Bcl2l1 antibody, Mouse Anti-Human Bcl-xL Antibody, Mouse Monoclonal Antibody

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Mouse Anti-Human Bcl-xL Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-787-276240

Buy Bcl2l1 antibody -

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Related Product Names:

- Bcl2l1 antibody; Bcl2l1; Bcl2l; Bclx; Mouse Anti-Human Bcl-xL
- Mouse Anti-Human Bcl-xL-FITC; Bcl-2-like 1 protein; Bcl-xL; Apoptosis regulator Bcl-X

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Bcl2l1	Gene Name Synonym: Bcl2l; Bclx
Gi #: 561741	NCBI Acc #: AAA51039.1	Swiss Prot Acc #: Q64373
Length (aa): 233	Mol. Weight (Da): 26132	Chrom Location: N/A

Isotype: Mouse IgG3

Clone: 7B2.5

Immunogen: Recombinant Bcl-xS

Characterization: To insure lot-to-lot consistency, each batch of product is tested by immunoassay to conform to the characteristics of a standard reference reagent.

Specificity: Human Bcl-xL (Mr 29 kDa)
Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems.^1 It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment.^2 Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis^3,4, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis.^5-8 Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2.^9-13 In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2,^5,14 other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.^15,16 Mab 7B2.5 recognizes both human and rodent Bcl-xL.^17

Working Dilution: Flow Cytometry: 3 ug/10^6 cells

Warning: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Human

Format: Fluorescein (FITC) Conjugate

Storage: The purified (UNLB) antibody is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added. Store at 2-8C.
The fluorescein (FITC) conjugate is supplied as 0.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for BCL2L1 ANTIBODY:

IP, IHC, Flow Cytometry (FACS), WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

BCL2L1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Bcl2l1 antibody: Bcl2l1; Bcl2l; Bclx; Mouse Anti-Human Bcl-xL-FITC; Bcl-2-like 1 protein; Bcl-xL; Apoptosis regulator Bcl-X

Function: Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to regulate cell death by binding and blocking the voltage-dependent anion channnel (VDAC), thus preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.

Subunit: Bcl-X(L) forms heterodimers with BAX, BAK and BCL2 (By similarity). Heterodimerization with BAX does not seem to be required for anti-apoptotic activity (By similarity). Also interacts with BBC3 (By similarity). Isoform Bcl-X(L) binds to binds to Siva isoform 1. Interacts with BECN1 and PGAM5 (By similarity). Interacts with BCL2L11.

Subcellular Location: Isoform Bcl-X(L): Mitochondrion membrane. Note=Mitochondrial membranes and perinuclear envelope for Bcl-X(L).

Subcellular Location: Isoform Bcl-X(delta-TM): Cytoplasm.

Tissue Specificity: Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta-TM) expression is enhanced in B- and T-lymphocytes that have been activated.

Developmental Stage: Bcl-X(beta) is expressed in both embryonal and postnatal tissues whereas Bcl-X(L) is predominantly found in postnatal tissues.

Domain: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.

Ptm: Proteolytically cleaved by caspases during apoptosis (By similarity). The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity (By similarity).

Similarity: Belongs to the Bcl-2 family.

Mouse Anti-Human Bcl-xL reacts with human.

Products similar to Bcl2l1 antibody:

IgG

Bcl rambo, IgG

Bcl-X, IgG

BCL-XL (Ab-62), IgG

BAD, IgG

BAD (Ab-136), IgG

Peptide

BAD (Phospho-Ser155) Antibody Blocking Peptide, Peptide

BAD (Phospho-Ser112) Antibody Blocking Peptide, Peptide

BIM(Phospho-Ser69/65) Antibody Blocking Peptide, Peptide

BCL-XL (Phospho-Ser62) Antibody Blocking Peptide, Peptide

BAD Protein Human, Protein

PRODUCT INTERACTIONS:

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for BCL2L1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

Cohen, J.J. 1991. Adv. Immunol. 50:55.
Cohen, J.J., and R.C. Duke. 1992. Annu. Rev. Immunol. 10:2676.
Nunez, G., and M.F. Clarke. 1994. Trends Cell Biol. 4:399.
Cory, S. 1995. Annu. Rev. Immunol. 13:513.
Oltvai., Z.N., C.L. Millman, and S.J. Korsmeyer. 1993. Cell 74:609.
Farrow, S.N., et al. 1995. Nature 374:731.
Chittenden, T., et al. 1995. Nature 374:733.
Kiefer, M.C., et al. 1995. Nature 374:736.
Boise, L.H., M. Gonzalez-Garcia, C.E. Postema, L. Ding, T. Lindstein, L.A. Turka, X. Mao, G. Nunez, and C.B. Thompson 1993. Cell 74:597.
Gottschalk, A.R., L.H. Boise, C.B. Thompson, and J. Quintans. 1994. Proc. Natl. Acad. Sci. USA 91:7350.
Gonzalez-Garcia, M., I. Garcia, L. Ding, S. O'Shea, L.H. Boise, C.B. Thompson, and G. Nunez. 1995. Proc. Natl. Acad. Sci. USA 92:4304
Dole, M.G., R. Jasty, M.J. Cooper, C.B. Thompson, G. Nunez, and V.P. Castle. 1995. Can. Res. 55:2576.
Shimizu, S., et al. 1995. Nature 374:811.
Yin, X.M., Z.N. Oltvai, and S.J. Korsmeyer. 1994. Nature 369:321.
Cheng, E.H.-Y., et al. 1996. Nature 379:554.
Gottschalk, A.R., L.H. Boise, Z.N. Oltvai, M.A. Accavitti, S.J. Korsmeyer, J. Quintans, and C.B. Thompson. 1996. Cell Death and Differentiation 3:113.
Boise, L.H. 1997. Personal communication.
L. Haughan. 1997. Personal communication.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Bcl2l1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Bcl2l1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Bcl2l1 antibody, all related information, articles, resources about Bcl2l1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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