|
|
| SHP-2 (Phospho-Tyr542) Antibody, Rabbit Polyclonal Antibody |
 |
|
|
 |
| Catalog Number: 18-785-210412 |
|
|
|
| Related Product Names:
|
-
SHP-2 antibody; SHP-2; PTP2C; SHPTP2; SHP-2 (Phospho-Tyr542)
- EC 3.1.3.48; Protein-tyrosine phosphatase 2C; PTP-2C; PTP-1D; SH-PTP3; SH-PTP2; SHP-2; Shp2; Tyrosine-protein phosphatase non-receptor type 11 |
|
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
|
|
| Gene Name: SHP-2 |
Gene Name Synonym: PTP2C; SHPTP2 |
Gi #:
N/A |
NCBI Acc #:
N/A |
Swiss Prot Acc #:
Q06124 |
Length (aa): N/A |
Mol. Weight (Da): 68436 |
Chrom Location: N/A |
|
|
 Binding Site: Tyr542
WB Dilution: 500~1000
IHC Dilution: 50~100
Source/Host: Rabbit
Purity/Purification: Affinity Purified
Clonality: Polyclonal
Crossreactivity: Human, Mouse, Rat
Format: In PBS, 0.02% sodium azide and 50% glycerol.
Storage: 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.
Stability: 1 year at -20C
Shipping: Products may be shipped on ice pack or dry ice. |
|
| APPLICATIONS for SHP-2 ANTIBODY: |
| IHC: Tested |
|
|
|
|
| SHP-2 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for SHP-2 antibody: SHP-2; PTP2C; SHPTP2; EC 3.1.3.48; Protein-tyrosine phosphatase 2C; PTP-2C; PTP-1D; SH-PTP3; SH-PTP2; SHP-2; Shp2; Tyrosine-protein phosphatase non-receptor type 11
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
Catalytic Activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB (By similarity). Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL6.
Subcellular Location: Cytoplasm.
Tissue Specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Domain: The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme.
Ptm: Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins.
Disease: Defects in PTPN11 are the cause of LEOPARD syndrome [MIM:151100]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.
Disease: Defects in PTPN11 are the cause of Noonan syndrome 1 (NS1) [MIM:163950]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.
Disease: Defects in PTPN11 are a cause of Noonan-like syndrome [MIM:163955]; also known as Noonan-like/multiple giant cell lesion syndrome. It is an autosomal dominant disorder characterized by Noonan features associates with giant cell lesions of bone and soft tissue.
Disease: Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Similarity: Contains 2 SH2 domains.
Similarity: Contains 1 tyrosine-protein phosphatase domain.
SHP-2 (Phospho-Tyr542) reacts with human, mouse, rat.
OMIM: 151100; phenotype. [NCBI / EBI]
163950; phenotype. [NCBI / EBI]
163955; phenotype. [NCBI / EBI]
176876; gene. [NCBI / EBI]
607785; phenotype. [NCBI / EBI]
Products similar to SHP-2 antibody:
IgG
 SHP-2 (Ab-580), IgG
SHP2 phospho S576, IgG
SHP2, IgG
SHP-2 (Ab-542), IgG
SHP2 phospho Y542, IgG
Protein
Tyrosine-protein phosphatase non-receptor type 11, Protein
|
|
| PRODUCT INTERACTIONS: |
SHP-2 (Phospho-Tyr542) interacts with GAB1 (GRB2-associated binding protein 1), IgG (GenWay Catalog #: 18-785-210412).
SHP-2 (Phospho-Tyr542) interacts with Gab1(Phospho-Tyr627) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-785-210412).
SHP-2 (Phospho-Tyr542) interacts with GAB1 (ready-to-use), IgG (GenWay Catalog #: 18-785-210412).
SHP-2 (Phospho-Tyr542) interacts with GAB1 phospho Y627, IgG (GenWay Catalog #: 18-785-210412).
SHP-2 (Phospho-Tyr542) interacts with Gab1, IgG (GenWay Catalog #: 18-785-210412).
SHP-2 (Phospho-Tyr542) interacts with PTP1B, IgG (GenWay Catalog #: 18-785-210412).
|
|
|
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
|
|
| BACKGROUND
REFERENCES for SHP-2 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Adachi M., Sekiya M., Miyachi T., Matsuno K., Hinoda Y., Imai K., Yachi A.
Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.
[2] Freeman R.M. Jr., Plutzky J., Neel B.G.
Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
[3] Bastien L., Ramachandran C., Liu S., Adam M.
Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase.
[4] Ahmad S., Banville D.L., Zhao Z., Fischer E.H., Shen S.H.
A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.
[5] Vogel W., Lammers R., Huang J., Ullrich A.
Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
[6] Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., et al.
Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
[7] Bennett A.M., Tang T.L., Sugimoto S., Walsh C.T., Neel B.G.
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
[8] Ohnishi H., Kubota M., Ohtake A., Sato K., Sano S.
Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.
[9] Kharitonenkov A., Chen Z., Sures I., Wang H., Schilling J., Ullrich A.
A family of proteins that inhibit signalling through tyrosine kinase receptors.
[10] Marie-Cardine A., Kirchgessner H., Bruyns E., Shevchenko A., Mann M., Autschbach F., Ratnofsky S., Meuer S., Schraven B.
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T-cell activation. |
|
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: SHP-2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of SHP-2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SHP-2 antibody, all related information, articles, resources about SHP-2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
|
|
|
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
|
|
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
|
|
|
