ATF-4 antibody, ATF4 (Ab-245) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

ATF4 (Ab-245) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-785-210034

Buy ATF-4 antibody -

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Related Product Names:

- ATF-4 antibody; ATF-4; TXREB; ATF4 (Ab-245)
- Activating transcription factor 4; DNA-binding protein TAXREB67; Cyclic AMP response element-binding protein 2; CREB2; Cyclic AMP-dependent transcription factor ATF-4

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ATF-4	Gene Name Synonym: TXREB
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: P18848
Length (aa): N/A	Mol. Weight (Da): 38590	Chrom Location: N/A

Binding Site: around Ser245

WB Dilution: 500~1000

IHC Dilution: 50~100

Source/Host: Rabbit

Purity/Purification: Affinity Purified

Clonality: Polyclonal

Crossreactivity: Human

Format: In PBS, 0.02% sodium azide and 50% glycerol.

Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.

Stability: 1 year at -20C

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ATF-4 ANTIBODY:

IHC: Tested

TESTING: (secondary reagents and protocols )

IHC ( anti-ATF-4 )

ATF-4 antibody image
ATF-4

ATF-4 ANTIBODY TARGET DESCRIPTION:

Synonym Names for ATF-4 antibody: ATF-4; TXREB; Activating transcription factor 4; DNA-binding protein TAXREB67; Cyclic AMP response element-binding protein 2; CREB2; Cyclic AMP-dependent transcription factor ATF-4

Function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.

Subunit: Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo- or heterodimer. Interacts with the N-terminal region of CEP290.

Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity).

Similarity: Belongs to the bZIP family.

Similarity: Contains 1 bZIP domain.

ATF4 (Ab-245) reacts with human.

OMIM: 604064; gene. [NCBI / EBI]

Pathways:
KEGG pathway: GnRH signaling pathway 04912
KEGG pathway: Long-term potentiation 04720
KEGG pathway: MAPK signaling pathway 04010
KEGG pathway: Prostate cancer 05215

Products similar to ATF-4 antibody:

IgG

ATF4, IgG

ATF4 (Phospho-Ser245), IgG

ATF4, IgG

ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)), IgG

ATF4 (Phospho-Ser245) Antibody Blocking Peptide, Peptide

PRODUCT INTERACTIONS:

ATF4 (Ab-245) interacts with C/EBP-beta (clone 47A1), IgG (GenWay Catalog #: 18-785-210034).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for ATF-4 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Tsujimoto A., Nyunoya H., Morita T., Sato T., Shimotohno K.
     Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.
[2] Karpinski B.A., Morle G.D., Huggenvik J., Uhler M.D., Leiden J.M.
     Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
[3] Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., et al.
     The DNA sequence of human chromosome 22.
[4] Hai T., Liu F., Coukos W.J., Green M.R.
     Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.
[5] Hai T., Liu F., Coukos W.J., Green M.R.
     Genes Dev. 4:682-682(1990).
[6] Sayer J.A., Otto E.A., O'toole J.F., Nurnberg G., Kennedy M.A., Becker C., Hennies H.C., Helou J., Attanasio M., Fausett B.V., et al.
     The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.
[7] Podust L.M., Krezel A.M., Kim Y.
     Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ATF-4 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ATF-4 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ATF-4 antibody, all related information, articles, resources about ATF-4 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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