F9 native protein, Rat Factor IXa native protein

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Peptides \| Secondary Antibodies \| ELISA Kits

Rat Factor IXa native protein

Catalog Number: 11-511-248746

Buy F9 native protein -

Volume:

Related Product Names:

- F9 native protein; F9; Rat Factor IXa
- Rat Factor IXa; EC 3.4.21.22; Christmas factor; Plasma thromboplastin component; PTC; Coagulation factor IX

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: F9	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_000124.1	Swiss Prot Acc #: P00740
Length (aa): N/A	Mol. Weight (Da): 51778	Chrom Location: N/A

Specificity: Factor IXa, Rat

Type of Product: Purified Platelets and Hemostasis Antigens

Inactivation: Not applicable.

Buffer: 20mM HEPES, 0.15M Sodium Chloride, pH 7.4

Applications Notes : Specific methodologies have not been tested using this product.

Concentration: Concentration is lot specific

Source/Host: Rat Plasma

Purity/Purification: Column chromatography

Format: Purified, Liquid

Storage: Store at -80 C.

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

F9 NATIVE PROTEIN TARGET DESCRIPTION:

Synonym Names for F9 native protein: F9; Rat Factor IXa; EC 3.4.21.22; Christmas factor; Plasma thromboplastin component; PTC; Coagulation factor IX

Rat Factor Ixa. . Molecular weight 45 kDa.

Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.

Catalytic Activity: Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

Subunit: Heterodimer of a light chain and a heavy chain; disulfide-linked.

Subcellular Location: Secreted.

Tissue Specificity: Synthesized primarily in the liver and secreted in plasma.

Domain: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.

Ptm: Activated by factor XIa, which excises the activation peptide.

Disease: Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.

Disease: Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.

Pharmaceutical: Available under the names BeneFix (Baxter and American Home Products). Used to treat hemophilia B.

Miscellaneous: In 1952, one of the earliest researchers of the disease, Dr. R.G. Macfarlane used the patient's surname, Christmas, to refer to the disease and also to refer to the clotting factor which he called the 'Christmas Factor' At the time Stephen Christmas was a 5-year-old boy. He died in 1993 at the age of 46 from acquired immunodeficiency syndrome contracted through treatment with blood products.

Similarity: Belongs to the peptidase S1 family [view classification].

Similarity: Contains 2 EGF-like domains.

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain.

Similarity: Contains 1 peptidase S1 domain [view classification].

OMIM: 306900; gene+phenotype. [NCBI / EBI]

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Precautions: F9 native protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of F9 native protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about F9 native protein, all related information, articles, resources about F9 native protein are being stored on our online database. Let us know if you have questions regarding this product.

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