NFKB1 peptide, NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide peptide

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Peptides \| Secondary Antibodies \| ELISA Kits

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide peptide

Catalog Number: 06-785-213190

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Related Product Names:

- NFKB1 peptide; NFKB1; NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide
- DNA-binding factor KBF1; EBP-1; Nuclear factor NF-kappa-B p105 subunit

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: NFKB1	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_003989.2	Swiss Prot Acc #: P19838
Length (aa): N/A	Mol. Weight (Da): 105356	Chrom Location: N/A

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

NFKB1 PEPTIDE TARGET DESCRIPTION:

Synonym Names for NFKB1 peptide: NFKB1; DNA-binding factor KBF1; EBP-1; Nuclear factor NF-kappa-B p105 subunit

Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

Subunit: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity).

Subcellular Location: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).

Induction: By phorbol ester and TNF-alpha.

Domain: The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.

Domain: Glycine-rich region (GRR) appears to be a critical element in the generation of p50.

Ptm: While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.

Ptm: Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis.

Ptm: Polyubiquitination seems to allow p105 processing.

Ptm: S-nitrosylation of Cys-61 affects DNA binding.

Similarity: Contains 7 ANK repeats.

Similarity: Contains 1 death domain.

Similarity: Contains 1 RHD (Rel-like) domain.

OMIM: 164011; gene. [NCBI / EBI]

Products similar to NFKB1 peptide:

IgG

NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)), IgG

PRODUCT INTERACTIONS:

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with HDAC1 (histone deacetylase 1), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with HDAC1 [HDAC1-21], IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Anti-HDAC-1, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with HDAC1, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with HDAC1 (ready-to-use), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with HDAC1, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with RELA, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkB p65, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Phospho-Ser529), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Ab-529), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 ( (phospho-Ser311), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Ab-311), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Phospho-Thr254), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Phospho-Ser276), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Phospho-Thr435), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Phospho-Ser468), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Phospho-Ser536), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Ab-254), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Ab-276), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB -p65 (Ab-435), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Ab-468), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NF-kappaB-p65 (Ab-536), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkappaB-p65 (Phospho-Thr254) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkappaB-p65 (Phospho-Ser276) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkappaB-p65 (Phospho-Thr435) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkappaB-p65 (Phospho-Ser468) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkappaB-p65 (Phospho-Ser536) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkappaB-p65 (Phospho-Ser529) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkappaB-p65 (phospho-Ser311) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Rabbit anti p65 (RelA) N-terminal, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Rabbit anti p65 (RelA) C-terminal, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Anti-NFKB p65 (Rel A) phospho specific pS276, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Anti-NFKB p65 (Rel A) phospho specific pS529, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Anti-NFKB p65 (Rel A), IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Anti-NFKB p65 (Rel A) N-TERMINAL SPECIFIC, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Anti-NFKB p65 (Rel A) phospho specific pS536, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with Anti-NFKB p65 NLS specific, IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkB p65 [NF-12], IgG (GenWay Catalog #: 06-785-213190).

NFkappaB-p105/p50 Phospho-Ser932) Antibody Blocking Peptide interacts with NFkB p65, IgG (GenWay Catalog #: 06-785-213190).

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: NFKB1 peptide is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of NFKB1 peptide vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NFKB1 peptide, all related information, articles, resources about NFKB1 peptide are being stored on our online database. Let us know if you have questions regarding this product.

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