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| FGF Receptor 1 alpha Antibody, Mouse Monoclonal Antibody |
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| Catalog Number: 20-511-240492 |
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| Related Product Names:
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FGFR1 antibody; FGFR1; FGFBR; FLG; FLT2; FGF Receptor 1 alpha
- MAb to FGF Receptor 1 alpha; FGFR-1; bFGF-R; EC 2.7.10.1; Fms-like tyrosine kinase 2; c-fgr; CD331 antigen; Basic fibroblast growth factor receptor 1 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: FGFR1 |
Gene Name Synonym: FGFBR; FLG; FLT2 |
Gi #:
N/A |
NCBI Acc #:
N/A |
Swiss Prot Acc #:
P11362 |
Length (aa): N/A |
Mol. Weight (Da): 91868 |
Chrom Location: N/A |
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 Isotype: IgG2a
Clone: M2F12
Host Animal: Mouse
Immunogen: Recombinant human ectodomain of FGFr1a expressed in E. coli beginning with pro23. antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences.
Specificity: Reacts with the NH2-terminus of unique NH2-terminal Ig loop of FGFr1. Epitope is within the sequence between glu30 and ala74 of FGFr1a. Reacts with human. rat and mouse receptors.
Type of Product: Monoclonal Antibodies to Cytokines and Growth Factors
Concentration: 0.7mg/ml (OD280nm)
Buffer: PBS, pH 7.4
Applications Notes : Western blotting: 1ug/ml recognizes 10ng recombinant bacterial, baculoviral or native FGFr1.. Immunoprecipitation: native, nuclear, recombinant and ligand-labeled FGFr1.. Immunohistochemistry: frozen sections of human glioblastomas, paraformaldehyde-fixed cells and nuclei, human myocardial biopsies.. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Source/Host: Mouse
Purity/Purification: Protein G chromatography
Clonality: Monoclonal
Format: Purified, Liquid
Storage: Aliquot and store (up to 1 year) at -20 C to -70 C. Avoid multiple freeze/thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| FGFR1 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for FGFR1 antibody: FGFR1; FGFBR; FLG; FLT2; MAb to FGF Receptor 1 alpha; FGFR-1; bFGF-R; EC 2.7.10.1; Fms-like tyrosine kinase 2; c-fgr; CD331 antigen; Basic fibroblast growth factor receptor 1
MAb to FGF Receptor 1 alpha. Monoclonal Antibody to Human Fibroblast Growth Factor Receptor 1 alpha (FGFr1a)
Function: Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF).
Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Interacts with SHB. Interacts with KLB (By similarity).
Subcellular Location: Membrane; Single-pass type I membrane protein.
Ptm: Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.
Disease: Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.
Disease: Defects in FGFR1 are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadism is a condition characterized by abnormally decreased gonadal function, with retardation of growth and sexual development. Hypogonadotropic hypogonadism is due to inadequate secretion of gonadotropins. It results from failure to release sufficient gonadotropin-releasing hormone.
Disease: Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous.
Disease: Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant.
Disease: Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome.
Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.
Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
Disease: A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity: Contains 1 protein kinase domain.
OMIM: 101600; phenotype. [NCBI / EBI]
136350; gene. [NCBI / EBI]
146110; phenotype. [NCBI / EBI]
147950; phenotype. [NCBI / EBI]
166250; phenotype. [NCBI / EBI]
190440; phenotype. [NCBI / EBI]
Products similar to FGFR1 antibody:
IgG
 FGFR1, IgG
FGFR1 alpha [M1C4], IgG
FGFR1 [M19B2], IgG
FGF Receptor 1, IgG
Filaggrin [FLG01], IgG
Protein
FGFR1 Human, Protein
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| PRODUCT INTERACTIONS: |
FGF Receptor 1 alpha interacts with E-cadherin, Reagents (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Cadherin-1 (E-cadherin), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with E Cadherin [67A4], IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with pan Cadherin [CH-19], IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Human E-cadherin EIA Kit, ELISA_Kits (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with E-Cadherin, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Cadherin-E Human, Protein (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with E Cadherin [DECMA-1], IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with pan Cadherin [CH-19] (FITC), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with pan Cadherin (ready-to-use), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with pan Cadherin, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with E Cadherin (ready-to-use), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with E Cadherin, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with CD324, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with E-Cadherin, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with E-Cadherin Phospho (pS838/840), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with CTNNB1, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with CATENIN, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with b-Catenin (CTNNB1) Dephospho, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with b-Catenin (CTNNB1), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with BETA-CATENIN, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta Catenin [6F9], IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta Catenin [15B8], IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta-Catenin (Phospho-Thr41/Ser45), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with b-Catenin (Ab-41/45), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta-Catenin (Phospho-Ser33), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta-Catenin (Phospho-Ser37), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin (Ab-33), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin (Ab-37), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta-Catenin (Phospho-Thr41/Ser45) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta-Catenin (Phospho-Ser33) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta-Catenin (Phospho-Ser37) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin beta, C-terminal (exon 14), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin beta, N-terminal (exon 2), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin, beta, Core, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin beta, C-terminal (a.a. 769-781), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin, beta, dephosphorylated (35-50), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin beta, pTyr 86, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin beta, pTyr 654, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Catenin beta,(exon 3), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta Catenin phospho S33, S37 [BC-22], IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta Catenin [15B8] (Cy3), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta Catenin (ready-to-use), IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta Catenin, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta Catenin phospho S33 [BC-76], IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with beta-catenin, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Beta-Catenin, IgG (GenWay Catalog #: 20-511-240492).
FGF Receptor 1 alpha interacts with Beta-Catenin Phospho (pT41/pT45), IgG (GenWay Catalog #: 20-511-240492).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: FGFR1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of FGFR1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FGFR1 antibody, all related information, articles, resources about FGFR1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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