SNRPD1 native protein, Sm/RNP Antigen native protein

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Sm/RNP Antigen native protein

Catalog Number: 11-511-248364

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Related Product Names:

- SNRPD1 native protein; SNRPD1; Sm/RNP Antigen
- Sm/RNP Antigen; Sm-D1; snRNP core protein D1; Sm-D autoantigen; Small nuclear ribonucleoprotein Sm D1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: SNRPD1	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_008869.1	Swiss Prot Acc #: P62314
Length (aa): N/A	Mol. Weight (Da): 13282	Chrom Location: N/A

Specificity: Sm/RNP Antigen

Type of Product: Purified Autoimmune Reagents

Concentration: 0.543mg/ml One unit of activity is the amount of antigen that will generate an absorbance of 1.2 when assayed using standard procedure for enzyme immunoassay. Activity will vary with assay conditions/protocols.

Inactivation: Not applicable.

Preservatives: NaN3

Buffer: 0.01M Tris, 0.53M Sodium chloride

Applications Notes : Recommended for use in standard solid phase immunoassays. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Source/Host: Mixed Bovine/Rab

Purity/Purification: Immobilized human anti-RNP immune globulins. Purification is verified by SDS PAGE. Other antigens (SS-B, SS-A, Scl-70, Jo-1) are not detected with ELISA assays.

Format: Affinity Purified, Liquid

Storage: Store at -70 C. Aliquot to avoid multiple freeze/thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

SNRPD1 NATIVE PROTEIN TARGET DESCRIPTION:

Synonym Names for SNRPD1 native protein: SNRPD1; Sm/RNP Antigen; Sm-D1; snRNP core protein D1; Sm-D autoantigen; Small nuclear ribonucleoprotein Sm D1

Sm/RNP Antigen. Sm/RNP Complex Antigen

Function: May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.

Subunit: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.

Subcellular Location: Nucleus.

Ptm: Methylated by SKB1.

Disease: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.

Similarity: Belongs to the snRNP core protein family.

OMIM: 601063; gene. [NCBI / EBI]

Pathways:
Reactome Event:Gene Expression 74160
Reactome Event:Influenza Infection 168254
Reactome Event:Metabolism of non-coding RNA 194441
Reactome Event:mRNA Processing 75071

Products similar to SNRPD1 native protein:

IgG

SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide 16kDa), IgG

PRODUCT INTERACTIONS:

Sm/RNP Antigen interacts with LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM8), IgG (GenWay Catalog #: 11-511-248364).

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Precautions: SNRPD1 native protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of SNRPD1 native protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SNRPD1 native protein, all related information, articles, resources about SNRPD1 native protein are being stored on our online database. Let us know if you have questions regarding this product.

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