p70S6k antibody, p70 S6 Kinase (Ab-411) Antibody, Rabbit Polyclonal Antibody

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p70 S6 Kinase (Ab-411) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-785-210342

Buy p70S6k antibody -

Size:

Related Product Names:

- p70S6k antibody; p70S6k; STK14A; p70 S6 Kinase (Ab-411)
- EC 2.7.11.1; Ribosomal protein S6 kinase I; S6K; S6K1; 70 kDa ribosomal protein S6 kinase 1; p70 S6 kinase alpha; p70(S6K)-alpha; p70-S6K; P70S6K; p70-alpha; Ribosomal protein S6 kinase beta-1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: p70S6k	Gene Name Synonym: STK14A
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: P23443
Length (aa): N/A	Mol. Weight (Da): 59140	Chrom Location: N/A

Binding Site: around Ser411

WB Dilution: 500~1000

IHC Dilution: 50~100

Storage/Stability: Sore at -20C/1 year

Form of Antibody: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human p70 S6 Kinase around the phosphorylation site of serine 411 (I-R-SP-P-R).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity: p70 S6 Kinase (Ab-411) antibody detects endogenous levels of total p70 S6 Kinase protein.

Applications: WB: 1:500~1:1000 IHC: 1:50-1:100 IF:1:100~1:200

Source/Host: Rabbit

Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Clonality: Polyclonal

Crossreactivity: Human, Mouse, Rat

Format: In PBS, 0.02% sodium azide and 50% glycerol.

Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.

Stability: 1 year at -20C

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for P70S6K ANTIBODY:

IHC, WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-p70S6k )

p70S6k antibody tern B image
p70S6k

IHC ( anti-p70S6k )

p70S6k antibody image
p70S6k

P70S6K ANTIBODY TARGET DESCRIPTION:

Synonym Names for p70S6k antibody: p70S6k; STK14A; EC 2.7.11.1; Ribosomal protein S6 kinase I; S6K; S6K1; 70 kDa ribosomal protein S6 kinase 1; p70 S6 kinase alpha; p70(S6K)-alpha; p70-S6K; P70S6K; p70-alpha; Ribosomal protein S6 kinase beta-1

Function: Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.

Catalytic Activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme Regulation: Activation by serine/threonine phosphorylation and protein kinase C, inactivated by type 2A phosphatase.

Subunit: Interacts with PPP1R9A/neurabin-1 (By similarity).

Subcellular Location: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).

Tissue Specificity: Widely expressed.

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

Similarity: Contains 1 AGC-kinase C-terminal domain.

Similarity: Contains 1 protein kinase domain.

p70 S6 Kinase (Ab-411) reacts with human, mouse, rat.

OMIM: 608938; gene. [NCBI / EBI]

Pathways:
KEGG pathway: ErbB signaling pathway 04012
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: TGF-beta signaling pathway 04350
KEGG pathway: mTOR signaling pathway 04150
Reactome Event:Signaling by insulin receptor 74752

Products similar to p70S6k antibody:

IgG

p70 S6 Kinase (Ab-421), IgG

p70 S6 Kinase (Phospho-Ser411), IgG

S6K phospho T229, IgG

p70S6K / RPS6KB1, IgG

p70 S6 Kinase (Ab-389), IgG

Peptide

p70 S6 Kinase (Phospho-Thr421) Antibody Blocking Peptide, Peptide

p70 S6 Kinase (Phospho-Ser424) Antibody Blocking Peptide, Peptide

p70 S6 Kinase Phospho-Ser411) Antibody Blocking Peptide, Peptide

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for P70S6K ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Grove J., Bonerjee P., Balasubramanyam A., Coffer P., Price D.J., Avruch J., Woodgett J.R.
     Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.
[2] Gout I., Minami T., Hara K., Tsujishita Y., Filonenko V., Waterfield M.D., Yonezawa K.
     Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.
[3] Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
     Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
[4] Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
     A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: p70S6k antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of p70S6k antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about p70S6k antibody, all related information, articles, resources about p70S6k antibody are being stored on our online database. Let us know if you have questions regarding this product.

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