FAK antibody, FAK (Ab-925) Antibody, Rabbit Polyclonal Antibody

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FAK (Ab-925) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-785-210161

Buy FAK antibody -

Size:

Related Product Names:

- FAK antibody; FAK; FAK; FAK1; FAK (Ab-925)
- EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2; Focal adhesion kinase 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FAK	Gene Name Synonym: FAK; FAK1
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: Q05397
Length (aa): N/A	Mol. Weight (Da): 119233	Chrom Location: N/A

Binding Site: around Tyr925

WB Dilution: 500~1000

IHC Dilution: 50~100

Source/Host: Rabbit

Purity/Purification: Affinity Purified

Clonality: Polyclonal

Crossreactivity: Human, Mouse, Rat

Format: In PBS, 0.02% sodium azide and 50% glycerol.

Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.

Stability: 1 year at -20C

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FAK ANTIBODY:

IHC, WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-FAK )

FAK antibody tern B image
FAK

IHC ( anti-FAK )

FAK antibody image
FAK

FAK ANTIBODY TARGET DESCRIPTION:

Synonym Names for FAK antibody: FAK; FAK; FAK1; EC 2.7.10.2; FADK 1; pp125FAK; Protein-tyrosine kinase 2; Focal adhesion kinase 1

Function: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with SHB (By similarity). Interacts with TGFB1I1.

Subcellular Location: Cell junction, focal adhesion; Cytoplasmic side. Note=Constituent of focal adhesions.

Tissue Specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.

Domain: The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL (By similarity).

Domain: The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions.

Ptm: Phosphorylated on 6 tyrosine residues upon activation.

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.

Similarity: Contains 1 FERM domain.

Similarity: Contains 1 protein kinase domain.

FAK (Ab-925) reacts with human, mouse, rat.

OMIM: 600758; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Axon guidance 04360
KEGG pathway: ErbB signaling pathway 04012
KEGG pathway: Focal adhesion 04510
KEGG pathway: Leukocyte transendothelial migration 04670
KEGG pathway: Regulation of actin cytoskeleton 04810
KEGG pathway: Small cell lung cancer 05222
KEGG pathway: VEGF signaling pathway 04370

Products similar to FAK antibody:

IgG

PYK2 phospho Y402, IgG

FAK phospho S732, IgG

FOCAL ADHESION KINASE, IgG

PTK2B (PTK2B protein tyrosine kinase 2 beta), IgG

Pyk2 (Phospho-Tyr402), IgG

Peptide

FAK (Phospho-Tyr925) Antibody Blocking Peptide, Peptide

FAK (Phospho-Tyr861) Antibody Blocking Peptide, Peptide

Pyk2 (Phospho-Tyr402) Antibody Blocking Peptide, Peptide

FAK1 Human, Protein

PRODUCT INTERACTIONS:

FAK (Ab-925) interacts with SRC, Protein (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with SRC, IgG (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with SRC phospho Y529, IgG (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with Src (Phospho-Tyr418), IgG (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with Src (Phospho-Tyr529), IgG (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with Src (Ab-418), IgG (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with Src (Ab-529), IgG (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with Src(Phospho-Tyr418) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with Src (Phospho-Tyr529) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with Src Mouse, Protein (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with SRC, IgG (GenWay Catalog #: 18-785-210161).

FAK (Ab-925) interacts with SRC phospho Y418, IgG (GenWay Catalog #: 18-785-210161).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for FAK ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Whitney G.S., Chan P.Y., Blake J., Cosand W.L., Neubauer M.G., Aruffo A., Kanner S.B.
     Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
[2] Andre E., Becker-Andre M.
     Expression of an N-terminally truncated form of human focal adhesion kinase in brain.
[3] Lee S.-T., Strunk K.M., Spritz R.A.
     A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.
[4] Matsuya M., Sasaki H., Aoto H., Mitaka T., Nagura K., Ohba T., Ishino M., Takahashi S., Suzuki R., Sasaki T., et al.
     Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.
[5] Fujita H., Kamiguchi K., Cho D., Shibanuma M., Morimoto C., Tachibana K.
     Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.
[6] Relou I.A.M., Bax L.A.B., Van Rijn H.J.M., Akkerman J.-W.N.
     Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein.
[7] Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M.
     Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
[8] Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
     Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
[9] Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H.
     Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: FAK antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FAK antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FAK antibody, all related information, articles, resources about FAK antibody are being stored on our online database. Let us know if you have questions regarding this product.

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