ITGA2B antibody, CD41 gp11b/111a Antibody, Mouse Monoclonal Antibody

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CD41 gp11b/111a Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-511-241112

Buy ITGA2B antibody -

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Related Product Names:

- ITGA2B antibody; ITGA2B; GP2B; ITGAB; CD41 gp11b/111a
- MAb to CD41 gp11b/111a; Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen; Integrin alpha-IIb

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ITGA2B	Gene Name Synonym: GP2B; ITGAB
Gi #: N/A	NCBI Acc #: NP_000410.2	Swiss Prot Acc #: P08514
Length (aa): N/A	Mol. Weight (Da): 113391	Chrom Location: N/A

Isotype: IgG1

Clone: M148

Host Animal: Mouse

Specificity: CD41. Platelet gpIIb IIIa

Type of Product: Monoclonal Antibodies to Human CDs

Concentration: 100ug/ml (OD280)

Preservatives: NaN3

Buffer: 0.01M PBS, pH 7.2 containing 2.0mM EDTA, 1.0% BSA.

Applications Notes : This antibody inhibits platelet aggregation by ADP, sodium arachidonate, collagen, and thrombin (1). We recommend using 1ug to stain 1.0 x 106 cells in flow cytometric applications. However, each investigator should determine their own optimal working dilution for use in other specific research applications.

Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Source/Host: Mouse

Purity/Purification: Protein G

Clonality: Monoclonal

Format: Purified, Liquid

Storage: Short-term store at 2-8 C. Long term, aliquot and store below -20 C. Avoid multiple freeze/thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

ITGA2B ANTIBODY TARGET DESCRIPTION:

Synonym Names for ITGA2B antibody: ITGA2B; GP2B; ITGAB; MAb to CD41 gp11b/111a; Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen; Integrin alpha-IIb

MAb to CD41 gpIIb/IIIa. Monoclonal Antibody to CD41 gpIIb/IIIa

Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Tissue Specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.

Polymorphism: Position 874 is associated with platelet-specific alloantigen HPA-3/BAK/LEK. HPA-3A/BAK(A)/LEK(A) has Ile-874 and HPA-3B/BAK(B)/LEK(B) has Ser-874. HPA-3B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP).

Disease: Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.

Similarity: Belongs to the integrin alpha chain family.

Similarity: Contains 7 FG-GAP repeats.

OMIM: 273800; phenotype. [NCBI / EBI]
607759; gene. [NCBI / EBI]

Pathways:
KEGG pathway: ECM-receptor interaction 04512
KEGG pathway: Focal adhesion 04510
KEGG pathway: Hematopoietic cell lineage 04640
KEGG pathway: Regulation of actin cytoskeleton 04810
KEGG pathway: Small cell lung cancer 05222
Reactome Event:Hemostasis 109582

Products similar to ITGA2B antibody:

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CD41, IgG

CD41 gpIIb IIIa, IgG

CD41 gpIIb/IIIa, IgG

CD41a [B398 (96.2C1)] (FITC), IgG

Integrin alpha 2b [M148] (Biotin), IgG

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Precautions: ITGA2B antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ITGA2B antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ITGA2B antibody, all related information, articles, resources about ITGA2B antibody are being stored on our online database. Let us know if you have questions regarding this product.

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