IGF1R antibody, IGF-Ir Antibody, Mouse Monoclonal Antibody

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IGF-Ir Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-511-240488

Buy IGF1R antibody -

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Related Product Names:

- IGF1R antibody; IGF1R; IGF-Ir
- MAb to IGF-Ir; EC 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: IGF1R	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_000866.1	Swiss Prot Acc #: P08069
Length (aa): N/A	Mol. Weight (Da): 154793	Chrom Location: N/A

Isotype: IgG1

Clone: 1H7

Host Animal: Mouse

Immunogen: Purified human placental IGF-1 Receptors

Specificity: Specific for the human IGF-1 receptor. and recognizes the alpha subunit. Inhibits binding of IGF-1 and IGF-2; inhibits cell growth.

Type of Product: Monoclonal Antibodies to Cytokines and Growth Factors

Concentration: 0.3mg/ml (OD280nm)

Buffer: PBS, pH 7.4

Applications Notes : Use in research studies to delineate signal transduction pathways specific for IGF's and for detecting IGF-1 receptors in crude samples. Can recognize the IGF-1 alpha subunit on immunoblots.

Source/Host: Mouse

Purity/Purification: Protein G chromatography

Clonality: Monoclonal

Format: Purified, Liquid

Storage: Store at -20 C to -70 C. Aliquot to avoid multiple freeze/thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

IGF1R ANTIBODY TARGET DESCRIPTION:

Synonym Names for IGF1R antibody: IGF1R; MAb to IGF-Ir; EC 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor

MAb to IGF-Ir. Monoclonal Antibody to Insulin Growth Factor I Receptor (IGF-Ir)

Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.

Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme Regulation: Autophosphorylation activates the kinase activity.

Subunit: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Tissue Specificity: Expressed in a variety of tissues.

Ptm: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).

Ptm: Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.

Disease: Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Similarity: Contains 3 fibronectin type-III domains.

Similarity: Contains 1 protein kinase domain.

OMIM: 147370; gene. [NCBI / EBI]
270450; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Adherens junction 04520
KEGG pathway: Colorectal cancer 05210
KEGG pathway: Focal adhesion 04510
KEGG pathway: Glioma 05214
KEGG pathway: Long-term depression 04730
KEGG pathway: Melanoma 05218
KEGG pathway: Prostate cancer 05215

Products similar to IGF1R antibody:

IgG

IGF1 receptor, IgG

IGF1 receptor [alphaIR3], IgG

PRODUCT INTERACTIONS:

IGF-Ir interacts with 14-3-3 Gamma Human, Protein (GenWay Catalog #: 20-511-240488).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: IGF1R antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of IGF1R antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about IGF1R antibody, all related information, articles, resources about IGF1R antibody are being stored on our online database. Let us know if you have questions regarding this product.

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