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| c-Abl (Ab-412) Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-785-210008 |
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| Related Product Names:
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ABL antibody; ABL; ABL; JTK7; c-Abl (Ab-412)
- EC 2.7.10.2; p150; c-ABL; Abelson murine leukemia viral oncogene homolog 1; Proto-oncogene tyrosine-protein kinase ABL1 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: ABL |
Gene Name Synonym: ABL; JTK7 |
Gi #:
N/A |
NCBI Acc #:
N/A |
Swiss Prot Acc #:
P00519 |
Length (aa): N/A |
Mol. Weight (Da): 122873 |
Chrom Location: N/A |
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 Binding Site: around Tyr412
WB Dilution: 500~1000
IHC Dilution: 50~100
Source/Host: Rabbit
Purity/Purification: Affinity Purified
Clonality: Polyclonal
Crossreactivity: Human, Mouse
Format: Phosphate buffered saline (without Mg2+ and Ca), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Quality Control: The quality of the peptide was evaluated by revesered-phase HPLC and mass spectrometry
Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.
Stability: 1 year at -20C
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for ABL ANTIBODY: |
| IHC: Tested |
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| ABL ANTIBODY TARGET DESCRIPTION: |
Synonym Names for ABL antibody: ABL; ABL; JTK7; EC 2.7.10.2; p150; c-ABL; Abelson murine leukemia viral oncogene homolog 1; Proto-oncogene tyrosine-protein kinase ABL1
Function: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Cofactor: Magnesium or manganese.
Enzyme Regulation: Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML).
Subunit: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity).
Subcellular Location: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
Tissue Specificity: Widely expressed.
Ptm: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.
Disease: A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
Similarity: Contains 1 protein kinase domain.
Similarity: Contains 1 SH2 domain.
Similarity: Contains 1 SH3 domain.
c-Abl (Ab-412) reacts with human, mouse.
OMIM: 189980; gene. [NCBI / EBI]
608232; phenotype. [NCBI / EBI]
Pathways:
KEGG pathway: Axon guidance 04360
KEGG pathway: Cell cycle 04110
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: ErbB signaling pathway 04012
KEGG pathway: Pathogenic Escherichia coli infection - EHEC 05130
KEGG pathway: Pathogenic Escherichia coli infection - EPEC 05131
Products similar to ABL antibody:
IgG
 c-Abl phospho Y245, IgG
Mouse Anti-Human SMAC/DIABLO, IgG
Diablo homolog, mitochondrial, IgG
DIABLO (diablo homolog (Drosophila)), IgG
c-Abl (Phospho-Tyr412), IgG
Peptide
c-Abl (Phospho-Tyr412) Antibody Blocking Peptide, Peptide
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| PRODUCT INTERACTIONS: |
c-Abl (Ab-412) interacts with Spectrin Binding Protein, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [2C1], IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [2C1], IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [3E8], IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [3E8], IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [5C2], IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [5C2], IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ataxia telangiectasia mutated (includes complementation groups A, C and D) (ATM), transcript variant 1, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM (Phospho-Ser1981) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM phospho S1981, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [2C1] (supernatant), IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM phospho S1981, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM [ATX08], IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM, IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with ATM Phospho (pS1981), IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with 14-3-3 protein sigma, Protein (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with Recombinant Human Tyr-3/Trp- 5 Monooxygenase Activation Protein, Sigma, Protein (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with 14-3-3 protein zeta/delta, Protein (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with 14-3-3 zeta (Phospho-Ser58), IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with 14-3-3 zeta (Ab-58), IgG (GenWay Catalog #: 18-785-210008).
c-Abl (Ab-412) interacts with Recombinant Human Tyr- 3/Trp-5 Mmonooxygenase Activation protein, Zeta, Protein (GenWay Catalog #: 18-785-210008).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for ABL ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Fainstein E., Einat M., Gokkel E., Marcelle C., Croce C.M., Gale R.P., Canaani E.
Nucleotide sequence analysis of human abl and bcr-abl cDNAs.
[2] Shtivelman E., Lifshitz B., Gale R.P., Roe B.A., Canaani E.
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
[3] Chissoe S.L., Bodenteich A., Wang Y.-F., Wang Y.-P., Burian D., Clifton S.W., Crabtree J., Freeman A., Iyer K., Jian L., et al.
Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
[4] Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., et al.
NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).
[5] Fainstein E., Marcelle C., Rosner A., Canaani E., Gale R.P., Dreazen O., Smith S.D., Croce C.M.
A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.
[6] Groffen J., Heisterkamp N., Reynolds F.H. Jr., Stephenson J.R.
Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.
[7] Inokuchi K., Futaki M., Dan K., Nomura T.
Sequence analysis of the mutation at codon 834 and the sequence variation of codon 837 of c-abl gene.
[8] Jackson P., Baltimore D.
N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.
[9] Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T., Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., et al.
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
[10] Lin W.-H., Huang C.-J., Liu M.-W., Chang H.-M., Chen Y.-J., Tai T.-Y., Chuang L.-M.
Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: ABL antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of ABL antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ABL antibody, all related information, articles, resources about ABL antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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