FGA antibody, Rabbit anti Mouse Fibrinogen Antibody, Rabbit Polyclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

Rabbit anti Mouse Fibrinogen Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-511-245421

Buy FGA antibody -

Size:

Related Product Names:

- FGA antibody; FGA; Rabbit anti Mouse Fibrinogen
- Rabbit anti Mouse Fibrinogen; N/A; Fibrinogen alpha chain

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FGA	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_000499.1	Swiss Prot Acc #: P02671
Length (aa): N/A	Mol. Weight (Da): 94973	Chrom Location: N/A

Host Animal: Rabbit

Immunogen: Native mouse fibrinogen

Specificity: Fibrinogen

Specificity: Recognizes mouse fibrinogen. Cross reacts with fibrin.

Type of Product: Polyclonal Antibodies to Platelets and Hemostasis Antigens

Concentration: 17mg/ml (OD280nm, E0.1% = 1.36)

Buffer: 0.05M Sodium phosphate, pH 6.6 containing 0.1M Sodium chloride and 1mM EDTA

Applications Notes : Suitable for use in ELISA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Source/Host: Rabbit

Purity/Purification: Protein A chromatography

Clonality: Polyclonal

Format: Purified, Liquid

Storage: Store at -70 C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FGA ANTIBODY:

ELISA, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

FGA ANTIBODY TARGET DESCRIPTION:

Synonym Names for FGA antibody: FGA; Rabbit anti Mouse Fibrinogen; N/A; Fibrinogen alpha chain

Rabbit anti Mouse Fibrinogen. Rabbit Antibody to Mouse Fibrinogen

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

Subcellular Location: Secreted.

Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.

Ptm: The alpha chain is not glycosylated.

Ptm: Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.

Ptm: About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.

Ptm: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Disease: Defects in FGA are a cause of congenital afibrinogenemia [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations.

Disease: Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.

Disease: Defects in FGA are a cause of amyloidois type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.

Similarity: Contains 1 fibrinogen C-terminal domain.

OMIM: 105200; phenotype. [NCBI / EBI]
134820; gene+phenotype. [NCBI / EBI]
202400; phenotype. [NCBI / EBI]

Products similar to FGA antibody:

IgG

GAGA, IgG

Fibrinopeptide A [1F7], IgG

beta Amyloid [3G5], IgG

TGF alpha [1E8-269], IgG

Fibrinogen [41D9], IgG

Protein

GAGA-POZ domain (1-130aa), Drosophila melanogaster Recombinant, Protein

GAGA-POZ, Protein

PRODUCT INTERACTIONS:

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: FGA antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FGA antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FGA antibody, all related information, articles, resources about FGA antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved