|
|
| Presenilin-2 N-terminal Peptide peptide |
 |
|
|
 |
| Catalog Number: 06-511-248698 |
|
|
|
| Related Product Names:
|
-
PSEN2 peptide; PSEN2; AD4; PS2; PSNL2; STM2; Presenilin-2 N-terminal Peptide
- Presenilin-2 N-terminal Peptide; PS-2; EC 3.4.23.-; STM-2; E5-1; AD3LP; AD5; Presenilin-2 |
|
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
|
|
| Gene Name: PSEN2 |
Gene Name Synonym: AD4; PS2; PSNL2; STM2 |
Gi #:
N/A |
NCBI Acc #:
NP_000438.2 |
Swiss Prot Acc #:
P49810 |
Length (aa): N/A |
Mol. Weight (Da): 50140 |
Chrom Location: N/A |
|
|
 Specificity: Presenilin-2 N-terminal Peptide
Type of Product: Purified Neuroscience Reagents
Concentration: .
Inactivation: Not applicable.
Buffer: Not applicable.
Applications Notes : Specific methodologies have not been tested using this product.
Source/Host: Synthetic
Purity/Purification: 57% pure (Ion Spray Mass Spectrometry)
Format: Purified, Lyophilized.
Reconstitute in sterile distilled water.
Storage: Short-term (up to one month) store at 2-8 C. Long term store at -20 C.
Shipping: Products may be shipped on ice pack or dry ice. |
|
|
|
| PSEN2 PEPTIDE TARGET DESCRIPTION: |
Synonym Names for PSEN2 peptide: PSEN2; AD4; PS2; PSNL2; STM2; Presenilin-2 N-terminal Peptide; PS-2; EC 3.4.23.-; STM-2; E5-1; AD3LP; AD5; Presenilin-2
Presenilin-2 N-Terminal Peptide
Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Subunit: Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL.
Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Tissue Specificity: Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Domain: The PAL motif is required for normal active site conformation (By similarity).
Ptm: Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
Ptm: Phosphorylated on serine residues.
Disease: Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitve abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
Disease: Three causative genes have been identified that when mutated lead to presenile Alzheimer disease: APP (amyloid precursor protein gene), PSEN1 and PSEN2. These three genes account for half of the families with autosomal dominant presenile AD, which represent approximately 10% of the whole AD population. In addition, apolipoprotein E has been identified as a risk-modifying locus.
Similarity: Belongs to the peptidase A22A family [view classification].
OMIM: 600759; gene. [NCBI / EBI]
606889; phenotype. [NCBI / EBI]
Pathways:
KEGG pathway: Alzheimer's disease 05010
KEGG pathway: Neurodegenerative Disorders 01510
KEGG pathway: Notch signaling pathway 04330
Reactome Event:Signaling by Notch 157118
Reactome Event:Signalling by NGF 166520
Products similar to PSEN2 peptide:
IgG
 TFF1 [SPM313], IgG
TFF1, IgG
WFDC1 / PS20, IgG
ALIEN / TRIP15 / COPS2, IgG
Ubiquitin (a.a. 64-76), IgG
Native_Protein
UBIQUITIN, Native_Protein
Ubiquitin Human, Protein
LUNG TRYPTASE ANTIGEN, Protein
Ubiquitin K48R Human, Protein
Ubiquitin Human, Protein
|
|
| PRODUCT INTERACTIONS: |
Presenilin-2 N-terminal Peptide interacts with Amyloid beta A4 protein, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid beta A4 protein, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with AMYLOID PRECURSOR PROTEIN, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with AMYLOID BETA, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Anti Human Beta Amyloid Protein 1-40 (Anti-betaAP1-40), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Anti Human Beta Amyloid Protein 17-42 (Anti-betaAP17-42), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Anti-Human Beta Amyloid Protein Monoclonal Antibody (Anti-Human betaAP), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein [3E9], IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with beta Amyloid [2C8], IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein Frameshift Mutant, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with beta Amyloid [3G5], IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with beta Amyloid [BAM-10], IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Beta Amyloid N-term. (a.a. 1-8), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Beta Amyloid N-term. (a.a. 1-8), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Rabbit anti Beta Amyloid 1-42, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Rabbit anti Beta Amyloid 1-40, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Rabbit A' Amyloid Precursor Pro.(a.a.653-662), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Rabbit A' Amyloid Precursor Pro.(a.a.737-751), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Rabbit anti Amyloid, Beta, N-terminal, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Rabbit anti Rat/Mouse Beta Amyloid (3-16), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Goat A'Amyloid Pre.Pro. Frame (C-term), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein C-term Peptide, Peptide (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Anti-Beta Amyloid, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein (ready-to-use), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with beta Amyloid [DE2B4], IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Beta Amyloid, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with PRC1, IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid beta A4 Variant 40 (A40), IgG (GenWay Catalog #: 06-511-248698).
Presenilin-2 N-terminal Peptide interacts with Amyloid Beta A4 precusor (APP), IgG (GenWay Catalog #: 06-511-248698).
|
|
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: PSEN2 peptide is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of PSEN2 peptide vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PSEN2 peptide, all related information, articles, resources about PSEN2 peptide are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
|
|
|
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
|
|
|
|
|
|
