IGF1R antibody, IGF-1R (Phospho-Tyr1161) Antibody, Rabbit Polyclonal Antibody

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IGF-1R (Phospho-Tyr1161) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-785-210214

Buy IGF1R antibody -

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Related Product Names:

- IGF1R antibody; IGF1R; IGF-1R (Phospho-Tyr1161)
- EC 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: IGF1R	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: P08069
Length (aa): N/A	Mol. Weight (Da): 154793	Chrom Location: N/A

Binding Site: Tyr1161

WB Dilution: 500~1000

IHC Dilution: 50~100

Source/Host: Rabbit

Purity/Purification: Affinity Purified

Clonality: Polyclonal

Crossreactivity: Human, Mouse, Rat

Format: In PBS, 0.02% sodium azide and 50% glycerol.

Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.

Stability: 1 year at -20C

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for IGF1R ANTIBODY:

IHC, WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-IGF1R )

IGF1R antibody tern B image
IGF1R

IHC ( anti-IGF1R )

IGF1R antibody image
IGF1R

IGF1R ANTIBODY TARGET DESCRIPTION:

Synonym Names for IGF1R antibody: IGF1R; EC 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor

Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.

Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme Regulation: Autophosphorylation activates the kinase activity.

Subunit: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Tissue Specificity: Expressed in a variety of tissues.

Ptm: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).

Ptm: Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Similarity: Contains 3 fibronectin type-III domains.

Similarity: Contains 1 protein kinase domain.

IGF-1R (Phospho-Tyr1161) reacts with human, mouse, rat.

OMIM: 147370; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Adherens junction 04520
KEGG pathway: Colorectal cancer 05210
KEGG pathway: Focal adhesion 04510
KEGG pathway: Glioma 05214
KEGG pathway: Long-term depression 04730
KEGG pathway: Melanoma 05218
KEGG pathway: Prostate cancer 05215

Products similar to IGF1R antibody:

IgG

IGF1 receptor, IgG

IGF1 receptor [alphaIR3], IgG

PRODUCT INTERACTIONS:

IGF-1R (Phospho-Tyr1161) interacts with 14-3-3 Gamma Human, Protein (GenWay Catalog #: 18-785-210214).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for IGF1R ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Ullrich A., Gray A., Tam A.W., Yang-Feng T., Tsubokawa M., Collins C., Henzel W., Bon T.L., Kathuria S., Chen E., et al.
     Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
[2] Abbot A.M., Bueno R., Pedrini M.T., Murray J.M., Smith R.J.
     Insulin-like growth factor I receptor gene structure.
[3] Rieder M.J., Livingston R.J., Daniels M.R., Montoya M.A., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., et al.
     NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).
[4] Cooke D.W., Bankert L.A., Roberts C.T. Jr., Leroith D., Casella S.J.
     Analysis of the human type I insulin-like growth factor receptor promoter region.
[5] Lee S.-T., Strunk K.M., Spritz R.A.
     A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.
[6] Tollefsen S.E., Stoszek R.M., Thompson K.
     Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation.
[7] Kato H., Faria T.N., Stannard B., Roberts C.T. Jr., LeRoith D.
     Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).
[8] Craparo A., O'Neill T.J., Gustafson T.A.
     Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
[9] Lopaczynski W., Terry C., Nissley P.
     Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: IGF1R antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of IGF1R antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about IGF1R antibody, all related information, articles, resources about IGF1R antibody are being stored on our online database. Let us know if you have questions regarding this product.

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