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| Rabbit anti Ajuba Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-511-244025 |
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| Related Product Names:
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JUB antibody; JUB; Rabbit anti Ajuba
- Rabbit anti Ajuba; N/A; Protein ajuba |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: JUB |
Gene Name Synonym: N/A |
Gi #:
N/A |
NCBI Acc #:
NP_116265.1 |
Swiss Prot Acc #:
Q96IF1 |
Length (aa): N/A |
Mol. Weight (Da): 56934 |
Chrom Location: N/A |
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 Host Animal: Rabbit
Immunogen: Synthetic peptide corresponding to amino acids 224–239 of Human Ajuba.
Protein Sequence: CQESRHSYPPALGSPG
Specificity: Ajuba
Specificity: Recognizes human Ajuba (also called JUB protein and ajuba homolog isoform 1). A BLAST analysis suggests reactivity with this protein from human, rat, dog, mouse and chimpanzee based on 100% homology for the immunogen sequence. Cross reactivity with Ajuba protein from homologues from other sources has not been determined.
Type of Product: Polyclonal Antibodies for Cancer Research
Concentration: 1.67mg/ml (OD280nm)
Preservatives: NaN3
Buffer: 0.02M Potassium Phosphate, 0.15M Sodium Chloride, pH 7.2
Applications Notes : Suitable for use in ELISA (1:20,000–1:80,000) and Western blot (1:500–1:2,500). Expect a band at approximately 57 kDa. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Source/Host: Rabbit
Purity/Purification: Immunoaffinity chromatography
Clonality: Polyclonal
Format: Affinity Purified, Liquid
Storage: Upon receipt, store at -20 C. Prepare working dilution only prior to immediate use. Avoid multiple freeze/thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for JUB ANTIBODY: |
| ELISA, WB: Tested |
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| JUB ANTIBODY TARGET DESCRIPTION: |
Synonym Names for JUB antibody: JUB; Rabbit anti Ajuba; N/A; Protein ajuba
Rabbit anti Ajuba. Rabbit Antibody to Human Ajuba
Function: Components of cellular adhesives complexes. Contribute to cell fate determination and regulate cell proliferation and differentiation. Involved in the regulation of actin cytoskeleton dynamics and cell migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays a important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. Is also a component of the IL-1 signaling pathway modulating IL-1-induced NF-kappa-B activation by influencing the assembly and activity of the PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex. Can functions as adapter molecules in the formation of large multiprotein complexes that form on DNA and that influence transcription.
Subunit: Interacts with AURKA/Aurora-A during mitosis and both proteins are phosphorylated as they form a complex. Interacts with CTNNA1/alpha-catenin and with F-actin. Interacts with LATS2 during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts with GRB2 and PIP5K1A (By similarity). Forms a complex with SQSTM1, PRKCZ and TRAF6. Interacts with SLC1A2 (By similarity).
Subcellular Location: Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Centrosome. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co-localizes with cadherin-adhesive complexes at sites of cell-cell contacts.
Domain: LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments.
Domain: LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association between LATS2 and JUB required the second LIM domain of JUB.
Ptm: Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA.
Miscellaneous: 'Ajuba' means 'curiosity' in Urdu, an Indian dialect.
Similarity: Belongs to the zyxin/ajuba family.
Similarity: Contains 3 LIM zinc-binding domains.
OMIM: 609066; gene. [NCBI / EBI]
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: JUB antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of JUB antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about JUB antibody, all related information, articles, resources about JUB antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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