BCL-XL antibody, BCL-XL (Ab-62) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

BCL-XL (Ab-62) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-785-210052

Buy BCL-XL antibody -

Size:

Related Product Names:

- BCL-XL antibody; BCL-XL; BCL2L; BCLX; BCL-XL (Ab-62)
- Bcl-2-like 1 protein; Apoptosis regulator Bcl-X

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: BCL-XL	Gene Name Synonym: BCL2L; BCLX
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: Q07817
Length (aa): N/A	Mol. Weight (Da): 26049	Chrom Location: N/A

Binding Site: around Ser62

WB Dilution: 500~1000

IHC Dilution: 50~100

Source/Host: Rabbit

Purity/Purification: Affinity Purified

Clonality: Polyclonal

Crossreactivity: Human, Mouse, Rat

Format: In PBS, 0.02% sodium azide and 50% glycerol.

Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.

Stability: 1 year at -20C

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for BCL-XL ANTIBODY:

IHC, WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-BCL-XL )

BCL-XL antibody tern B image
BCL-XL

IHC ( anti-BCL-XL )

BCL-XL antibody image
BCL-XL

BCL-XL ANTIBODY TARGET DESCRIPTION:

Synonym Names for BCL-XL antibody: BCL-XL; BCL2L; BCLX; Bcl-2-like 1 protein; Apoptosis regulator Bcl-X

Function: Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

Subunit: Bcl-X(L) forms heterodimers with BAX, BAK and Bcl-2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Also interacts with BBC3. Isoform Bcl-X(L) binds to Siva isoform 1 (By similarity). Interacts with PGAM5.

Subcellular Location: Mitochondrion membrane; Single-pass membrane protein (By similarity). Nucleus envelope; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=Mitochondrial membranes and perinuclear envelope (By similarity).

Tissue Specificity: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Domain: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.

Ptm: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.

Similarity: Belongs to the Bcl-2 family.

BCL-XL (Ab-62) reacts with human, mouse, rat.

OMIM: 600039; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Amyotrophic lateral sclerosis (ALS) 05030
KEGG pathway: Apoptosis 04210
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: Jak-STAT signaling pathway 04630
KEGG pathway: Neurodegenerative Disorders 01510
KEGG pathway: Pancreatic cancer 05212
KEGG pathway: Small cell lung cancer 05222
Reactome Event:Apoptosis 109581

Products similar to BCL-XL antibody:

IgG

Bak, IgG

Bcl-X [SPM165], IgG

BCL 2L2 [90316.11], IgG

BIM (AD/ACD/ABCD isoforms), IgG

Bak, IgG

Peptide

BAD (Phospho-Ser112) Antibody Blocking Peptide, Peptide

BIM(Phospho-Ser69/65) Antibody Blocking Peptide, Peptide

BCL-XL (Phospho-Ser62) Antibody Blocking Peptide, Peptide

BAD (Phospho-Ser155) Antibody Blocking Peptide, Peptide

BAD Protein Human, Protein

PRODUCT INTERACTIONS:

BCL-XL (Ab-62) interacts with Bcl2 antagonist of cell death, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD (Phospho-Ser112), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD (Phospho-Ser155), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD (Ab-112), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD (Ab-136), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD (Ab-155), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD (Phospho-Ser112) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD (Phospho-Ser155) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAD Protein Human, Protein (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bad phospho S112 antibody, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bad phospho S128, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bad phospho S112, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bad [64103], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bcl-2 homologous antagonist/killer, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAK1, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bak, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bak [TC100], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bak, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bak (ready-to-use), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Apoptosis regulator BAX, membrane isoform alpha, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAX (BCL2-associated X protein), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAX, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Human Bax, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with beta Bax, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Apoptosis regulator BAX, membrane isoform alpha, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAX (BCL2-associated X protein), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAX, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Human Bax, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with beta Bax, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bcl-2-binding component 3, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with PUMA ALPHA, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Rabbit anti PUMA, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bcl-2-binding component 3, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with PUMA ALPHA, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Rabbit anti PUMA, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAP31, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BAP31 [CC-4], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Rabbit anti BAP31, C-term, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bcl-2-like protein 11, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BIM, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BIM (Phospho-Ser65), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BIM (Ab-65), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BIM(Phospho-Ser69/65) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bim (ready-to-use), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bim, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BH3-interacting domain death agonist, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bid, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Mouse Anti-Human Bid, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BID, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bid, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BH3-interacting domain death agonist, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bid, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Mouse Anti-Human Bid, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BID, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Bid, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with BIK, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with HRK, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Rabbit anti Harakiri (Hrk), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with HRK, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Rabbit anti Harakiri (Hrk), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with NALP1 [Nalpy1-4], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Rabbit anti NALP1, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with DEFCAP, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Cellular tumor antigen p53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 Human, Protein (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53M Human, Protein (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [SP5], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 phospho S15, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [DO-13], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [DO-7], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [Pab240], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [D01], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [3F301], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [DO-7] (ready-to-use), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [BP53-12], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with I-kappaB-alpha (Phospho-Ser32/Ser36), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Phospho-Ser15), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Phospho-Ser46), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Phospho-Ser315), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Ab-15), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Ab-46), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Ab-315), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Phospho-Ser15) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Phospho-Ser46) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (Phospho-Ser315) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with TP53 (tumor protein p53 (Li-Fraumeni syndrome)), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (a.a. 32-79), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (a.a. 88-109), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 (a.a. 306-393), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Mouse p53, Wild Type, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Human p53 Oncogene, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [B20.1 (BP 53.122)] antibody (ready-to-use), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 AIP1, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [BP53-12] (FITC), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [DO-2], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [DO-1], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with P53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [B20.1 (BP 53.122)] antibody (FITC), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with P53 [SP5] (ready-to-use), IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [DO-1], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [B449], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [Pab240], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [Pab1801], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [D01], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53 [DO-2], IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with p53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with TRP53, IgG (GenWay Catalog #: 18-785-210052).

BCL-XL (Ab-62) interacts with Anti p53, IgG (GenWay Catalog #: 18-785-210052).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for BCL-XL ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Boise L.H., Gonzalez-Garcia M., Postema C.E., Ding L., Lindsten T., Turka L.A., Mao X., Nunez G., Thompson C.B.
     bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
[2] Inohara N., Ohta S.
     Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
[3] Ban J., Eckhart L., Weninger W., Mildner M., Tschachler E.
     Identification of a human cDNA encoding a novel Bcl-x isoform.
[4] Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., et al.
     Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
[5] Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., et al.
     The DNA sequence and comparative analysis of human chromosome 20.
[6] Sedlak T.W., Oltvai Z.N., Yang E., Wang K., Boise L.H., Thompson C.B., Korsmeyer S.J.
     Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
[7] Cheng E.H.-Y., Levine B., Boise L.H., Thompson C.B., Hardwick J.M., Korsmeyer S.J.
     Bax-independent inhibition of apoptosis by Bcl-XL.
[8] Yu J., Zhang L., Hwang P.M., Kinzler K.W., Vogelstein B.
     PUMA induces the rapid apoptosis of colorectal cancer cells.
[9] Xue L., Chu F., Cheng Y., Sun X., Borthakur A., Ramarao M., Pandey P., Wu M., Schlossman S.F., Prasad K.V.S., et al.
     Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.
[10] Lo S.-C., Hannink M.
     PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: BCL-XL antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of BCL-XL antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about BCL-XL antibody, all related information, articles, resources about BCL-XL antibody are being stored on our online database. Let us know if you have questions regarding this product.

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