Alphabetical Listing of Primary Antibodies:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
|
P
|
Q
|
R
|
S
|
T
|
U
|
V
|
W
|
X
|
Y
|
Z
|
Alphabetical Listing of Proteins:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
|
P
|
Q
|
R
|
S
|
T
|
U
|
V
|
W
|
X
|
Y
|
Z
|
Peptides
|
Secondary Antibodies
|
ELISA Kits
Integrin -beta3 (Phospho-Tyr773) Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-785-210224
Buy INTEGRIN B3 antibody -
Size:
0.05 mg ($225.00)
0.1 mg ($315.00)
Related Product Names:
- INTEGRIN B3 antibody; INTEGRIN B3; GP3A; Integrin -beta3 (Phospho-Tyr773)
- Platelet membrane glycoprotein IIIa; GPIIIa; CD61 antigen; Integrin beta-3
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
INTEGRIN B3
Gene Name Synonym:
GP3A
Gi #:
N/A
NCBI Acc #:
N/A
Swiss Prot Acc #:
P05106
Length (aa):
N/A
Mol. Weight (Da):
87058
Chrom Location:
N/A
Binding Site:
Tyr773
WB Dilution:
500~1000
IHC Dilution:
50~100
Source/Host:
Rabbit
Purity/Purification:
Affinity Purified
Clonality:
Polyclonal
Crossreactivity:
Human, Mouse
Format:
In PBS, 0.02% sodium azide and 50% glycerol.
Storage:
4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.
Stability:
1 year at -20C
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for INTEGRIN B3 ANTIBODY:
IHC, WB: Tested
TESTING: (
secondary reagents
and
protocols
)
Western Blot ( anti-INTEGRIN B3 )
INTEGRIN B3 antibody tern B image
IHC ( anti-INTEGRIN B3 )
INTEGRIN B3 antibody image
INTEGRIN B3 ANTIBODY TARGET DESCRIPTION:
Synonym Names for INTEGRIN B3 antibody:
INTEGRIN B3; GP3A; Platelet membrane glycoprotein IIIa; GPIIIa; CD61 antigen; Integrin beta-3
Function:
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Subunit:
Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with HIV-1 Tat.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Ptm:
Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. SHC binding also occurs when Tyr-785 alone is phosphorylated.
Polymorphism:
Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)). HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59.
Polymorphism:
Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP).
Polymorphism:
Position 433 is associated with platelet-specific alloantigen MO. MO(-) has Pro-433 and MO(+) has Ala-433. MO(+) is involved in NAIT.
Polymorphism:
Position 515 is associated with platelet-specific alloantigen CA/TU. CA(-)/TU(-) has Arg-515 and CA(+)/TU(+) has Gln-515. CA(+) is involved in NAIT.
Polymorphism:
Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)(-) has Arg-662 and SR(A)(+) has Cys-662.
Disease:
Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.
Similarity:
Belongs to the integrin beta chain family.
Similarity:
Contains 1 VWFA domain.
Integrin -beta3 (Phospho-Tyr773) reacts with human, mouse.
OMIM:
173470; gene+phenotype. [
NCBI
/
EBI
]
273800; phenotype. [
NCBI
/
EBI
]
Pathways:
KEGG pathway: ECM-receptor interaction
04512
KEGG pathway:
Focal adhesion
04510
KEGG pathway:
Hematopoietic
cell lineage
04640
KEGG pathway: Regulation of actin cytoskeleton
04810
Reactome Event:Hemostasis
109582
Products similar to INTEGRIN B3 antibody:
IgG
CD61, IgG
CD61, IgG
CD61, IgG
CD61, IgG
Rat CD61 gp IIIa, IgG
Peptide
Integrin -beta3 (Phospho-Tyr773) Antibody Blocking Peptide, Peptide
PRODUCT INTERACTIONS:
Integrin -beta3 (Phospho-Tyr773)
interacts
with
WNV Envelope, Protein
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/CD61, IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/61 [23C6], IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
Integrin alpha V [23C6], IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
Integrin alpha V beta 3 [23C6], IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/CD61, IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/CD61, IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51, IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/CD61, IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/61, IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
Integrin alpha V [P2W7], IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/CD61, IgG
(GenWay Catalog #: 18-785-210224)
.
Integrin -beta3 (Phospho-Tyr773)
interacts
with
CD51/CD61, IgG
(GenWay Catalog #: 18-785-210224)
.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for INTEGRIN B3 ANTIBODY:
Background references for antibody target are not specific to GenWay products
[1]
Fitzgerald L.A., Steiner B., Rall S.C. Jr., Lo S., Phillips D.R.
Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'.
[2]
Zimrin A.B., Eisman R., Vilaire G., Schwartz E., Bennett J.S., Poncz M.
Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.
[3]
Frachet P., Uzan G., Thevenon D., Denarier E., Prandini M.H., Marguerie G.
GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs.
[4]
Kumar C.S., James I.E., Wong A., Mwangi V., Feild J.A., Nuthulaganti P., Connor J.R., Eichman C., Ali F., Hwang S.M., et al.
Cloning and characterization of a novel integrin beta3 subunit.
[5]
Villa-Garcia M., Li L., Riely G., Bray P.F.
Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene.
[6]
Rosa J.P., Bray P.F., Gayet O., Johnston G.I., Cook R.G., Jackson K.W., Shuman M.A., McEver R.P.
Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17.
[7]
Catimel B., Parmentier S., Leung L.L., McGregor J.L.
Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing.
[8]
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
[9]
Zimrin A.B., Gidwitz S., Lord S., Schwartz E., Bennett J.S., White G.C. II, Poncz M.
The genomic organization of platelet glycoprotein IIIa.
[10]
Lanza F., Kieffer N., Phillips D.R., Fitzgerald L.A.
Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
INTEGRIN B3 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of INTEGRIN B3 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about INTEGRIN B3 antibody, all related information, articles, resources about INTEGRIN B3 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.
Exact |
Advanced Search
Specific Categories
Antibodies
Secondary Antibodies
Proteins
Custom Antibody
ELISA Kits
Reagents
Products by Pathway
Protein Expression
Cell Line Development
GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121
Tel:
(858)458-0866
Fax:
(858)458-0833
Email:
sales@genwaybio.com
www.genwaybio.com
©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved
