MAVS antibody, Rabbit anti VISA (Middle) Antibody, Rabbit Polyclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

Rabbit anti VISA (Middle) Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-511-244362

Buy MAVS antibody -

Size:

Related Product Names:

- MAVS antibody; MAVS; IPS1; KIAA1271; VISA; Rabbit anti VISA (Middle)
- Rabbit anti VISA (Middle); Interferon-beta promoter stimulator protein 1; IPS-1; Virus-induced-signaling adapter; CARD adapter inducing interferon-beta; Cardif; Putative NF-kappa-B-activating protein 031N; Mitochondrial antiviral-signaling protein

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: MAVS	Gene Name Synonym: IPS1; KIAA1271; VISA
Gi #: N/A	NCBI Acc #: NP_065797.2	Swiss Prot Acc #: Q7Z434
Length (aa): N/A	Mol. Weight (Da): 56528	Chrom Location: N/A

Host Animal: Rabbit

Immunogen: Synthetic peptide corresponding to 17 amino acids near the center of human VISA (Genbank No. NP_065797)

Specificity: VISA (Virus-induced signaling adapter) Middle region MAVS/CARD/Cardif/IPS-1

Specificity: Reacts with human, mouse and rat VISA. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-beta signaling pathways that recruits IRF-3 to RIG-1, leading to its activation and that of NF-kappaB.(2) VISA is thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. At least three isoforms of VISA are known to exist.

Type of Product: Polyclonal Antibodies to Apoptosis and Signal Transduction Reagents

Concentration: 1mg/ml

Preservatives: NaN3

Buffer: PBS

Applications Notes : Suitable for use in Western blot (0.5–1ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1â€“1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Source/Host: Rabbit

Purity/Purification: Immunoaffinity chromatography

Clonality: Polyclonal

Format: Affinity Purified, Liquid

Storage: Store (up to 1 year) at 2-8 C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for MAVS ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

MAVS ANTIBODY TARGET DESCRIPTION:

Synonym Names for MAVS antibody: MAVS; IPS1; KIAA1271; VISA; Rabbit anti VISA (Middle); Interferon-beta promoter stimulator protein 1; IPS-1; Virus-induced-signaling adapter; CARD adapter inducing interferon-beta; Cardif; Putative NF-kappa-B-activating protein 031N; Mitochondrial antiviral-signaling protein

Rabbit anti VISA (Middle). Rabbit Antibody to Human Virus-induced signaling adapter (VISA), Middle region MAVS/CARD/Cardif/IPS-1

Function: Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.

Subunit: Interacts with DDX58, IFIH1, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, IKBKE, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain.

Subcellular Location: Mitochondrion outer membrane.

Tissue Specificity: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.

Domain: Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.

Miscellaneous: Cleavage by HCV protease complex leads to inactivation.

Similarity: Contains 1 CARD domain.

OMIM: 609676; gene. [NCBI / EBI]

Products similar to MAVS antibody:

IgG

Rabbit anti VISA, N-term, IgG

PRODUCT INTERACTIONS:

Rabbit anti VISA (Middle) interacts with Inhibitor of nuclear factor kappa-B kinase alpha subunit, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK alpha [14A231], IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK -alpha (Phospho-Thr23), IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK -alpha (Ab-23), IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK -alpha (Phospho-Thr23) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Rabbit A' IKK-alpha, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK-alpha Control Peptide, Peptide (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Anti-IKK alpha, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Anti-IKK alpha CONTROL PEPTIDE, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK alpha phospho S176, S180, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Rabbit anti RIG-1, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Inhibitor of nuclear factor kappa B kinase subunit beta, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKKb, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK beta [10AG2], IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK beta [10A9B6], IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Rabbit A' IKK-beta, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK-beta Control Peptide, Peptide (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Anti-IKK beta, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Anti-IKK beta CONTROL PEPTIDE, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Inhibitor of nuclear factor kappa-B kinase epsilon subunit, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK iota + IKK epsilon [72B587], IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with IKK iota + IKK epsilon, IgG (GenWay Catalog #: 18-511-244362).

Rabbit anti VISA (Middle) interacts with Anti-IKKe pT501, IgG (GenWay Catalog #: 18-511-244362).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: MAVS antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of MAVS antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MAVS antibody, all related information, articles, resources about MAVS antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved