ABO antibody, Hab Human Blood Antigen Antibody, Mouse Monoclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Hab Human Blood Antigen Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-511-242059

Buy ABO antibody -

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Related Product Names:

- ABO antibody; ABO; Hab Human Blood Antigen
- MAb to Hab Human Blood Antigen; NAGAT; Histo-blood group ABO system transferase

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ABO	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_065202.2	Swiss Prot Acc #: P16442
Length (aa): N/A	Mol. Weight (Da): 40934	Chrom Location: N/A

Isotype: IgM

Clone: 87-N

Host Animal: Mouse

Specificity: Hab Human Blood Antigen

Type of Product: Monoclonal Antibodies to Platelets and Hemostasis Antigens

Concentration: ~1mg/ml

Preservatives: NaN3

Buffer: 0.3M Sodium chloride, 1.25mM EDTA

Applications Notes : Suitable for use in ELISA and absorption-elution test. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Source/Host: Mouse

Purity/Purification: Protein A chromatography

Clonality: Monoclonal

Format: Purified, Liquid

Storage: Store (up to 1 year) at 2-8 C. DO NOT FREEZE.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ABO ANTIBODY:

ELISA, Flow Cytometry (FACS), IHC-F, IP , WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

ABO ANTIBODY TARGET DESCRIPTION:

Synonym Names for ABO antibody: ABO; MAb to Hab Human Blood Antigen; NAGAT; Histo-blood group ABO system transferase

MAb to Hab Human Blood Antigen. Monoclonal Antibody to Hab Human Blood Antigen Antibody

Function: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal) whereas O individuals lack such activity.

Catalytic Activity: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactose.

Catalytic Activity: UDP-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.

Cofactor: Binds 1 manganese ion per subunit.

Pathway: Protein modification; protein glycosylation.

Subcellular Location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Domain: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.

Ptm: The soluble form derives from the membrane form by proteolytic processing.

Polymorphism: The sequence shown is that of the A transferase. The B form differs by a few residues substitutions. The O phenotype results from a single base frameshift in the N-terminal extremity of the gene, resulting in a severly truncated protein without catalytic activity.

Similarity: Belongs to the glycosyltransferase 6 family.

OMIM: 110300; gene+phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Glycan structures - biosynthesis 2 01031
KEGG pathway: Glycosphingolipid biosynthesis - lactoseries 00601
KEGG pathway: Glycosphingolipid biosynthesis - neo-lactoseries 00602

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ABO antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ABO antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ABO antibody, all related information, articles, resources about ABO antibody are being stored on our online database. Let us know if you have questions regarding this product.

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