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HER-2/Neu (c-erbB-2) Antibody, Mouse Monoclonal Antibody Printer Friendly Datasheet
Catalog Number: 20-511-240030
Buy ERBB2 antibody - Size:   
  Related Product Names:
- ERBB2 antibody; ERBB2; HER2; NEU; NGL; HER-2/Neu (c-erbB-2)
- MAb to HER-2/Neu (c-erbB-2); EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen; Receptor tyrosine-protein kinase erbB-2
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
 Gene Name: ERBB2  Gene Name Synonym: HER2; NEU; NGL

 Gi #: N/A
 NCBI Acc #: NP_001005862.1
 Swiss Prot Acc #: P04626

 Length (aa): N/A
 Mol. Weight (Da): 137910
 Chrom Location: N/A
 Isotype: IgG1

 Clone: B3825M

 Host Animal: Mouse

 Immunogen: Synthetic peptide: Cys-Lys-Gly-Thr-Pro-Thr-Ala-Glu-Asp-Pro-Glu-Tyr-Leu-Gly-Leu-Asp-Val-Pro-Val (amino acids 1238–1255) selected from the cytoplasmic domain of human c-erbB-2 protein.

 Specificity: Recognizes c-erbB-2 which is a membrane associated oncoprotein that has considerable sequence homology with EGFR. Western blot of SK-BR-3 mammary adenocarcinoma cell line detects two major protein bands at 170kDa and 180kDa. The 170kDa protein is thought to be a degradation fragment of the c-erbB-2 protein in which the immunoreactive epitope is conserved. These bands were not detected when the antibody was adsorbed with c-erbB-2 derived peptide. Does not detect any bands on immunoblots of A431 epidermoid carcinoma cell line. showing that despite sequence similarity. the antibody does not cross-react with EGFR.

 Type of Product: Monoclonal Antibodies for Cancer Research

 Concentration: 100ug/ml

 Preservatives: NaN3

 Buffer: PBS containing 1mg/ml BSA

 Applications Notes : Suitable for use in Western blot, flow cytometry, and immunohistocytochemistry (formalin fixed, paraffin embedded sections and frozen sections). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

 Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

 Source/Host: Mouse

 Purity/Purification: Protein A chromatography

 Clonality: Monoclonal

 Format: Purified, Liquid

 Storage: Short term (up to one month) store at 2-8 C. Long term, aliquot and store at -20 C. Avoid multiple freeze-thaw cycles.

 Shipping: Products may be shipped on ice pack or dry ice.
 APPLICATIONS for ERBB2 ANTIBODY:
 WB, ICC(f, p), Flow Cytometry (FACS): Tested
 TESTING: (secondary reagents and protocols )
 Not Available
 ERBB2 ANTIBODY TARGET DESCRIPTION:
Synonym Names for ERBB2 antibody: ERBB2; HER2; NEU; NGL; MAb to HER-2/Neu (c-erbB-2); EC 2.7.10.1; p185erbB2; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 antigen; Receptor tyrosine-protein kinase erbB-2

MAb to HER-2/Neu (c-erbB-2). Monoclonal Antibody to Human HER-2/Neu (c-erbB-2), amino acids 1238–1255

Function: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Ptm: Ligand-binding increases phosphorylation on tyrosine residues (By similarity).

Polymorphism: There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012.

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

Similarity: Contains 1 protein kinase domain.

OMIM: 164870; gene. [NCBI / EBI]

Products similar to ERBB2 antibody:
 IgG
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    Neurofibrillary tangles, IgG
    ErbB2 [ICR55], IgG
    PGP9.5, IgG
 Peptide
    HER2 (Phospho-Tyr877) Antibody Blocking Peptide, Peptide
    HER2 (Phospho-Tyr1248) Antibody Blocking Peptide, Peptide
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    ErbB-2 Human, Protein
 PRODUCT INTERACTIONS:
 HER-2/Neu (c-erbB-2) interacts with EGF R, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (ready-to-use), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [ICR10], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [Cocktail R19/48 (111.6 + 199.12 + F4 + 11E8)], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [199.12], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [2E9], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with Acitve EGF Receptor EIA Kit, ELISA_Kits (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Ser1070), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Tyr1092), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Thr678), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Thr693), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Tyr1172), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Tyr1197), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Tyr869), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (phospho-Tyr1110), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-1070), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-1092), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-678), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-693), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-1172), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-1197), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-869), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Ab-1110), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Ser1070) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Tyr1092) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR(Phospho-Tyr1172) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Tyr1197) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Phospho-Tyr869) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (phospho-Tyr1110) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (External Domain), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (Internal Domain), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR pTyr 845, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR (a.a. 1165-1186), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR dpTyr 1173, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR, Activated pTyr 1173, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR pS1047, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR pThr 654, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR, pTyr 1045, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGF Receptor (non-ligand binding site), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGF Receptor (ligand binding site), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGF Receptor, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGF Receptor, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with Rabbit anti EGFR (a.a. 1168-1181), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with Rabbit anti EGF Receptor, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR Human Sf9, Protein (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR Human, Protein (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR Human Sf9, Protein (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with Anti-Epidermal Growth Factor Receptor (EGFR) pY1197, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with Anti-Epidermal Growth Factor Receptor (EGFR) pY1197, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [ICR10] (FITC), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [29.1], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR phospho Y1148, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [SP9] (ready-to-use), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [EGFR1], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGF R, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR phospho Y1173, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR phospho Y1068, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR phospho Y845, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [F4], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [ICR61], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [R19/48], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [H9B4], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [F4], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR phospho Y1086, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR phospho Y992, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGFR [F4] (FITC), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with EGF R, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with epidermal growth factor receptor isoform a precursor, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with epidermal growth factor receptor isoform a precursor, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with epidermal growth factor receptor isoform a precursor, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB3, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB3 (ready-to-use), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB3 [RTJ1], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with Rabbit anti HER3 (a.a. 1283-1323), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB3 Human, Protein (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with Anti-HER3, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB3, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB3, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB4, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB4, IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB4 [SPM338] (ready-to-use), IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB4 [H4.77.16], IgG (GenWay Catalog #: 20-511-240030).
 HER-2/Neu (c-erbB-2) interacts with ErbB4 (ready-to-use), IgG (GenWay Catalog #: 20-511-240030).
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ERBB2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ERBB2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ERBB2 antibody, all related information, articles, resources about ERBB2 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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