BACE2 antibody, Rabbit A' BACE 2 (a.a.496-511) Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Rabbit A' BACE 2 (a.a.496-511) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-511-244132

Buy BACE2 antibody -

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Related Product Names:

- BACE2 antibody; BACE2; AEPLC; ALP56; ASP21; Rabbit A' BACE 2 (a.a.496-511)
- Rabbit A' BACE 2 (a.a.496-511); EC 3.4.23.45; Beta-site APP-cleaving enzyme 2; Aspartyl protease 1; Asp 1; ASP1; Membrane-associated aspartic protease 1; Memapsin-1; Aspartic-like protease 56 kDa; Down region aspartic protease; Beta-secretase 2

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: BACE2	Gene Name Synonym: AEPLC; ALP56; ASP21
Gi #: N/A	NCBI Acc #: NP_036237.2	Swiss Prot Acc #: Q9Y5Z0
Length (aa): N/A	Mol. Weight (Da): 56180	Chrom Location: N/A

Host Animal: Rabbit

Immunogen: A peptide corresponding to amino acids 496 to 511 of human BACE2.(4)

Specificity: Beta Amyloid Cleaving Enzyme 2 (BACE 2) beta-Secretase C-term. (a.a. 496-511)

Specificity: Accumulation of the amyloid-beta (A-beta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A-beta peptide is generated by protoelytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2).(1-4) BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1.(4-9) BACE2 also cleaves APP at beta-site and at a different site within A-beta.(8) BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region'.

Type of Product: Polyclonal Antibodies for Neuroscience

Concentration: Lot specific

Preservatives: NaN3

Buffer: PBS

Applications Notes : Suitable for use in Western blot at 0.5 to 1ug/ml. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1â€“1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Source/Host: Rabbit

Purity/Purification: Immunoaffinity chromatography

Clonality: Polyclonal

Format: Affinity Purified, Liquid

Storage: Store at 2-8 C for up to one year.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for BACE2 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

BACE2 ANTIBODY TARGET DESCRIPTION:

Synonym Names for BACE2 antibody: BACE2; AEPLC; ALP56; ASP21; Rabbit A' BACE 2 (a.a.496-511); EC 3.4.23.45; Beta-site APP-cleaving enzyme 2; Aspartyl protease 1; Asp 1; ASP1; Membrane-associated aspartic protease 1; Memapsin-1; Aspartic-like protease 56 kDa; Down region aspartic protease; Beta-secretase 2

Rabbit A'BACE 2 (a.a.496-511). Rabbit Antibody to Human Beta Amyloid Cleaving Enzyme 2 (BACE2), Beta-Secretase, Carboxyl Terminal, amino acids 496-511

Catalytic Activity: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

Subunit: Interacts ith RTN3 and RTN4.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Similarity: Belongs to the peptidase A1 family [view classification].

OMIM: 605668; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Alzheimer's disease 05010

Products similar to BACE2 antibody:

IgG

Beta-secretase 2, IgG

Rabbit A' BACE 2 (a.a. 44-59), IgG

BACE2 (a.a. 44-59) Peptide, Peptide

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: BACE2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of BACE2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about BACE2 antibody, all related information, articles, resources about BACE2 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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