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Akt (Phospho-Thr308) Antibody Blocking Peptide peptide Printer Friendly Datasheet
Catalog Number: 06-785-213052
Buy AKT1 peptide - Size:   
  Related Product Names:
- AKT1 peptide; AKT1; PKB; RAC; Akt (Phospho-Thr308) Antibody Blocking Peptide
- EC 2.7.11.1; RAC-PK-alpha; Protein kinase B; PKB; C-AKT; RAC-alpha serine/threonine-protein kinase
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
 Gene Name: AKT1  Gene Name Synonym: PKB; RAC

 Gi #: N/A
 NCBI Acc #: NP_001014431.1
 Swiss Prot Acc #: P31749

 Length (aa): N/A
 Mol. Weight (Da): 55686
 Chrom Location: N/A
 Shipping: Products may be shipped on ice pack or dry ice.
 TESTING: (secondary reagents and protocols )
 Not Available
 AKT1 PEPTIDE TARGET DESCRIPTION:
Synonym Names for AKT1 peptide: AKT1; PKB; RAC; EC 2.7.11.1; RAC-PK-alpha; Protein kinase B; PKB; C-AKT; RAC-alpha serine/threonine-protein kinase

Function: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Catalytic Activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme Regulation: Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the C-terminal regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation.

Subunit: Interacts with CENTG1 isoform 2 (PIKE-A) in the presence of guanine nucleotides. The C-terminus interacts with CCDC88A/GRDN and THEM4. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression.

Subcellular Location: Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A.

Tissue Specificity: In all human cell types so far analyzed.

Domain: Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.

Domain: The AGC-kinase C-terminal mediates interaction with THEM4.

Ptm: Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Ser-473 phosphorylation by the Rictor-mTor complex favors Thr-308 phosphorylation by PDPK1. Ser-473 phosphorylation is enhanced by interaction with CENTG1 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells.

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

Similarity: Contains 1 AGC-kinase C-terminal domain.

Similarity: Contains 1 PH domain.

Similarity: Contains 1 protein kinase domain.

OMIM: 164730; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Adipocytokine signaling pathway 04920
KEGG pathway: Apoptosis 04210
KEGG pathway: B cell receptor signaling pathway 04662
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: Colorectal cancer 05210
KEGG pathway: Endometrial cancer 05213
KEGG pathway: ErbB signaling pathway 04012
KEGG pathway: Fc epsilon RI signaling pathway 04664
KEGG pathway: Focal adhesion 04510
KEGG pathway: Glioma 05214
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: Jak-STAT signaling pathway 04630
KEGG pathway: MAPK signaling pathway 04010
KEGG pathway: Melanoma 05218
KEGG pathway: Non-small cell lung cancer 05223
KEGG pathway: Pancreatic cancer 05212
KEGG pathway: Prostate cancer 05215
KEGG pathway: Renal cell carcinoma 05211
KEGG pathway: Small cell lung cancer 05222
KEGG pathway: T cell receptor signaling pathway 04660
KEGG pathway: Tight junction 04530
KEGG pathway: Toll-like receptor signaling pathway 04620
KEGG pathway: VEGF signaling pathway 04370
KEGG pathway: mTOR signaling pathway 04150
Reactome Event:Apoptosis 109581
Reactome Event:Metabolism of nitric oxide 202131
Reactome Event:Regulation of beta-cell development 186712
Reactome Event:Signaling in Immune system 168256
Reactome Event:Signalling by NGF 166520

Products similar to AKT1 peptide:
 IgG
    IL16 [323], IgG
    PGP9.5, IgG
    NCOR1 (nuclear receptor co-repressor 1), IgG
    AKT1, IgG
    AMACR + p63 [4A4 (p63)], IgG
 Native_Protein
    PKB (AKT) (460-480) Peptide, Native_Protein
    Akt (Phospho-Ser473) Antibody Blocking Peptide, Peptide
    Akt1 (inactive) HUMAN, Protein
    RAC-alpha serine/threonine-protein kinase, Protein
    AKT1 Human, Protein
 PRODUCT INTERACTIONS:
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with B-cell lymphoma/leukemia 10, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Bcl-10, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Bcl10 [Carmen-1], IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Bcl10, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Bcl10 [151], IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Bcl10, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with CDC37, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Glycogen synthase kinase-3 beta, Protein (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with GSK3-beta, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with GSK3-beta (Phospho-Ser9), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with GSK3-beta (Phospho-Tyr216), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with GSK3-beta (Ab-9), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with GSK3-beta (Ab-216), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with GSK3-beta (Phospho-Ser9) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Rabbit anti GSK3b pS9, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Phospho-Ser9 GSK3-beta, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Anti-GSK3 beta pS9, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with ASK1, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with ASK1 (Phospho-Ser83), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with ASK1 (Phospho-Ser966), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with ASK1 (Ab-83), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with ASK1 (Ab-966), IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with ASK1 (Phospho-Ser83) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with ASK1 (Phospho-Ser966) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Rabbit anti ASK-1 pS83, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with Anti-ASK-1 phospho specific pS83, IgG (GenWay Catalog #: 06-785-213052).
 Akt (Phospho-Thr308) Antibody Blocking Peptide interacts with SETDB1, IgG (GenWay Catalog #: 06-785-213052).
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: AKT1 peptide is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of AKT1 peptide vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about AKT1 peptide, all related information, articles, resources about AKT1 peptide are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

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