Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Peptides
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Secondary Antibodies
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ELISA Kits
MAb Oligodendrocytes & Myelin Antibody, Mouse Monoclonal Antibody
Catalog Number: 20-511-240133
Buy Mbp antibody -
Size:
0.125 mg ($400.00)
Related Product Names:
- Mbp antibody; Mbp; Shi; MAb Oligodendrocytes & Myelin
- MAb Oligodendrocytes & Myelin; MBP; Myelin A1 protein; Myelin basic protein
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
Mbp
Gene Name Synonym:
Shi
Gi #:
N/A
NCBI Acc #:
N/A
Swiss Prot Acc #:
P04370
Length (aa):
N/A
Mol. Weight (Da):
27168
Chrom Location:
N/A
Isotype:
IgG1
Clone:
HPC-7
Host Animal:
Mouse
Immunogen:
Adult rat hippocampal membranes
Specificity:
Stains Oligodendrocytes and myelin in the CNS.
Type of Product:
Monoclonal Antibodies for Neuroscience
Concentration:
0.5mg/ml (OD280nm)
Preservatives:
NaN3
Buffer:
0.01M PBS, pH 7.2 containing 1% BSA
Applications Notes :
Suitable for use in immunohistochemistry (1:50). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Source/Host:
Mouse
Purity/Purification:
Protein G chromatography
Clonality:
Monoclonal
Format:
Purified, Liquid
Storage:
Short-term (up to one month) store at 2-8 C. Long term, aliquot and store at -20 C. Avoid multiple freeze/thaw cycles.
Shipping:
Products may be shipped on ice pack or dry ice.
TESTING: (
secondary reagents
and
protocols
)
Not Available
MBP ANTIBODY TARGET DESCRIPTION:
Synonym Names for Mbp antibody:
Mbp; Shi; MAb Oligodendrocytes & Myelin; MBP; Myelin A1 protein; Myelin basic protein
MAb Oligodendrocytes & Myelin. Monoclonal Antibody to Oligodendrocytes and Myelin (CNS)
Function:
The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS, AND MASS SPECTROMETRY. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.
Subunit:
Homodimer (By similarity).
Subcellular Location:
Isoform 13: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 12: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 11: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 10: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 9: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 8: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 7: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 6: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 5: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 4: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.
Subcellular Location:
Isoform 3: Cytoplasm. Nucleus.
Subcellular Location:
Isoform 2: Cytoplasm. Nucleus.
Subcellular Location:
Isoform 1: Cytoplasm. Nucleus.
Tissue Specificity:
In the embryo, isoform 1-isoform 3 are found in neurons within the central nervous system (primarily in pioneer neurons important in the formation of the cortex) and the peripheral nervous system. They are also expressed in the thymus, gut, lung and kidney. In the adult, isoform 1-isoform 3 are highly expressed in the brain (mainly in brain regions rich in oligodendrocytes) and spleen. Lower levels are seen in the heart, kidney and lung. Isoform 2 is also found in cells of the immune system. The isoforms missing the 134 first amino acids (isoform 4-isoform 13) are almost exclusively produced in the myelin-forming cells, the mature oligodendrocytes.
Developmental Stage:
The differential expression of MBP isoforms is developmentally regulated. Isoform 2 and isoform 3 are first expressed during embryonic stages (as early as at embryonic day 11.5), expression of isoform 1 is turned on shortly after birth. Expression of the isoforms missing the 134 first amino acids occurs later, presumably as the oligodendrocytes approach their terminally differentiated state.
Ptm:
As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.
Ptm:
Methylated on arginine residues; decreases with the age of the animal, making MBP more cationic.
Disease:
Defects in Mbp are a cause of dysmyelinating diseases such as the shiverer (SHI) and myelin deficient (MLD) diseases characterized by decreased myelination in the CNS, tremors, and convulsions of progressively increasing severity leading to early death. The shiverer mice only express isoform 2, the MLD mice have a reduced amount of Mbp.
Similarity:
Belongs to the myelin basic protein family.
Products similar to Mbp antibody:
IgG
Potassium voltage-gated channel subfamily C member 1, IgG
ENO1 (enolase 1. (alpha)), IgG
ENO1 (enolase 1. (alpha)), IgG
Amyloid Precursor Protein Frameshift Mutant, IgG
Myelin basic protein [B103.1], IgG
Native_Protein
Non-Neuronal Enolase (NNE), Native_Protein
ALPHA 1 MICROGLOBULIN, Native_Protein
UTI Human, Native_Protein
MYELIN, Native_Protein
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
Mbp antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of Mbp antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Mbp antibody, all related information, articles, resources about Mbp antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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