MEK-2 antibody, MEK-2 (Phospho-Thr394) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

MEK-2 (Phospho-Thr394) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-785-210273

Buy MEK-2 antibody -

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Related Product Names:

- MEK-2 antibody; MEK-2; MEK2; MKK2; PRKMK2; MEK-2 (Phospho-Thr394)
- EC 2.7.12.2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK2; Dual specificity mitogen-activated protein kinase kinase 2

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: MEK-2	Gene Name Synonym: MEK2; MKK2; PRKMK2
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: P36507
Length (aa): N/A	Mol. Weight (Da): 44424	Chrom Location: N/A

Binding Site: Thr394

WB Dilution: 500~1000

IHC Dilution: 50~100

Source/Host: Rabbit

Purity/Purification: Affinity Purified

Clonality: Polyclonal

Crossreactivity: Human, Mouse, Rat

Format: In PBS, 0.02% sodium azide and 50% glycerol.

Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.

Stability: 1 year at -20C

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for MEK-2 ANTIBODY:

IHC, WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-MEK-2 )

MEK-2 antibody tern B image
MEK-2

IHC ( anti-MEK-2 )

MEK-2 antibody image
MEK-2

MEK-2 ANTIBODY TARGET DESCRIPTION:

Synonym Names for MEK-2 antibody: MEK-2; MEK2; MKK2; PRKMK2; EC 2.7.12.2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK2; Dual specificity mitogen-activated protein kinase kinase 2

Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

Catalytic Activity: ATP + a protein = ADP + a phosphoprotein.

Subunit: Interacts with MORG1 (By similarity).

Ptm: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Similarity: Contains 1 protein kinase domain.

MEK-2 (Phospho-Thr394) reacts with human, mouse, rat.

OMIM: 601263; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: Endometrial cancer 05213
KEGG pathway: ErbB signaling pathway 04012
KEGG pathway: Fc epsilon RI signaling pathway 04664
KEGG pathway: Gap junction 04540
KEGG pathway: Glioma 05214
KEGG pathway: GnRH signaling pathway 04912
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: Long-term depression 04730
KEGG pathway: Long-term potentiation 04720
KEGG pathway: MAPK signaling pathway 04010
KEGG pathway: Melanogenesis 04916
KEGG pathway: Melanoma 05218
KEGG pathway: Natural killer cell mediated cytotoxicity 04650
KEGG pathway: Non-small cell lung cancer 05223
KEGG pathway: Prostate cancer 05215
KEGG pathway: Regulation of actin cytoskeleton 04810
KEGG pathway: Renal cell carcinoma 05211
KEGG pathway: Thyroid cancer 05216
KEGG pathway: VEGF signaling pathway 04370

Products similar to MEK-2 antibody:

IgG

MEK2 phospho T394, IgG

MEK1 + MEK2 phospho S222, IgG

MEK-2 (Ab-394), IgG

MEK-2 (Phospho-Thr394) Antibody Blocking Peptide, Peptide

PRODUCT INTERACTIONS:

MEK-2 (Phospho-Thr394) interacts with ARAF, IgG (GenWay Catalog #: 18-785-210273).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for MEK-2 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Zheng C.-F., Guan K.-L.
     Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
[2] Duesbery N.S., Webb C.P., Leppla S.H., Gordon V.M., Klimpel K.R., Copeland T.D., Ahn N.G., Oskarsson M.K., Fukasawa K., Paull K.D., et al.
     Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.
[3] Vitale G., Bernardi L., Napolitani G., Mock M., Montecucco C.
     Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.
[4] Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
     Large-scale characterization of HeLa cell nuclear phosphoproteins.
[5] Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
     Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
[6] Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
     A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
[7] Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H.
     Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: MEK-2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of MEK-2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MEK-2 antibody, all related information, articles, resources about MEK-2 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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