- THRA antibody; THRA; ERBA1; NR1A1; THRA1; AR7; EAR7; ERBA; THRA2; THRA3; EAR-7.1; EAR-7.2; ERB-T-1; MGC43240; c-ERBA-1; MGC000261; Thyroid hormone receptor alpha
- C-erbA-alpha; c-erbA-1; EAR-7; EAR7; Thyroid hormone receptor, alpha isoform 2
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
THRA
Gene Name Synonym:
ERBA1; NR1A1; THRA1; AR7; EAR7; ERBA; THRA2; THRA3; EAR-7.1; EAR-7.2; ERB-T-1; MGC43240; c-ERBA-1; MGC000261
Gi #:
20127452
NCBI Acc #:
NP_003241.2
Swiss Prot Acc #:
P10827
Length (aa):
490
Mol. Weight (Da):
54816
Chrom Location:
17q11.2
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a2-isotype.
Clone:
1330
Subclass:
IgG1
Antibody Specificity:
Specific for the ~58k human THR-a2 protein.
Source/Host:
Mouse
Purity/Purification:
Affinity Purified
Clonality:
Monoclonal
Crossreactivity:
Human
Storage:
4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.
Stability:
6-12 months at -20 degree C.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for THRA ANTIBODY:
WB: Tested
ELISA, ICC, IHC: Not Tested
TESTING: (
secondary reagents
and
protocols
)
Western Blot:
Western Blot of brain lysate showing specific immunolabeling of the ~58k hTHR-a2 protein. ( anti-THRA )
THRA antibody Western Blot image
THRA ANTIBODY TARGET DESCRIPTION:
Synonym Names for THRA antibody:
THRA; ERBA1; NR1A1; THRA1; AR7; EAR7; ERBA; THRA2; THRA3; EAR-7.1; EAR-7.2; ERB-T-1; MGC43240; c-ERBA-1; MGC000261; C-erbA-alpha; c-erbA-1; EAR-7; EAR7; Thyroid hormone receptor, alpha isoform 2
Function:
Nuclear hormone receptor. High affinity receptor for triiodothyronine.
Subunit:
Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ (By similarity).
Subcellular Location:
Nucleus.
Domain:
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Similarity:
Contains 1 nuclear receptor DNA-binding domain.
Summary:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Thyroid hormone receptor alpha reacts with human.
OMIM:
190120; gene. [
NCBI
/
EBI
]
Pathways:
KEGG pathway:
Neuroactive ligand-receptor
interaction
04080
Products similar to THRA antibody:
IgG
Bacillus anthracis protective antigen [BAP0102], IgG
THYROID HORMONE RECEPTOR ALPHA 1, IgG
NR2F6 (nuclear receptor subfamily 2. group F. member 6), IgG
NR2F6 (nuclear receptor subfamily 2. group F. member 6), IgG
THRB, IgG
Protein
PDI Human, Protein
HIV-1 p55 gag, Protein
PRODUCT INTERACTIONS:
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for THRA ANTIBODY:
Background references for antibody target are not specific to GenWay products
[1]
Wan,W., Farboud,B. and Privalsky,M.L., et al.
Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function
[2]
Feart,C., Pallet,V., Boucheron,C., Higueret,D., Alfos,S., Letenneur,L., Dartigues,J.F. and Higueret,P.
Aging affects the retinoic acid and the triiodothyronine nuclear receptor mRNA expression in human peripheral blood mononuclear cells
[3]
Nunes,F.M., Aparicio,R., Santos,M.A., Portugal,R.V., Dias,S.M., Neves,F.A., Simeoni,L.A., Baxter,J.D., Webb,P. and Polikarpov,I.
Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain
[4]
DeLong,L.J., Bonamy,G.M., Fink,E.N. and Allison,L.A., et al.
Nuclear export of the oncoprotein v-ErbA is mediated by acquisition of a viral nuclear export sequence
[5]
Sanchez-Pacheco,A. and Aranda,A., et al.
Binding of the thyroid hormone receptor to a negative element in the basal growth hormone promoter is associated with histone acetylation
[6]
, Laudet V., Begue A., Henry C., Joubel A., Martin P., Stehelin D., Saule S.
Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene.
[7]
, Miyajima N., Horiuchi R., Shibuya Y., Fukushige S., Matsubara K., Toyoshima K., Yamamoto T.
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
[8]
, Nakai A., Seino S., Sakurai A., Szilak I., Bell G.I., Degroot L.J.
Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.
[9]
, Pfahl M., Benbrook D.
Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor.
[10]
, Nakai A., Sakurai A., Bell G.I., Degroot L.J.
Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
THRA antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of THRA antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about THRA antibody, all related information, articles, resources about THRA antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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