COL1A1 antibody, Rabbit A' Fish Collagen Type I Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Rabbit A' Fish Collagen Type I Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-511-244588

Buy COL1A1 antibody -

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Related Product Names:

- COL1A1 antibody; COL1A1; Rabbit A' Fish Collagen Type I
- Rabbit A' Fish Collagen Type I; Alpha-1 type I collagen; Collagen alpha-1(I) chain

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: COL1A1	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_000079.2	Swiss Prot Acc #: P02452
Length (aa): N/A	Mol. Weight (Da): 138911	Chrom Location: N/A

Host Animal: Rabbit

Immunogen: Collagen Type I extracted and purified from salmon fish skin

Specificity: Collagen Type I

Specificity: Cross-reactivity: (OD at a 1:100 ELISA dilution) Salmon Fish Collagen Type I >= 1.0
Sole and Tuna fish Collagen Type I < 0.4
Goldfish Collagen Type I <0.2*
Mammalian, avian Collagen Type I <0.2*
(*OD 0.2 means negative reactivity)

Type of Product: Polyclonal Antibodies to Collagens and Extracellular Matrix Proteins

Buffer: Not applicable

Applications Notes : Suitable for use in IFA, (SP)RIA, ELISA (tested). For immunostaining of extra or intracellular components in light microscopy and the quantitation of Salmon Type I collagen. In indirect IFA with fluorescein anti-rabbit IgG conjugate, use diluted at 1:40 on frozen salmon tissues (skin, liver). For ELISA, use diluted at 1:10 – 1:200. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Source/Host: Rabbit

Purity/Purification: Ion exchange chromatography

Clonality: Polyclonal

Format: Purified, Lyophilized Reconstitute with 0.5ml deionized water.

Storage: Lyophilized Store (up to 24 months) at 2-8 C. Long term store at -20 C. Reconstituted: Aliquot and store (up to 6 months) at -20 C. Avoid multiple freeze/thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

COL1A1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for COL1A1 antibody: COL1A1; Rabbit A' Fish Collagen Type I; Alpha-1 type I collagen; Collagen alpha-1(I) chain

Rabbit A' Fish Collagen Type I. Rabbit Antibody to Fish Collagen Type I

Function: Type I collagen is a member of group I collagen (fibrillar forming collagen).

Subunit: Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity).

Subcellular Location: Secreted, extracellular space, extracellular matrix (By similarity).

Tissue Specificity: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Ptm: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Ptm: O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

Disease: Defects in COL1A1 are the cause of Caffey disease [MIM:114000]; also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age.

Disease: Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.

Disease: Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A) [MIM:130060]; also known as autosomal dominant Ehlers-Danlos syndrome type VII. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7A is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations.

Disease: Defects in COL1A1 are a cause of osteogenesis imperfecta type I (OI-I) [MIM:166200]. OI-I is a dominantly inherited serious newborn disease characterized by bone fragility, normal stature, little or no deformity, blue sclerae and hearing loss in 50% of families. Dentinogenesis imperfecta is rare and may distinguish a subset of OI type I (formation of dentine).

Disease: Defects in COL1A1 are a cause of osteogenesis imperfecta type II (OI-II) [MIM:166210]; also known as osteogenesis imperfecta congenita. OI-II is lethal in the perinatal period and is charaterized by calvarial mineralization, beaded ribs, compressed femurs, marked long bone deformity and platyspondyly (congenital flattening of the vertebral bodies).

Disease: Defects in COL1A1 are a cause of osteogenesis imperfecta type III (OI-III) [MIM:259420]; also called progressively deforming osteogenesis imperfecta with normal sclerae. OI-III is characterized by progressively deforming bones, usually with moderate deformity at birth, sclerae is variable in color, dentinogenesis imperfecta and hearing loss are common. The stature is very short.

Disease: Defects in COL1A1 are a cause of osteogenesis imperfecta type IV (OI-IV) [MIM:166220]. OI-IV is charaterized by normal sclerae, moderate to mild deformity and variable short stature. Dentinogenesis imperfecta is common and hearing loss occurs in some patients.

Disease: Genetic variations in COL1A1 are associated with susceptibility to involutional osteoporosis [MIM:166710]; also known as senile osteoporosis or postmenopausal osteoporosis. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Disease: A chromosomal aberration involving COL1A1 is a cause of dermatofibrosarcoma protuberans (DFSP) [MIM:607907]. Translocation t(17;22)(q22;q13) with PDGF. DFSP is an uncommon, locally aggressive, but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It typically occurs during early or middle adult life and is most frequently located on the trunk and proximal extremities.

Similarity: Belongs to the fibrillar collagen family.

Similarity: Contains 1 VWFC domain.

OMIM: 114000; phenotype. [NCBI / EBI]
120150; gene. [NCBI / EBI]
130000; phenotype. [NCBI / EBI]
130060; phenotype. [NCBI / EBI]
166200; phenotype. [NCBI / EBI]
166210; phenotype. [NCBI / EBI]
166220; phenotype. [NCBI / EBI]
166710; phenotype. [NCBI / EBI]
259420; phenotype. [NCBI / EBI]
607907; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Cell Communication 01430
KEGG pathway: ECM-receptor interaction 04512
KEGG pathway: Focal adhesion 04510
Reactome Event:Hemostasis 109582
Reactome Event:Signaling in Immune system 168256

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Collagen I, IgG

Collagen I [COL-1], IgG

Collagen I, IgG

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Precautions: COL1A1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of COL1A1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about COL1A1 antibody, all related information, articles, resources about COL1A1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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